Journal
BIOMEDICAL OPTICS EXPRESS
Volume 1, Issue 1, Pages 260-267Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.1.000260
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Funding
- National Science Foundation [CAREER 08-46660]
- Grainger Foundation
- National Institute of Health [HD007333, HL086070]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0846660] Funding Source: National Science Foundation
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We applied the newly developed Fourier transform light scattering (FTLS) to study dynamic light scattering in single live cells, at a temporal scale of seconds to hours. The nanoscale cell fluctuations were measured with and without the active actin contribution. We found experimentally that the spatio-temporal signals rendered by FTLS reveal interesting cytoskeleton dynamics in glial cells (the predominant cell type in the nervous system). The active contribution of actin cytoskeleton was obtained by modulating its dynamic properties via Cytochalasin-D, a drug that inhibits actin polymerization/depolymerization. (C) 2010 Optical Society of America
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