Article
Oncology
Jiajia Xiong, Wei Zuo, Yu Wu, Xiuhua Wang, Wenqu Li, Qiaodan Wang, Hui Zhou, Mingxing Xie, Xiaojuan Qin
Summary: This study developed and validated a nomogram based on ultrasonography and clinicopathological features of primary tumors to predict the probability of axillary lymph node metastasis in T1-T2 breast cancer patients.
Article
Oncology
Liangyu Gan, Mingming Ma, Yinhua Liu, Qian Liu, Ling Xin, Yuanjia Cheng, Ling Xu, Naishan Qin, Yuan Jiang, Xiaodong Zhang, Xiaoying Wang, Jingming Ye
Summary: A clinical-radiomics model was developed to predict axillary pathologic complete response in breast cancer patients, integrating radiomics features extracted from MRI images and clinicopathologic factors, showing promising predictive performance in screening out patients who may benefit from avoiding lymph node dissection.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Jun Li, Si-Rui Wang, Qiao-Li Li, Tong Zhu, Pei-Shan Zhu, Ming Chen, Xin-Wu Cui
Summary: Early diagnosis of axillary lymph node metastasis is crucial for the prognosis of breast cancer. This study aimed to evaluate the diagnostic performance of various ultrasound methods in detecting axillary lymph node metastasis in breast cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Molly M. Benolken, Sarah McLaughlin, Mara Piltin, Mary Mrdutt, Zhuo Li, James W. Jakub
Summary: This study aimed to determine the frequency of metastatic involvement of an axillary reverse mapping (ARM) lymph node (LN) among patients undergoing axillary lymph node dissection (ALND). Among the 139 patients enrolled, 20% of the patients had a positive ARM LN.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Chemistry, Analytical
Junfei Han, Lu Zhang, Mingyue Cui, Yuanyuan Su, Yao He
Summary: The silicon nanoparticles (SiNPs)-based exosome (SiNPs@EXO) probes can effectively distinguish normal and metastatic sentinel lymph nodes (SLNs), with a high fluorescence signal intensity and long duration marking metastatic SLNs. Compared to clinically used SLN tracers, SiNPs@EXO has better performance and fewer side effects.
ANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Betty Fan, Kelsey Romatoski, Jaime Pardo, Monica Valero, Stephanie Serres, Rene Flores, Ted James
Summary: In this retrospective study using a national cancer database, the researchers found that neoadjuvant chemotherapy does not have an effect on lymph node yield following axillary lymph node dissection in breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Iam Palatnik de Sousa, Marley M. B. R. Vellasco, Eduardo Costa da Silva
Summary: This study presents a novel evolutionary approach for Explainable Artificial Intelligence, combining Local Interpretable Model Agnostic Explanations (LIME) with Multi-Objective Genetic Algorithms. The results show that this methodology can find high quality explanations and has the advantage of automated parameter fine tuning.
Article
Obstetrics & Gynecology
Tanja Ignatov, Johannes Gassner, Mihaela Bozukova, Stylianos Ivros, Jozsef Meszaros, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases in vulvar cancer is low, suggesting a need for further investigation into the impact of contralateral lymphadenectomy on patient survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Oncology
Zhenyu Yang, Xingliang Tan, Yanjun Wang, Yuantao Zou, Dong Chen, Zhiming Wu, Zhuowei Liu, Yonghong Li, Zike Qin, Hui Han, Fangjian Zhou, Kai Yao
Summary: The study evaluated the relationship between deep inguinal lymph node metastasis and pelvic lymph node metastasis in PSCC, finding that deep ILNM is the most accurate factor for predicting PLNM. Patients with deep ILNM should be referred for pelvic lymph node dissection, as it indicates poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Keerthini Muthuswamy, Rebecca Fisher, Stella Mavroveli, Fotis Petrou, Sabrina Khawar, Ashik Amlani, George B. Hanna, Dimitri J. Hadjiminas, Paul T. R. Thiruchelvam, Daniel R. Leff
Summary: A simulator has been designed to safely practice and assess axillary lymph node dissection (ALND), and its face, content, and construct validity has been investigated. The study found that the simulator demonstrated construct validity for ALND assessment and could be a useful tool for skills training and assessments.
Article
Medicine, General & Internal
Bo Chen, Guochun Zhang, Jianguo Lai, Weikai Xiao, Xuerui Li, Cheukfai Li, Hsiaopei Mok, Kai Li, Yulei Wang, Li Cao, Minghan Jia, Chongyang Ren, Lingzhu Wen, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Xiaoqing Chen, Xueying Wu, Henghui Zhang, Min Li, Jing Liu, Charles M. Balch, Ning Liao
Summary: This study revealed significant differences in molecular and immune profiles between single lymph node metastases and multiple lymph node metastases in breast cancer patients. Single lymph node metastases were associated with more aggressive tumor characteristics and more favorable immune characteristics compared to multiple lymph node metastases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lingli Xiao, Jianhua Zhou, Wen Tan, Ying Liu, Haoming Zheng, Guanying Wang, Wei Zheng, Xiaoqing Pei, Ankui Yang, Longzhong Liu
Summary: This study demonstrated that the postvascular phase of CEUS with perfluorobutane had excellent performance in diagnosing suspicious small lateral cervical LNs in patients with PTC. It showed improved diagnostic value compared to traditional ultrasonography alone. Overall, this study highlights the importance of utilizing contrast-enhanced US for better diagnosis of metastatic LNs in PTC.
Article
Oncology
Gilles Houvenaeghel, Alexandre de Nonneville, Nicolas Chopin, Jean-Marc Classe, Chafika Mazouni, Marie-Pierre Chauvet, Fabien Reyal, Christine Tunon de Lara, Eva Jouve, Roman Rouzier, Emile Darai, Pierre Gimbergues, Charles Coutant, Anne Sophie Azuar, Richard Villet, Patrice Crochet, Sandrine Rua, Marie Bannier, Monique Cohen, Jean-Marie Boher
Summary: A study of 1421 breast cancer patients under the age of 75 found that omitting completion axillary lymph node dissection (cALND) in patients with micro-metastases in sentinel nodes was associated with an increased risk of recurrence and death.
Article
Oncology
Jennifer L. Baker, Farnaz Haji, Amy M. Kusske, Cheryce P. Fischer, Anne C. Hoyt, Carlie K. Thompson, Minna K. Lee, Deanna Attai, Maggie L. DiNome
Summary: This study evaluated the feasibility of localizing metastatic lymph nodes with SAVI reflector prior to neoadjuvant chemotherapy for targeted removal at surgery, showing successful localization in some patients and potential advantages in lymph node detection post-surgery.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Rachel E. E. Sargent, Emily Siegel, Fumito Ito, Katherine Kramme, Elizabeth Kraft, Vera Hendrix, Azadeh A. A. Carr, Maria E. E. Nelson, Shelly X. X. Bian, Priya Jayachandran, Stephen F. F. Sener
Summary: This retrospective study aimed to determine the rate of axillary lymph node recurrence in patients with pretreatment biopsy-proven axillary metastases and who were clinically node-negative after neoadjuvant chemotherapy (NAC) using wire-directed (WD) sentinel lymph node dissection (SLND). The results showed that axillary node recurrence was very rare after WD SLND for patients who had pretreatment biopsy-proven node metastases and were ypN0 after NAC. These patients would not likely benefit from additional completion ALND to SLND.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Lavinia P. Middleton, Ron Phipps, Mark Routbort, Victor Prieto, L. Jeffrey Medeiros, Michael Riben, Alejandro Contreras, James Kelley, Keyur Patel, John Bingham, Elizabeth A. Wagar
AMERICAN JOURNAL OF MEDICAL QUALITY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Eric C. Yang, Melody T. Tan, Richard A. Schwarz, Rebecca R. Richards-Kortum, Ann M. Gillenwater, Nadarajah Vigneswaran
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2018)
Article
Multidisciplinary Sciences
Megan Heenan, Jose D. Rojas, Z. Maria Oden, Rebecca Richards-Kortum
Article
Chemistry, Analytical
Mary E. Natoli, Megan M. Chang, Kathryn A. Kundrod, Jackson B. Coole, Gladstone E. Airewele, Venee N. Tubman, Rebecca R. Richards-Kortum
Summary: A rapid and low-cost nucleic acid test for detecting the point mutation in SCD has been developed in this study, showing high sensitivity and specificity with a turnaround time of less than 30 minutes. The test can be performed near the point of care and may be adapted for detecting other disease-causing point mutations in genomic DNA.
ANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Tiffany G. Sheu, Kelly K. Hunt, Lavinia P. Middleton
Summary: Postradiation cutaneous angiosarcoma of the breast is a rare complication associated with adjuvant radiation treatment for breast carcinoma, which has a worse prognosis than the primary cancer. Recent studies have shown that MYC and NOTCH1 receptor expression can serve as markers for secondary radiation-associated angiosarcomas.
Editorial Material
Chemistry, Multidisciplinary
Emilie Newsham, Rebecca Richards-Kortum
ACS CENTRAL SCIENCE
(2021)
Article
Engineering, Biomedical
Catherine E. Majors, Michal E. Pawlowski, Tomasz S. Tkaczyk, Queen Dube, Rebecca Richards-Kortum
Summary: The study demonstrates that LeukoScope can assist in measuring WBC counts in pediatric patients but faces challenges in accurately assessing WBC counts in neonatal patients.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Pediatrics
Jennifer Carns, Sara Liaghati-Mobarhan, Aba Asibon, Alfred Chalira, Norman Lufesi, Elizabeth Molyneux, Maria Z. Oden, Rebecca Richards-Kortum, Kondwani Kawaza
Summary: The study revealed a significant improvement in survival rates for neonates weighing 1.0-1.3 kg after the implementation of CPAP in Malawi government hospitals, with the improvement sustained during the follow-up period. This demonstrates the effectiveness of a nurse-led CPAP program in improving outcomes for this neonatal population.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Engineering, Biomedical
Jesse K. Adams, Dong Yan, Jimin Wu, Vivek Boominathan, Sibo Gao, Alex Rodriguez, Soonyoung Kim, Jennifer Carns, Rebecca Richards-Kortum, Caleb Kemere, Ashok Veeraraghavan, Jacob T. Robinson
Summary: Lensless microscopy with a designed phase mask allows for imaging of biological tissue in vivo, overcoming the limitations of existing techniques. The low-cost and small form factor of this lensless imaging method makes it suitable for clinical use in inaccessible areas of the body.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Huayu Hou, Ruchika Mitbander, Yubo Tang, Ahad Azimuddin, Jennifer Carns, Richard A. Schwarz, Rebecca R. Richards-Kortum
Summary: This article reviews the recent development and application of low-cost optical imaging technologies, emphasizing the integration of artificial intelligence to improve in vivo cancer detection accuracy in low-resource settings. The article also discusses the challenges and future prospects of applying optical imaging technologies in clinical practice.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Georges T. Bouobda, Carmen E. Gonzalez, Ron A. Phipps, Lavinia P. Middleton
ONCOLOGY AND THERAPY
(2020)
Article
Pediatrics
Sonia E. Sosa Saenz, Mary Kate Hardy, Megan Heenan, Z. Maria Oden, Rebecca Richards-Kortum, Queen Dube, Kondwani Kawaza
BMJ PAEDIATRICS OPEN
(2020)
Article
Chemistry, Multidisciplinary
Catherine E. Majors, Michal E. Pawlowski, Daniel C. Burke, Tomasz S. Tkaczyk, Alyssa Rieber, Rebecca Richards-Kortum
Article
Engineering, Biomedical
Sonia Parra, Eduardo Carranza, Jackson Coole, Brady Hunt, Chelsey Smith, Pelham Keahey, Mauricio Maza, Kathleen Schmeler, Rebecca Richards-Kortum
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2020)
Article
Oncology
F. Cardoso, J. M. S. Bartlett, L. Slaets, C. H. M. van Deurzen, E. van Leeuwen-Stok, P. Porter, B. Linderholm, I. Hedenfalk, C. Schroder, J. Martens, J. Bayani, C. van Asperen, M. Murray, C. Hudis, L. Middleton, J. Vermeij, K. Punie, J. Fraser, M. Nowaczyk, I. T. Rubio, S. Aebi, C. Kelly, K. J. Ruddy, E. Winer, C. Nilsson, L. Dal Lago, L. Korde, K. Benstead, O. Bogler, T. Goulioti, A. Peric, S. Litiere, K. C. Aalders, C. Poncet, K. Tryfonidis, S. H. Giordano
ANNALS OF ONCOLOGY
(2018)
