Article
Medicine, General & Internal
Chung-Kuang Ko, Kuan- Huang, Fang-Ying Su, Mei-Lan Ko
Summary: The study found significant differences in peripapillary VD among different stages of glaucoma, suggesting that peripapillary VD measurements can be helpful in differentiating stages of glaucoma severity, even in patients with myopic glaucoma.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Hua Zhong, Qingqing Dong, Qing Cun, Guangyu He, Yijin Tao, Keyao Song, Yunqing Lu, Qin Zhu, Xi Chen, Qin Chen
Summary: This study identified a positive correlation between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in healthy myopic eyes. This correlation was particularly strong in highly myopic eyes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Soo-Ji Jeon, Hae-Young Lopilly Park, Chan-Kee Park
Summary: The study aimed to investigate the association of decreased vessel density in the deep peripapillary region with structural features of the lamina cribrosa. Results showed that eyes with deep vessel density defects in the peripapillary region had thinner lamina cribrosa, and the area with deep vessel density defects had thinner and deeper lamina cribrosa compared to other areas.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Joseph Juliano, Bruce Burkemper, Jae Lee, Andrew Nelson, Vivian LeTran, Zhongdi Chu, Gabriella Zhou, Xuejuan Jiang, Ruikang K. Wang, Rohit Varma, Grace M. Richter
Summary: The study aimed to explore the relationship of intraocular pressure (IOP) with peripapillary vessel density (pVD) in glaucoma versus non-glaucomatous eyes, focusing on how axial length (AL) affects this relationship. Results showed that higher IOP was associated with lower pVD in glaucomatous eyes with longer AL, indicating potential retinal autoregulation issues in these individuals.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Yufei Wu, Qiaoli Yang, Liujun Ding, Yunhai Tu, Xiaoyu Deng, Yan Yang, Meixiao Shen, Qinkang Lu, Fan Lu, Qi Chen
Summary: The study revealed that patients with suspected dysthyroid optic neuropathy (DON) in thyroid-associated ophthalmopathy (TAO) had significantly lower optic nerve head vessel density and peripapillary capillary vessel density, especially in the temporal and upper regions, as detected by optical coherence tomography angiography (OCTA) technology.
Article
Ophthalmology
Hae-Young Lopilly Park, Kyung Euy Hong, Da Young Shin, Younhea Jung, Eun Kyoung Kim, Chan Kee Park
Summary: Microvascular changes in glaucoma patients were evaluated using OCT-A post glaucoma surgery, showing significant increases in deep vessel density in the intradisc area and decreases in the area of the foveal avascular zone in the deep vascular layer. Increase in deep vessel density in the laminar region of the optic nerve head was beneficial to visual field progression in glaucoma patients after surgery.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Thanh-Tin P. Nguyen, Shuibin Ni, Guangru Liang, Shanjida Khan, Xiang Wei, Alison Skalet, Susan Ostmo, Michael F. Chiang, Yali Jia, David Huang, Yifan Jian, J. Peter Campbell
Summary: OCT has changed the standard of care for macular diseases in adults, but commercially available systems have a narrow FOV limiting their application to peripheral pathologies; OCT-based evaluation can improve diagnosis of all types of retinal detachment.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Philipp Matten, Julius Scherer, Thomas Schlegl, Jonas Nienhaus, Heiko Stino, Michael Niederleithner, Ursula M. Schmidt-Erfurth, Rainer A. Leitgeb, Wolfgang Drexler, Andreas Pollreisz, Tilman Schmoll
Summary: Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults with diabetes mellitus, and optical coherence tomography angiography (OCTA) has shown potential as a tool for early diagnosis. We propose a multiple instance learning-based network, MIL-ResNet, capable of detecting biomarkers in OCTA images with high accuracy without pixel-level annotations. Our method outperforms previous state-of-the-art networks and is robust against adversarial attacks, making it a powerful diagnostic decision support tool for clinical ophthalmic screening.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Jooyoung Yoon, Kyung Rim Sung, Joong Won Shin
Summary: The study aimed to determine factors associated with visual field deterioration after trabeculectomy, focusing on peripapillary and macular vessel density changes assessed by OCT-A. Results suggest that changes in peripapillary vessel density may play a role in predicting visual function post-trabeculectomy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Si-Eun Oh, Hee-Jong Shin, Chan-Kee Park, Hae-Young Lopilly Park
Summary: Superficial and deep macular vessel density is decreased in glaucoma patients. We evaluated the vascular changes in the axon and soma/dendrite of retinal ganglion cells using adjusted macular segmentation. A lower GC/IPL VD ratio was associated with lower RNFL VD and systemic hypertension. Patients with reduced GC/IPL VD ratio were more likely to have visual field defects and paracentral scotoma, as well as receive treatment for systemic hypertension.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Paolo Milani, Lara Enrica Urbini, Ennio Bulone, Ugo Nava, Deborah Visintin, Giorgia Cremonesi, Lorenza Scotti, Fulvio Bergamini
Summary: Using OCTA, the perfusion area of the choriocapillaris in the macular area was found to be similar in eyes with primary open-angle glaucoma, eyes with ocular hypertension, and healthy eyes. Diurnal changes in the investigated parameters were not statistically significant.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Mert Simsek, Onur Inam, Emine Sen, Ufuk Elgin
Summary: This study found that patients with XFS had decreased choroidal vascularity in the macular and peripapillary regions, while unaffected fellow eyes may show vascular changes in the peripapillary choroid.
Article
Biochemistry & Molecular Biology
John Moir, Shivam Amin, Saira Khanna, Rahul Komati, Lincoln T. Shaw, David Dao, Seenu M. Hariprasad, Dimitra Skondra
Summary: This case series highlights the use of optical coherence tomography angiography (OCTA) as a valuable imaging modality to distinguish atypical MacTel from other macular conditions. OCTA revealed telangiectatic vessels in all 15 eyes and identified previously undiagnosed subretinal neovascularization in some eyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Yan Yan, Xiao Zhou, Zhongdi Chu, Laurel Stell, Mohammad Ali Shariati, Ruikang K. Wang, Yaping Joyce Liao
Summary: ODD has a significant impact on the peripapillary vasculature and nerve fibers, with decreased VAD and VCI in multiple quadrants. While OCT and OCTA measurements were significantly impacted, the effect on visual field MD was relatively mild, suggesting a dissociation between structural changes and corresponding visual function in ODD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Hoang Mai Le, Eric H. Souied, Safa Halouani, Enrico Borrelli, Thibaut Chapron, Giuseppe Querques, Alexandra Miere
Summary: Quantitative analysis of choriocapillaris perfusion in eyes with angioid streaks using SS-OCTA showed reduced flow compared to control eyes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
Tristan T. Hormel, Thomas S. Hwang, Steven T. Bailey, David J. Wilson, David Huang, Yali Jia
Summary: Optical coherence tomographic angiography (OCTA) is a non-invasive imaging technique that provides three-dimensional vascular images, while artificial intelligence (AI) based image analysis can accurately quantify vascular features and pathology in various disease contexts of the eye. This combination shows promise in accurate diagnosis in different disease and eye regions.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Biochemical Research Methods
Xiang Wei, Tristan T. Hormel, Yali Jia
Summary: Optical coherence tomography angiography (OCTA) is a method used for vascular imaging in experimental and clinical applications. It provides high-sensitivity, high-resolution angiograms by measuring motion contrast in the reflectance signal. OCTA utilizes changes in the reflectance signal to generate angiographic images, with the choice of signal processing method affecting flow signal sensitivity and dynamic range.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biochemical Research Methods
Shuibin Ni, Xiang Wei, Ringo Ng, Susan Ostmo, Michael F. Chiang, David Huang, Yali Jia, J. Peter Campbell, Yifan Jian
Summary: Optical coherence tomography (OCT) and OCT angiography (OCTA) allow noninvasive imaging of eye structures and blood vessels, playing a critical role in diagnosing and monitoring vascular eye diseases. Handheld OCT/OCTA systems offer flexibility and portability in eye imaging, although high image acquisition speed and stability are essential for obtaining quality images.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Ophthalmology
Qi Sheng You, Ou Tan, Shaohua Pi, Liang Liu, Ping Wei, Aiyin Chen, Eliesa Ing, Yali Jia, David Huang
Summary: This study assessed the effects of algorithms and covariates in glaucoma diagnosis with OCTA. The results showed that different algorithms for measuring vascular density were highly correlated but had poor agreement, and age and signal strength were significant covariates. There were no significant differences in diagnostic accuracy between algorithms, between structural and perfusion parameters, and between different measurement regions for glaucoma detection.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Honglian Xiong, Qi Sheng You, Yukun Guo, Jie Wang, Bingjie Wang, Liqin Gao, Christina J. Flaxel, Steven T. Bailey, Thomas S. Hwang, Yali Jia
Summary: A deep-learning-based macular extrafoveal avascular area (EAA) measured on a 6x6 mm OCT angiogram is less dependent on signal strength and shadow artefacts, and provides better diagnostic accuracy for diabetic retinopathy (DR) severity than the commercial software measured extrafoveal vessel density (EVD).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemical Research Methods
Yukun Guo, Tristan T. Hormel, Shaohua Pi, Xiang Wei, Min Gao, John C. Morrison, Yali Jia
Summary: This study presents a deep-learning-based method for segmenting retinal capillary plexuses directly from volumetric OCTA data, showing feasibility and potential for simplifying OCTA data processing for retinal vasculature segmentation. The proposed technique includes a custom projection module to connect retinal layer segmentation and vasculature segmentation modules, establishing an end-to-end method without human intervention.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Ophthalmology
Kotaro Tsuboi, Qi Sheng You, Yukun Guo, Jie Wang, Christina J. Flaxel, Steven T. Bailey, David Huang, Yali Jia, Thomas S. Hwang
Summary: In diabetic macular edema, the correlation between visual acuity and central subfield thickness is weak. However, the fluid volume in the inner nuclear layer may have a stronger correlation with visual acuity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemical Research Methods
Shaohua Pi, Tristan T. Hormel, Bing Jie Wang, Steven T. Bailey, Thomas S. Hwang, David Huang, John C. Morrison, Yali Jia
Summary: Optical coherence tomography (OCT) is widely used in ophthalmic practice for visualizing retinal structure and vasculature. This study proposes a novel framework that can detect retinal pathologies in three dimensions using OCT. The framework utilizes deviations in reflectance, angiography, and simulated perfusion to detect abnormalities, eliminating the need for extensive retinal layer segmentation. The study also introduces a composite pathology index that correlates with disease severity. The fully automated 3D framework has the potential to benefit ophthalmology research and clinical care.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Optics
Xiang Wei, Tristan T. Hormel, Shaohua Pi, Bingjie Wang, John C. Morrison, Yali Jia
Summary: In this study, a sensorless adaptive optics swept-source optical coherence tomographic angiography (sAO-SS-OCTA) imaging system for mice was presented, and high-resolution images with aberrations corrected and contrast enhanced were successfully acquired.
Article
Biochemical Research Methods
Jie Wang, Tristan T. Hormel, Steven T. Bailey, Thomas S. Hwang, David Huang, Yali Jia
Summary: In this study, a novel signal attenuation-compensated projection-resolved optical coherence tomographic angiography (sacPR-OCTA) algorithm is proposed to remove projection artifacts and compensate for shadows beneath large vessels. The sacPR-OCTA algorithm improves vascular continuity, reduces the similarity of vascular patterns in different plexuses, and removes more residual artifacts compared to existing methods. Additionally, it better preserves flow signal in choroidal neovascular lesions and shadow-affected areas. The sacPR-OCTA algorithm provides a general solution for removing projection artifacts agnostic to the platform by processing data along normalized A-lines.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Pengxiao Zang, Tristan T. Hormel, Thomas S. Hwang, Steven T. Bailey, David Huang, Yali Jia
Summary: This study proposes an automated diagnostic framework based on structural OCT and OCTA data volumes, which can greatly support the clinical application of these technologies. The deep learning framework trained in this study can provide reliable, sensitive, interpretable, and fully automated diagnosis of eye diseases by classifying structural OCT and OCTA scans.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Computer Science, Interdisciplinary Applications
Shuibin Ni, Thanh-Tin P. Nguyen, Ringo Ng, Mani Woodward, Susan Ostmo, Yali Jia, Michael F. Chiang, David Huang, Alison H. Skalet, J. Peter Campbell, Yifan Jian
Summary: A new concept of panoramic retinal optical coherence tomography (OCT) imaging system with a wide field of view is introduced. This system uses a contact imaging approach to achieve faster and more efficient retinal imaging, along with measurement of axial eye length. The handheld panretinal OCT imaging system allows earlier recognition of peripheral retinal disease and offers significant value in both clinical ophthalmology and basic vision science.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Optics
Siyu Chen, Shuibin Ni, Alfonso Jimenez-Villar, Yifan Jian, Yali Jia, David Huang
Summary: This study introduces a new method called optical coherence tomography (OCT) split-spectrum amplitude decorrelation optoretinography (SSADOR) for measuring photoreceptor response to light stimuli. SSADOR utilizes spectrally multiplexed narrowband OCT to enhance sensitivity to microscopic changes. It enables a large field of view in conventional OCT instrument design, making it suitable for clinical applications. SSADOR could serve as a fast, objective, and quantifiable functional biomarker for evaluating photoreceptor damage in the macula.
Review
Biochemical Research Methods
Tristan t. Hormel, Yali Jia
Summary: Optical coherence tomography angiography (OCTA) is a high-resolution and depth-resolved imaging technique used for non-invasive imaging and quantitative analysis of retinal and choroidal vasculature, providing important biomarkers for clinical practice and therapeutic research.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Guangru b. Liang, Tristan t. Hormel, Xiang Wei, Yukun Guo, Jie Wang, Thomas Hwang, Yali Jia
Summary: In this study, a prototype of optical coherence tomographic angiography (OCTA) using a high-speed swept-source laser was developed. The prototype can generate wide-field and high-resolution images of the retina and choroid in a single acquisition, allowing for detection and localization of diabetic retinopathy. It can also visualize choroidal flow and identify biomarkers in diabetic retinopathy.
BIOMEDICAL OPTICS EXPRESS
(2023)