Stress, acute phase proteins and immune modulation in calves

Acute phase and inflammatory responses are triggered by a variety of intrinsic and extrinsic stressors that come at a cost through suppressing the normal function of tissues and organs of domestic animals. Recently, with growing attention placed on global warming and animal welfare, there has been an increased interest in improving our understanding of the relationships between different classes of stress, the expression of acute phase proteins (APPs), the stress-related endocrine system and immunomodulation. Immune function is compromised by all forms of stress including poor nutrition, weaning, extreme thermal conditions, injury and infection in calves. Proinflammatory cytokines, APPs and hormones of the hypothalamic-pituitary adrenal axis as well as the composition of immune cells can all be characterised in culture supernatants and peripheral blood. APPs have been used as biomarkers for the stress status of ruminants both experimentally and in field studies. Therefore detailed studies of the mechanisms of action of these APPs and their interactions in ameliorating different stress responses are warranted. The focus of this review is on the aetiology of the responses in calves under severe stress and its impact on growth and immune status. Possible strategies to alleviate this condition including the role of specific feed additives are presented.