Article
Allergy
Magnus Lindqvist, Katja Biering Leth-Moller, Allan Linneberg, Inger Kull, Anna Bergstrom, Antonios Georgellis, Magnus P. Borres, Agneta Ekebom, Marianne van Hage, Erik Melen, Marit Westman
Summary: Patients with pollen-induced allergic rhinitis face a high risk of persistent disease for at least 20 years, with childhood to adolescence being the most critical period for disease progression. The study findings underscore the close relationship between sensitization, allergic rhinitis, and asthma.
Article
Allergy
Tomoko Tajiri, Motohiko Suzuki, Takeo Kutsuna, Hirono Nishiyama, Keima Ito, Norihisa Takeda, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Satoshi Fukuda, Takehiro Umemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Kosho Yoshikawa, Akio Niimi
Summary: This study aimed to assess whether pretreatment specific IgE response could predict responsiveness to omalizumab in patients with severe allergic asthma sensitized to perennial allergens. The results showed that sensitization to pollen was independently associated with the effectiveness of omalizumab.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Food Science & Technology
Chia-Jung Li, Ling-Sai Chang, Mindy Ming-Huey Guo, Liang-Jen Wang, Ho-Chang Kuo
Summary: This study aimed to investigate the role of vitamin D in children with coexisting allergic diseases, particularly in terms of sex differences, and to explore the behavioral profiles of these patients. The study found that males with two or more allergic diseases had significantly lower levels of vitamin D, while the levels of IgE were negatively correlated with vitamin D in females. Additionally, serum IgE was significantly correlated with children's adaptive skills, and different sexes were associated with different aspects of adaptive skills. Therefore, vitamin D has a protective role in the development of one allergic disease against the coexistence of allergic diseases in males, and the study extends the evidence for sex differences in immunity.
FOOD SCIENCE & NUTRITION
(2023)
Article
Medicine, General & Internal
Yi-Han Li, Chen-Jie Yu, Xiao-Yun Qian, Pan-Pan Song, Xia Gao
Summary: This study evaluated the correlation between fractional exhaled nitric oxide (FeNO) and nasal nitric oxide (nNO) in patients with allergic rhinitis (AR) and bronchial asthma (BA). The results showed that FeNO and nNO levels were positively correlated with the severity of AR in patients with BA, with nNO levels being used as an inflammatory marker of AR in BA patients. FeNO can also serve as an inflammatory marker of AR in patients with BA as a warning indicator of asthma.
Article
Multidisciplinary Sciences
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Buegel, Orestes A. Carpaij, Erick Forno, Andreanne Morin, Anders U. Eliasen, Yale Jiang, Maarten Van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bonnelykke, Juan C. Celedon, Gerard H. Koppelman, Cheng-Jian Xu
Summary: The study demonstrates that nasal DNA methylation is the most accurate predictor for diagnosing childhood allergic diseases, identifying multimorbidity and IgE sensitization, with findings replicated in children of different ages and ethnicities.
NATURE COMMUNICATIONS
(2022)
Article
Allergy
Jo A. Douglass, Caroline Lodge, Samantha Chan, Alice Doherty, Ju Ann Tan, Celina Jin, Alastair Stewart, Anne M. Southcott, Andrew Gillman, Joy Lee, Danny Csutoros, Liam Hannan, Laurence Ruane, Sara Barnes, Lou Irving, Nur-Shirin Harun, Phillipe Lachapelle, Kymble Spriggs, Michael Sutherland, Katharine See, Christine F. McDonald, Matthew Conron, Naghmeh Radhakrishna, Christopher Worsnop, Fay H. Johnston, Janet M. Davies, Vanessa Bryant, Linda Iles, David Ranson, Paresa Spanos, Don Vicendese, Adrian Lowe, Edward J. Newbigin, Philip Bardin, Shyamali Dharmage
Summary: This study found that low FEV1 value, high Asthma Control Questionnaire score, and elevated levels of RGP-sp IgE concentration, eosinophil counts, and fractional exhaled nitric oxide were associated with the risk of thunderstorm asthma among individuals with seasonal allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Michael S. Benninger, Claudia Cabrera, Eulalia M. Amador, Kevin Grafmiller, Raj Sindwani
Summary: This study explores the relationship between specific allergen sensitization and asthma severity. It found that positive tests for cat dander, dog dander, certain fungi, and house dust were associated with more severe asthma.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Review
Pharmacology & Pharmacy
Yasuhiro Gon, Shuichiro Maruoka, Kenji Mizumura
Summary: Omalizumab is a therapeutic agent for severe bronchial asthma. It improves symptoms, reduces exacerbation risk, and enhances quality of life. However, it is associated with high treatment costs and lacks clear methods to identify responders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zhan Zhao, Yuqin Deng, Lei Xiang, Jin Chen, Jing Wan, Jinli Sun, Yonggang Kong, Qingquan Hua
Summary: This study aimed to evaluate the clinical efficacy of omalizumab in patients with allergic rhinitis by analyzing the ratio of total IgE level at week 16 to baseline. Retrospective analysis of 62 patients showed that 48 patients demonstrated significant improvement after 16 weeks of treatment, while 14 patients did not show significant improvements. The ratio of total IgE levels at week 16 to baseline was higher in responders compared to non-responders. In conclusion, the ratio of total IgE level at week 16 to baseline correlated with the clinical response to omalizumab in moderate to severe allergic rhinitis patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Hee-Kyung Joh, Hyuktae Kwon, Ki Young Son, Jae Moon Yun, Su Hwan Cho, Kyungdo Han, Jin-Ho Park, Belong Cho
Summary: This study examines the association between the allergic triad (asthma, allergic rhinitis, atopic dermatitis) and the risk of dementia. The results indicate that allergic diseases are positively associated with dementia risk, and the severity of allergic diseases has a dose-effect relationship with dementia risk.
ANNALS OF NEUROLOGY
(2023)
Review
Allergy
Birgit Pfaller, Sarah Bendien, Agnes Ditisheim, Thomas Eiwegger
Summary: Managing allergic diseases during pregnancy presents challenges and potential risks for mother and child, especially with limited safety data on anti-allergic drugs during pregnancy.
Article
Health Care Sciences & Services
Serafeim Chrysovalantis Kotoulas, Ioanna Tsiouprou, Eva Fouka, Athanasia Pataka, Despoina Papakosta, Konstantinos Porpodis
Summary: This review summarizes the knowledge of almost two decades of use of omalizumab in patients with severe allergic asthma. Evidence suggests that omalizumab improves asthma control and reduces the incidence and frequency of exacerbations. It is also effective in reducing corticosteroid use and healthcare utilization.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Allergy
David C. Wraith, Mamidipudi T. Krishna
Summary: Allergen-specific immunotherapy is the only way to change the natural immune response of allergic diseases, and using peptides based on CD4(+) T cell epitopes instead of whole allergens may overcome the challenges of current treatment methods.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Nanoscience & Nanotechnology
Meng-Ru Ding, Qi-Lin Liang, Huan-Ge Xu, Xiang-Dan Li, Kuo Zhang, Zi-Jin Wei, Yong-Hong Gao, Qing-Shi Zhang, Rui Huang, Huai Yang, Lei Wang, Hao Wang
Summary: This study introduces a Smart PeptIde defeNse (SPIN) web technique that can trap IgE to prevent allergic rhinitis (AR) and other allergic reactions. The technique shows promising results in reducing the symptoms of rhinitis and inflammatory factors, surpassing a first-line clinical drug in efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Maria Maddalena Sirufo, Francesca De Pietro, Lia Ginaldi, Massimo De Martinis
Summary: Gender differences are increasingly recognized in medicine, but specific gender-targeted studies are lacking. Considering gender pharmacology is crucial for optimizing drug therapies. Further development of gender research can identify potential risks and benefits between genders and enable personalized medicine.
Editorial Material
Allergy
Ga-Young Ban, Young -Min Ye
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Allergy
Bo Youn Choi, Eun-Mi Yang, Hae-Won Jung, Min-Kyoung Shin, Junghyun Jo, Hyun-Young Cha, Hae-Sim Park, Ho-Chul Kang, Young-Min Ye
Summary: The study found a new autoantibody called anti-HSP10 IgG in patients with CSU, which showed a significant correlation with the severity of the disease. CSU patients had lower levels of HSP10 and higher levels of miR-101-5p compared to normal controls. MiR-101-5p promoted mast cell degranulation through upregulation of IL-4 and PAF, while HSP10 provided protection against it.
Article
Medicine, General & Internal
Young-Min Ye
Summary: Chronic urticaria is a debilitating condition that significantly affects quality of life, and current treatment options, including antihistamines and omalizumab, are not effective for all patients. Ongoing research is investigating the therapeutic potential of other biological products targeting different aspects of the disease.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Ju-Yang Jung, Chang -Hee Suh, Young-Min Ye, Hyoun-Ah Kim
Summary: This study compared the occurrence of adverse events and disease flares after COVID-19 and influenza vaccination in patients with autoimmune rheumatic diseases (ARDs). The results showed that the rates of adverse events and disease flares were significantly higher after COVID-19 vaccination than after influenza vaccination. Previous allergic reactions to other vaccines were the only factor associated with the occurrence of adverse events. There was no difference in the post-vaccine response between mixed and matched vaccines.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Allergy
Mi-Ae Kim, Jeong-Hee Choi, Yoo-Seob Shin, Hae-Sim Park, Young-Min Ye
Summary: The prevalence of chronic urticaria (CU) is increasing globally and poses a significant burden on patients. This study compared the efficacy and safety of second-line treatments for CU refractory to standard doses of nonsedating H1-antihistamines (nsAHs). The results showed that increasing the dose of nsAHs four-fold and using a combination of multiple nsAHs were effective in controlling CU, but increasing the dose of nsAHs four-fold was more effective in achieving complete control of CU.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Letter
Allergy
Hyeukjun Sohn, Joo-Hee Kim, Jae-Hyuk Jang, Seung-Hyun Kim, Hae-Sim Park
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Allergy
Thi Bich Tra Cao, Quang Luu Quoc, Eun-Mi Yang, Ji-Young Moon, Yoo Seob Shin, Min Sook Ryu, Youngwoo Choi, Hae-Sim Park
Summary: This study found that tissue inhibitor of metalloproteinase-1 (TIMP-1) plays an important role in the pathogenesis of severe asthma (SA) by enhancing eosinophilic airway inflammation. Serum levels of TIMP-1 were significantly higher in asthmatics, especially in the SA group. There was a negative correlation between serum TIMP-1 levels and FEV1% values in SA patients. In vitro and in vivo experiments further confirmed that TIMP-1 can directly activate eosinophils and macrophages, induce the release of eosinophil extracellular traps, and promote macrophages to polarize towards the M2 subset, all of which can be suppressed by anti-TIMP-1 antibody.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Review
Allergy
Youngwoo Choi, Hae-Sim Park, Yoon-Keun Kim
Summary: Extracellular vesicles (EVs) are released from various living cells and play important roles in intracellular communication. They contain proteins, lipids, and nucleic acids and can affect immune responses, contributing to health and disease. Bacterial EVs, a new area of research, have potential as immunomodulators for targeting asthma and atopic dermatitis.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Soyoon Sim, Dong-Hyun Lee, Kwang-sun Kim, Hyeon Ju Park, Yoon-Keun Kim, Youngwoo Choi, Hae-Sim Park
Summary: Bacterial extracellular vesicles (EVs) from Micrococcus luteus have been found to regulate airway inflammation and improve lung function in asthma patients. These EVs specifically increase the levels of IgG4 and miRNA expression, which inhibit neutrophilic inflammation and improve respiratory symptoms. Therefore, MlEVs could be a potential novel therapeutic agent for managing neutrophilic asthma.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Review
Allergy
Jae-Hyuk Jang, Joo-Hee Kim, Hae-Sim Park
Summary: This review provides an overview of the epidemiological data of immunoglobulin G subclass deficiency (IGGSCD) in adults, as well as detailed information on the investigation, treatment, and management strategies. IGGSCD is commonly found in patients with chronic respiratory diseases and can lead to severe respiratory complications.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Allergy
Sangroc Kang, Jae-Hyuk Jang, Hyun-Seob Jeon, Ga-Young Ban, Hae-Sim Park
Summary: CysLTs play a significant role in type 2 inflammation in the airways of asthmatic patients, leading to the development of AERD, CRS, and asthma severity. Stratification of clinical phenotypes based on uLTE4 levels could help optimize anti-inflammatory therapy for improved asthma control.
ALLERGY ASTHMA & RESPIRATORY DISEASE
(2023)
Article
Allergy
Eun-Kyung Kwon, Tae-Wook Kang, Taeyun Oh, Oak-Sung Choo, Young-Min Ye, Hae-Sim Park, Ga-Young Ban
Summary: This study aimed to determine the novel pathogenic features of aspirin-exacerbated respiratory disease (AERD) by performing integrative analysis of transcriptomic and epigenomic profiling with network analysis. The results identified differentially expressed genes and differentially methylated probes between patients with AERD and those with aspirin tolerant asthma (ATA), and revealed the involvement of genes related to vesicle transport and sphingolipid dysregulation in AERD. Furthermore, the study generated signaling pathways related to T helper cell differentiation/activation and Fc epsilon receptor I, and found significant up-regulation of specific genes in AERD compared to ATA. This study provides insights into the distinct pathogenic features of AERD.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)