Article
Medicine, General & Internal
Ikhwan Rinaldi, Mondastri Korib Sudaryo, Nurhayati Adnan Prihartono
Summary: This study found that the prevalence of DIC in septic patients was 20.2%. Low albumin, respiratory infection, and antibiotic treatment >= 1 h were identified as risk factors for the development of DIC in septic patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Hematology
Takeshi Wada, Satoshi Gando
Summary: The two phenotypes of disseminated intravascular coagulation (DIC) are thrombotic and fibrinolytic, characterized by thrombosis and hemorrhage respectively. Thrombotic DIC is caused by coagulation activation, insufficient anticoagulation, and inhibition of fibrinolysis, leading to microvascular fibrin thrombosis and organ dysfunction. Fibrinolytic DIC is characterized by extensive thrombin generation and systemic pathologic hyperfibrinolysis, resulting in severe bleeding.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Yan Zhang, Congqing Wu, Lan Li, Ankit Pandeya, Guoying Zhang, Jian Cui, Daniel Kirchhofer, Jeremy P. Wood, Susan S. Smyth, Yinan Wei, Zhenyu Li
Summary: Histones can trigger coagulation activation, and lytic cell death is a novel mechanism of histone-induced coagulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Norihisa Yasuda, Koji Goto, Yoshihide Kuribayashi, Yoshifumi Ohchi, Takaaki Kitano
Summary: This study retrospectively investigated the incidence, outcome, and risk factors of cardiovascular surgery-associated DIC. The study found that female sex, preoperative DIC score, and anesthesia time were identified as risk factors for DIC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Benjamin Giszas, Michael Fritzenwanger, Marc-Oliver Grimm, Andreas Stallmach, Philipp A. Reuken
Summary: This case report describes a elderly man with recurrent severe bleeding events due to disseminated intravascular coagulation (DIC) caused by prostate cancer. Treatment with a single injection of the GnRH receptor antagonist degarelix led to rapid stabilization of coagulation and a decrease in prostate-specific antigen (PSA). However, one year after initiating androgen-deprivation therapy, there were recurrent transfusion-requiring bleeding events and an increase in PSA.
Review
Medicine, General & Internal
Junjun Wu, Huaming Li, Yufang Wang, Rong Xu
Summary: This case report highlights the importance of early diagnosis of disseminated intravascular coagulation (DIC) and reviews the clinical indicators of E coli infection and DIC. The patient, a 48-year-old man with symptoms of diarrhea, nausea, vomiting, fever, and loss of consciousness, was diagnosed with acute gastroenteritis complicated by DIC. Timely assessment of platelet count, procalcitonin level, coagulation function, and rational use of antibiotics can improve the prognosis of patients.
Article
Immunology
Guillain Mikaty, Christian E. Demeure, Sofia Filali, Javier Pizarro-Cerda, Pierre Goossens, Elisabeth Carniel
Summary: This study aimed to determine whether DIC occurs at the late stages of plague and anthrax. The results showed that animals infected with anthrax exhibited typical DIC characteristics, while those infected with plague did not. Therefore, understanding the mechanisms behind these hemorrhages is crucial.
MICROBES AND INFECTION
(2023)
Article
Medicine, General & Internal
Malgorzata Skalska-Swistek, Hubert Huras, Andrzej Piotr Jaworowski, Rafal Swistek, Magdalena Kolak
Summary: Coagulopathies are important obstetric complications, and DIC syndrome is a severe and complex clotting disorder. Close monitoring of laboratory parameters of the coagulation system, fetal health, and timely delivery and initiation of intensive therapy are necessary.
Article
Medicine, General & Internal
Hideo Wada, Akitaka Yamamoto, Masaki Tomida, Yuhuko Ichikawa, Minoru Ezaki, Jun Masuda, Masamichi Yoshida, Shunsuke Fukui, Isao Moritani, Hidekazu Inoue, Katsuya Shiraki, Kei Suzuki, Hiroshi Imai, Motomu Shimaoka, Hideto Shimpo
Summary: This study proposed a quick DIC score system for the diagnosis of DIC and pre-DIC. By examining platelet counts, prothrombin time-international normalized ratio (PT-INR), and D-dimer levels, appropriate cut-off values were determined, and a simple scoring system was proposed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Food Science & Technology
Akihiko Yamamoto, Takashi Ito, Toru Hifumi
Summary: The study investigated the application of recombinant thrombomodulin alpha as a therapeutic agent for Yamakagashi bites and confirmed its therapeutic effect in both in vitro and in vivo experiments.
Review
Hematology
Kasper Adelborg, Julie B. Larsen, Anne-Mette Hvas
Summary: Disseminated intravascular coagulation (DIC) is a systemic activation of the coagulation system, leading to microvascular thrombosis and hemorrhage. Underlying conditions like infection, cancer, or obstetrical complications initiate and propagate the DIC process. Timely and accurate diagnosis and treatment of DIC and its underlying causes are essential for prognosis.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Francesco Monaco, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri, Tiziana Genovese
Summary: The study found that um-PEA can reduce changes in coagulation markers and proinflammatory cytokine release caused by LPS, as well as prevent the formation of fibrin deposition and lung damage. Furthermore, um-PEA can also reduce the number of mast cells and the release of serine proteases, which are necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be a potential therapeutic approach in managing DIC and associated clinical implications of coagulopathy and lung dysfunction, such as COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Akitaka Yamamoto, Hideo Wada, Masaki Tomida, Yuhuko Ichikawa, Minoru Ezaki, Katsuya Shiraki, Motomu Shimaoka, Toshiaki Iba, Katsue Suzuki-Inoue, Masahide Kawamura, Hideto Shimpo
Summary: The scoring systems for DIC criteria are complicated and require multiple cutoff values, making them less practical. Therefore, a simpler and quicker diagnostic method for DIC is needed. sCLEC-2 has potential as a biomarker for platelet activation, and the sCLEC-2xD-dimer/PLT formula shows high diagnostic utility for both pre-DIC and DIC.
Article
Medicine, General & Internal
Akitaka Yamamoto, Hideo Wada, Yuhuko Ichkawa, Motoko Tanaka, Haruhiko Tashiro, Katsuya Shiraki, Hideto Shimpo, Yoshiki Yamashita, Takeshi Mastumoto, Motomu Shimaoka, Toshiaki Iba, Katsue Suzuki-Inoue
Summary: The plasma levels of sCLEC-2 and D-dimer are significantly higher in patients with DIC and Pre-DIC, serving as markers for these conditions and as prognostic indicators in critically ill patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Elizabeth Geyer-Roberts, Tanisha Akhand, Alexandra Blanco, Robin Jose, Nayeem Chowdhury, Michael Ea, Eric Gutierrez, Jacqueline Balbuena, Sophia Anagnostis, Claudia Henderson, Alexis Fazio, Alexander Burpee, Robin J. Jacobs
Summary: DIC is a serious syndrome characterized by blood coagulation, with vulnerable populations such as pregnant women, pediatric patients, and the elderly at higher risk. Early diagnosis and treatment of underlying conditions are crucial in managing DIC effectively.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
