Article
Dentistry, Oral Surgery & Medicine
Piero Papi, Diego Penna, Bianca Di Murro, Giorgio Pompa
Summary: The study reported a significant increase in mucosal thickness one year after treatment with acellular dermal matrix, with a mean gain of 1.25 mm. Soft tissues remained stable with no statistically significant differences between 6 months and 1 year.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Cell Biology
Yahui Wang, Yong Xu, Guangdong Zhou, Yu Liu, Yilin Cao
Summary: In tissue engineering applications, an acellular dermal matrix (ADM) has been found to be more suitable for cartilage regeneration compared to an acellular cartilaginous matrix (ACM). ADM scaffolds exhibited better cell adhesion rate, more homogeneous chondrocyte distribution, and neocartilage formation. Subcutaneous implantation in a goat showed that ADM achieved more stable and matured cartilage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
My Thi Ngoc Nguyen, Ha Le Bao Tran
Summary: The study aimed to prepare injectable acellular adipose matrix (AAM) through delipidating and decellularizing, showing that mechanical disruption improved fat removal efficiency and the decellularization strategy was effective. AAM powder was non-toxic to human adipose derived stem cells and supported cell migration and proliferation.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2021)
Article
Engineering, Biomedical
Bin Wang, Qinglai Tang, Qian Yang, Mengmeng Li, Shiying Zeng, Xinming Yang, Zian Xiao, Xinying Tong, Lanjie Lei, Shisheng Li
Summary: Due to their unique properties such as low immunogenicity, biomimetic internal environment, tissue-and organ-like physicochemical properties, and functionalization potential, decellularized extracellular matrix (dECM) materials have gained considerable attention in tissue engineering. This review provides an overview of the composition of extracellular matrices and their role in stem-cell differentiation, discusses the advantages and disadvantages of existing decellularization techniques, and presents methods for the functionalization and characterization of decellularized scaffolds. Additionally, the review discusses the progress and shortcomings of using dECMs in cartilage, skin, nerve, and muscle repair, as well as the transplantation or regeneration of different whole organs, and examines the future prospects of refunctionalization in tissue and organ repair. It aims to systematize the application of functionalized dECMs in tissue/organ transplantation and keep researchers informed about the latest progress in dECM usage.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Marcin Gierek, Wojciech Labus, Diana Kitala, Andrzej Lorek, Gabriela Ochala-Gierek, Karolina Mikus Zagorska, Dariusz Waniczek, Karol Szyluk, Pawel Niemiec
Summary: Reconstructive surgery often deals with large tissue defects and requires materials that are both immunogenic but offer tissue filling. ADM, an acellular dermal matrix, is a commonly used biological collagen matrix without immunogenicity. This literature review examines the use of human ADM in reconstructive surgery across different fields, emphasizing the need for further research in this area.
Article
Engineering, Biomedical
Bing Zhang, Li Ma, Lian Sheng Tang, Da Wei Song, Jing Guo, Fan Zhang, Xin Xu
Summary: This study evaluated the effects of a modified porcine acellular dermal matrix (P-ADM), subepithelial connective tissue graft (SCTG), and other commercial bovine acellular dermal matrix membrane materials (B-ADM) on gingival soft tissue augmentation in the oral esthetic zone. The results showed that P-ADM had good cytocompatibility and no cytotoxicity, and it could be used as an alternative biomaterial for oral soft tissue thickening.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Surgery
Andreas Pabst, Keyvan Sagheb, Sebastian Blatt, Kawe Sagheb, Saskia Schroeger, Stefan Wentaschek, Sven Schumann
Summary: This study found significant differences in the biomechanical properties and architectural features between autogenous soft tissue grafts (ASG) and acellular dermal matrices (ADM).
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Danni Gong, Fei Yu, Meng Zhou, Wei Dong, Dan Yan, Siyi Zhang, Yan Yan, Huijing Wang, Yao Tan, Ying Chen, Bei Feng, Wei Fu, Yao Fu, Yang Lu
Summary: dcECM hydrogels derived from porcine ears through enzymatic digestion show good biocompatibility for delivering chondrocytes and forming subcutaneous cartilage in vivo. The structural and gelation kinetics of the hydrogels vary with ECM concentrations, with 10 mg/ml hydrogels supporting adhesion and proliferation of chondrocytes in vitro. In vivo, 10 mg/ml dcECM hydrogel grafts exhibit similar qualities to native cartilage, indicating their potential for tissue engineering applications in ear cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Baozhen Zhang, Yue Zhang, Yidan Wang, Fan Yang, Shiyun Sheng, Zhe Wang, Xiaoying Chang, Jianyu Wei, Jintao Guo, Siyu Sun
Summary: This study found that using FCSEMS combined with ADM can enhance re-epithelization after ESD, and significantly reduce the degree of esophageal stenosis. The findings of this study are important preclinical findings for subsequent clinical trials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Physiology
Jan Mihalecko, Martin Bohac, Lubos Danisovic, Jan Koller, Ivan Varga, Marcela Kuniakova
Summary: This article provides a brief review of the current literature assessing the clinical applications of ADM, a widely used material in plastic and reconstructive surgery, which promotes healing process and reduces scar tissue formation.
PHYSIOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Joo Yeon Park, Jae Hee Chung
Summary: This is a case of giant omphalocele that was successfully repaired using surgical intervention. During the operation, there was dehiscence at the suture site, which was repaired using synthetic absorbable mesh. Using acellular porcine dermal matrix can be considered as a viable treatment option for repairing omphaloceles.
Article
Biotechnology & Applied Microbiology
Huiming Jiang, Jun Lu, Jiawei Li, Zizheng Liu, Fufei Chen, Rui Wu, Xingquan Xu, Yuan Liu, Yiqiu Jiang, Dongquan Shi
Summary: A novel acellular cartilage matrix scaffold (ACS) was designed for cartilage regeneration and hyaline-like cartilage formation. The results showed that ACS implantation promoted cartilage repair in full-thickness cartilage defects and osteochondral defects, forming more hyaline-like cartilage at the 6-month follow-up.
Review
Dermatology
Linda Tognetti, Elisa Pianigiani, Francesca Ierardi, Guido Lorenzini, Donato Casella, Flavio Giulio Liso, Andrea De Pascalis, Elisa Cinotti, Pietro Rubegni
Summary: The use of human acellular dermal matrices (hADMs) at different body sites provides several advantages, including protection of deep structures, stimulation of functional new dermis, reduced wound closure time, and control of pain and exudate.
DERMATOLOGIC THERAPY
(2021)
Article
Health Care Sciences & Services
Irina F. Dragan, Tanya Wright, Lucrezia Paterno Holtzman, Federico Ausenda, Umer Malik, Nawwaf Al-Hamoudi, Nadeem Karimbux, Mohammed Alasqah
Summary: This study evaluated the use of Omega-3 piscine acellular dermal matrix (OADM) as a soft tissue alternative in surgically created mucogingival defects. The results showed that the use of this alternative resulted in normal healing with minimal complications.
TECHNOLOGY AND HEALTH CARE
(2022)
Article
Chemistry, Multidisciplinary
Young-Joo Lee, Suhail K. Kanchwala, Hyesung Cho, Jason Christopher Jolly, Eric Jablonka, Michael Tanis, Randall D. Kamien, Shu Yang
Summary: To achieve successful and aesthetic breast reconstruction for breast cancer survivors, acellular dermal matrices (ADMs) are commonly used. However, traditional ADM sheets cannot fully cover breast implants without wrinkles. In this study, a kirigami strategy is proposed to cut ADM sheets with controlled stretchability, curvature, and elasticity. This approach allows for better conformity and support for reconstructed breasts, offering potential benefits in terms of outcomes and cost efficiency.
ADVANCED MATERIALS
(2023)