Review
Biochemistry & Molecular Biology
Hubert Aleksandrowicz, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Summary: The prevalence of venous leg ulcers (VLUs) ranges from 1.5% to 3% in the general population, with common challenges being recurrence and resistance to healing. New technologies, such as biophysical interventions and advanced wound therapies, have been increasingly used in treating VLUs in recent years.
Article
Dermatology
Jennifer Jahel Velez Gonzalez, Maximilian Berger, Stefan Schiele, Anna Rubeck, Gernot Mueller, Julia Welzel, Sandra Schuh
Summary: This study investigated the use of D-OCT for evaluating blood vessel morphology and density in venous ulcers and found that it can provide new information about vascular changes during the healing process.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Jodi Christine McDaniel, Bohyun Kim, Dina Rose McGowan
Summary: Determining the role of molecular factors in venous leg ulcer exudate is crucial for identifying biomarkers that can guide treatment. However, there is no standardized approach for collecting, processing, and storing wound fluid samples. This scoping review identified heterogeneous methods used in studies of venous leg ulcers and highlighted the need for standardized sampling methods to facilitate accurate comparisons and rapid determination of biomarkers.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Olga Krizanova, Adela Penesova, Alica Hokynkova, Andrea Pokorna, Amir Samadian, Petr Babula
Summary: Chronic venous disease is a condition that affects the veins in the lower extremities, characterized by impaired blood return. This review discusses the etiology, risk factors, and pathophysiology of venous leg ulcers (VLU), and compares the treatment options.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Khi Yung Fong, Tina Peiting Lai, Kai Siang Chan, Isabel Jia Le See, Cheng Cheng Goh, Sivakami Muthuveerappa, Audrey Huimin Tan, Shanying Liang, Zhiwen Joseph Lo
Summary: The study aims to validate the accuracy of a smartphone wound application in Asian patients with venous leg ulcers. The results show that Tissue Analytics application is a useful adjunct for wound assessment and surveillance in this population.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Infectious Diseases
Ilaria Cavallo, Ilaria Lesnoni La Parola, Francesca Sivori, Luigi Toma, Tatiana Koudriavtseva, Isabella Sperduti, Daniela Kovacs, Giovanna D'Agosto, Elisabetta Trento, Norma Cameli, Anna Mussi, Alessandra Latini, Aldo Morrone, Fulvia Pimpinelli, Enea Gino Di Domenico
Summary: This study analyzed clinical data and laboratory parameters of patients with infected and noninfected chronic venous leg ulcers (VU). The results showed that infected ulcers had increased size and depth and higher levels of inflammatory cytokines. Hyperhomocysteinemia was more common in infected ulcers, and Gram-negative bacteria and strong biofilm producers were predominant in the infection.
Article
Dermatology
Klaus Kirketerp-Moller, Petra Doerfler, Nicole Schoefmann, Barbara Wolf-Winiski, Omid Niazi, Vibeke Pless, Tonny Karlsmark, Magnus Agren
Summary: This exploratory study aimed to investigate the association between biomarkers in wound fluid and the healing of split-thickness skin grafts in venous leg ulcers. The study found that the concentration of matrix metalloproteinase-9 in wound fluid was higher in venous leg ulcers showing good healing compared to those with poor healing.
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Ewa A. Burian, Lubna Sabah, Tonny Karlsmark, Klaus Kirketerp-Moller, Christine J. Moffatt, Jacob P. Thyssen, Magnus S. Agren
Summary: This systematic review investigated the association between cytokine levels and the healing of venous leg ulcers (VLUs). The findings suggest that non-healing VLUs may be associated with elevated pro-inflammatory cytokine levels, which decline with healing. TGF-beta 1 levels tended to increase with VLU healing. Further research is needed to explore other cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Kai Siang Chan, Shanying Liang, Yuan Teng Cho, Yam Meng Chan, Audrey Hui Min Tan, Sivakami Muthuveerappa, Tina Peiting Lai, Cheng Cheng Goh, Annie Joseph, Qiantai Hong, Enming Yong, Li Zhang, Lester Rhan Chaen Chong, Glenn Wei Leong Tan, Sadhana Chandrasekar, Zhiwen Joseph Lo
Summary: The study investigated the intra- and inter-rater reliability of the WA imaging system in patients with venous leg ulcers, demonstrating high reliability of the system and excellent consistency with traditional measurement methods.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Medicine, General & Internal
Cibele T. D. Ribeiro, Fernando A. L. Dias, Guilherme A. F. Fregonezi
Summary: The effectiveness of hydrogel dressings for treating venous leg ulcers remains uncertain. More research is needed to determine the efficacy of hydrogel dressings compared to gauze and saline, alginate dressing, manuka honey, or hydrocolloid in promoting the healing of venous leg ulcers.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Medicine, General & Internal
C. D. Weller, Victoria Team, Sebastian Probst, Georgina Gethin, Catelyn Richards, Jane Sixsmith, Louise Turnour, Ayoub Bouguettaya
Summary: This scoping review aims to examine the level of health literacy in VLU patients and how it may link to self-management behaviors, particularly exercise and compression adherence, and their overall VLU healing.
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Dermatology
Vincent Maida, Runjie Bill Shi, Francesco Gabriele Tatangelo Fazzari, Lydia Zomparelli
Summary: Venous leg ulcers, a common lower limb wound, are difficult to heal even with evidence-based compression therapies. Topical Cannabis-Based Medicines show promise in promoting wound closure for complex patients with these ulcers, but further controlled trials are needed.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Nuraini Nazeha, Jia Yi Lee, Seyed Ehsan Saffari, Lingyan Meng, Pei Ho, Yi Zhen Ng, Nicholas Graves
Summary: Healthcare costs arising from venous leg ulcers (VLU) are expected to increase. This study estimated the healthcare resources incurred by VLU patients and examined the predictors explaining variation in cost-related outcomes.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Multidisciplinary Sciences
Quoc Cuong Ngo, Rajna Ogrin, Dinesh Kant Kumar
Summary: This study proposed a computerised prediction framework for healing of venous leg ulcers using thermal images, with textural features from the thermal images at week 0 being used to discriminate between healed and unhealed wounds. The optimal Bayesian neural network achieved 78.57% sensitivity and 60.00% specificity in classifying healing outcomes. This non-contact method incorporating machine learning provides earlier prediction compared to current methods requiring contact digital planimetry.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Agata Janowska, Giulia Davini, Marco Romanelli, Oranges Teresa, Iannone Michela, Valentina Dini
Summary: This study aimed to evaluate the bacterial environment on wound beds using fluorescence and color captured by MolecuLight i:X device and correlate them with average pH values and wound bed scores. Significant associations were found between fluorescence and pH values, and MolecuLight i:X was able to objectively detect bacterial proliferation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Letter
Infectious Diseases
Angelo Massimiliano D'Erme, Cristian Fidanzi, Agata Janowska, Valentina Dini, Marco Romanelli, Vanna Zucchi, Paolo Viacava, Giovanni Bagnoni
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Letter
Infectious Diseases
Angelo Massimiliano D'Erme, Cristian Fidanzi, Giovanni Bagnoni, Simone Pardossi, Flavia Manzo Margiotta, Agata Janowska, Valentina Dini, Marco Romanelli
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Dermatology
Cristian Fidanzi, Giulia Davini, Valentina Dini, Giammarco Granieri, Antonella Vietina, Marco Romanelli, Agata Janowska
Summary: Squamous cell carcinoma is a rare and malignant skin cancer, with bone infiltration and invasion of the dura mater being uncommon. This article describes the management of advanced scalp squamous cell carcinoma involving bones and meninges. The patient received palliative care and various dressings were used to control wound exudate and infection.
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2022)
Article
Parasitology
Teresa Oranges, Stefano Veraldi, Giammarco Granieri, Cristian Fidanzi, Agata Janowska, Valentina Dini, Marco Romanelli
Summary: A wide range of parasites can infect wounds or cause wounds through infection. Proper wound treatment is essential to reduce pathological scars and prevent complications, and the use of appropriate debridement, topical antiseptics, and dressings can help control infection, moisture, inflammation, and promote wound edge proliferation.
Article
Dermatology
Michela Iannone, Agata Janowska, Salvatore Panduri, Riccardo Morganti, Giulia Davini, Marco Romanelli, Valentina Dini
Summary: The interaction between the immunological and nervous system in the skin has a significant impact on patients with psoriasis, atopic dermatitis, and hidradenitis suppurativa. Psychodermatological interventions can improve quality of life, disease flare-ups, and long-term management for these patients.
EXPERIMENTAL DERMATOLOGY
(2022)
Letter
Infectious Diseases
Cristian Fidanzi, Agata Janowska, Marco Romanelli, Angelo Massimiliano D'Erme, Giovanni Bagnoni, Valentina Dini
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Dermatology
Agata Janowska, Giulia Davini, Michela Iannone, Cristian Fidanzi, Riccardo Morganti, Marco Romanelli, Valentina Dini
Summary: The MolecuLight i:X device is a portable autofluorescence device that allows for real-time evaluation of wound area, perimeter, width, length, and wound surface bacteria. The study aimed to assess the reduction of bacterial load with different therapeutic approaches and evaluate pain scale, wound bed score, and quality of life. The results demonstrate that the application of zinc oxide bandage directly on the wound significantly improves wound bed score and reduces bacterial load.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Medicine, General & Internal
Eugenia Piragine, Davide Petri, Alma Martelli, Agata Janowska, Valentina Dini, Marco Romanelli, Vincenzo Calderone, Ersilia Lucenteforte
Summary: Adherence and persistence to biologics in psoriasis patients are sub-optimal, with significant differences between different drugs. A more rational use of biologics might ensure better management of psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Agata Janowska, Michela Iannone, Cristian Fidanzi, Marco Romanelli, Luca Filippi, Marzia Del Re, Manuella Martins, Valentina Dini
Summary: This paper reviews the genetic profile of melanoma cells from their appearance, through the dormant state to their reactivation leading to metastasis. A complete genetic profile will identify the genes responsible for metastasis appearance, contributing to the creation of new therapeutic targets that keep cells in a dormant state and prevent melanoma tumor cells from spreading.
Article
Dermatology
M. Augustin, P. G. Sator, R. von Kiedrowski, C. Conrad, D. Rigopoulos, M. Romanelli, P-D Ghislain, T. Torres, D. Ioannides, M. Aassi, B. Schulz, P. Jagiello
Summary: Secukinumab demonstrates long-term effectiveness and favorable safety in the treatment of moderate-to-severe plaque-type psoriasis patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Dermatology
Marco Romanelli, Flavia Manzo Margiotta, Alessandra Michelucci, Giammarco Granieri, Agata Janowska, Valentina Dini
Summary: Compression therapy provides valuable support for vascular and inflammatory lower leg skin disorders. Recent findings show its potential benefits in treating atypical wounds and improvements in adherence to treatment. Physicians should be aware of the advantages of compression therapy in managing skin diseases.
CURRENT DERMATOLOGY REPORTS
(2023)
Article
Medicine, General & Internal
Alessandra Michelucci, Valentina Dini, Giorgia Salvia, Giammarco Granieri, Flavia Manzo Margiotta, Salvatore Panduri, Riccardo Morganti, Marco Romanelli
Summary: This study used ultra-high-frequency ultrasound to monitor the changes in nail bed and matrix in patients with psoriatic onychopathy during monoclonal antibody treatment. The results showed a significant decrease in some parameters after treatment. Therefore, ultra-high-frequency ultrasound could be a valuable technique for evaluating and monitoring psoriatic onychopathy.
Article
Dermatology
Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini
Summary: This study aimed to assess the correlation between serum amyloid A (SAA) levels and various factors in Hidradenitis suppurativa (HS) patients. The results showed that SAA levels were associated with number of nodules, abscesses, fistulas, and severe IHS4. Gluteal localization was also correlated with high values of mSartorius and severe IHS4. Therefore, monitoring SAA levels in HS patients is recommended to prevent disease flare-ups and potential complications.
SKIN APPENDAGE DISORDERS
(2023)
Letter
Dermatology
Christos C. Zouboulis, Errol P. Prens, Christopher J. Sayed, Alejandro Molina-Leyva, Vincenzo Bettoli, Marco Romanelli, Jacek C. Szepietowski, Angela Llobet Martinez, Torben Kasparek, Iryna Lobach, Magdalena B. Wozniak, Christine-Elke Ortmann, Nicolas Thomas, Teresa Bachhuber, Shoba Ravichandran, Thrasyvoulos Tzellos
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
