Article
Chemistry, Applied
Elnaz Ahani, Majid Montazer, Ali Mianehro, Nasrin Samadi, Tayebeh Toliyat, Mahnaz Mahmoudi Rad
Summary: A novel method for controlled release of PHMB is introduced by encapsulating it into cationic liposomes and permeating them into wool. The prepared wound dressings showed highly sustained release for days, and subsequently exhibited long-term perfect antibacterial activity and biocompatibility.SEM images confirmed the successful transmission of cationic-liposome-encapsulated PHMB into the wool.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Polymer Science
Pichapar O-chongpian, Tanpong Chaiwarit, Kittisak Jantanasakulwong, Pornchai Rachtanapun, Patnarin Worajittiphon, Nutthapong Kantrong, Pensak Jantrawut
Summary: The hydrophilicity of cellulose nanofibers was enhanced through surface modification using a TEMPO/NaBr/NaClO system. Hydrogels loaded with carboxylated cellulose nanofibers and polyhexamethylene biguanide were fabricated using physical crosslinking method, which showed desirable characteristics and prolonged drug release. The integration of PHMB into the hydrogel matrix was confirmed, and the formulation exhibited antibacterial activity against S. aureus and P. aeruginosa.
Article
Ophthalmology
Otavio de Azevedo Magalhaes, Debora Ribeiro dos Santos, Bruno Guilherme Coch Broetto, Gertrudes Corcao
Summary: The objective of this study was to compare the antimicrobial action of commercially available multipurpose disinfection solutions (MPDS) with and without hydrogel contact lens for disinfection of isolated corneal bacteria. The results showed that MPDS containing dual biocides polyquaternium-1 and myristamidopropyl dimethylamine possess the highest disinfection action against multiple ocular pathogens with and without contact lenses.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2023)
Article
Surgery
Mike Ralf Langenbach, Razvan-Valentin Florescu, Andreas Koehler, Joerg Barkus, Jorg-Peter Ritz, Eduart Quemalli, Robert Siegel, Hubert Zirngibl, Rolf Lefering, Lars Boenicke
Summary: This multicentre, randomized clinical trial suggests that omitting tamponade dressings after haemorrhoidectomy can reduce postoperative pain without increasing the risk of severe bleeding.
Article
Biochemistry & Molecular Biology
Xun Wang, Donghui Zhao, Yuting Li, Xinpei Zhou, Zexuan Hui, Xiaoling Lei, Lin Qiu, Yang Bai, Cheng Wang, Jiang Xia, Yang Xuan, Pengju Jiang, Jianhao Wang
Summary: Wound infection by multidrug-resistant bacteria is a serious threat to human life. Chronic wounds, characterized by necrosis, persistent inflammation, and hypoxic tissue, pose significant challenges to anti-infection treatments. Therefore, a multifunctional hydrogel dressing has been developed to address these issues and promote wound healing. The hydrogel incorporates antimicrobial peptides, liposome-encapsulated oxygen carrier, and recombinant collagen, providing multiple antimicrobial mechanisms and improved healing for chronic wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
Ran Zhao, Chenyuyao Zhao, Yushen Zhang, Yi Wan, Yibing Wang
Summary: This study retrospectively reviewed cases from the past 5 years and found that bacterial cellulose dressing had better outcomes compared to allogenic skin in paediatric burn wounds after dermabrasion surgery. The BCD group had longer surgery time, shorter healing time, fewer dressing changes, and lower rates of skin grafting.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jean Lucas Tanaka, Caroline Barcelos Costa-Orlandi, Betina Sayeg Burd, Giovana Sant'Ana Pegorin, Thaina Venancio da Silva, Nayrim Brizuela Guerra, Maria Jose Soares Mendes-Giannini, Ana Marisa Fusco-Almeida, Rondinelli Donizetti Herculano, Natan Roberto de Barros
Summary: An inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds, showing no interaction between drug and biopolymer in the infrared spectrum. The curative exhibited good mechanical properties, antifungal effects, and biocompatibility, representing a promising alternative for burn wound treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Chen Zhou, Zhifei Yang, Xiaowei Xun, Le Ma, Zejing Chen, Xiaoming Hu, Xidong Wu, Yizao Wan, Haiyong Ao
Summary: A multifunctional dressing consisting of collagen I and an antibacterial agent has been developed to treat and promote the healing of infected wounds. The dressing showed excellent antibacterial properties and cell compatibility, and significantly improved water retention compared to existing options.
BIOACTIVE MATERIALS
(2022)
Review
Dermatology
Nick Santamaria, Kevin Woo, Dimitri Beeckman, Paulo Alves, Breda Cullen, Amit Gefen, Jose Luis Lazaro-Martinez, Hadar Lev-Tov, Bijan Najafi, Andrew Sharpe, Terry Swanson
Summary: The aim of this article is to identify and describe clinical practice performance characteristics for bordered foam dressings in the treatment of complex wounds. Our hope is that by highlighting the clinical performance criteria, future testing standards for wound dressings will more closely match our clinical expectations and assist clinicians to make better wound treatment choices based on meaningful and clinically relevant dressing product performance standards.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Jing Liu, Hong Shen
Summary: This retrospective study explored the clinical efficacy of chitosan-based hydrocolloid dressing in treating chronic refractory wounds. The results showed that chitosan-based hydrocolloid dressing significantly improved wound healing, reduced pain and itching, and decreased the overall cost and frequency of dressing change.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Karan Razdan, Jorge Garcia-Lara, V. R. Sinha, Kamalinder K. Singh
Summary: This review focuses on the mechanism of biofilm formation and the role of biofilms in chronic wounds, as well as various formulation strategies and delivery systems used to eradicate or disperse biofilms. The clinical research on the treatment of biofilm-infected chronic wounds is also discussed.
DRUG DISCOVERY TODAY
(2022)
Article
Engineering, Biomedical
C. K. Nanditha, G. S. Vinod Kumar
Summary: This study reports the potential application of a nanofibrous mat enriched with bioactive peptides as an effective wound dressing for diabetic wounds. The material, fabricated using electrospinning, promotes accelerated wound healing, cell proliferation, and migration through the incorporation of bioactive peptides.
MATERIALS TODAY BIO
(2022)
Article
Pharmacology & Pharmacy
Vignesh Mohan, Sarika Wairkar
Summary: The objective of this study was to develop a topical foam formulation of mupirocin for the prevention and treatment of skin wounds, particularly burn wounds. The foam formulation showed a quick collapse time, good spreadability, and superior antibacterial efficacy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Xiao Yue, Xuejuan Zhang, Chen Wang, Ying Huang, Ping Hu, Guanlin Wang, Yingtong Cui, Xiao Xia, Ziqiang Zhou, Xin Pan, Chuanbin Wu
Summary: A lyotropic liquid crystal-based bacteria-resistant and self-healing spray dressing loaded with epsilon-polylysine (PLL) was designed to effectively kill antibiotic-resistant bacteria and promote wound healing. The dressing demonstrated excellent antibacterial activity and mechanical properties, making it a promising candidate for therapy of infected post-operative wounds.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Medicine, General & Internal
Hanna Luze, Ives Bernardelli de Mattos, Sebastian Philipp Nischwitz, Martin Funk, Alexandru Cristian Tuca, Lars-Peter Kamolz
Summary: In this study, the antimicrobial activity of antiseptic-loaded bacterial nanocellulose (BNC) against in vitro biofilms was investigated. The results showed that BNC loaded with Octenisept (R) could completely eradicate Staphylococcus aureus biofilm, while BNC loaded with Octenisept (R) or Prontosan (R) could also eliminate Candida albicans biofilm.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Dermatology
R. Gary Sibbald, Elizabeth A. Ayello, Heather L. Orsted
INTERNATIONAL WOUND JOURNAL
(2008)
Editorial Material
Dermatology
R. Gary Sibbald, Kevin Y. Woo
INTERNATIONAL WOUND JOURNAL
(2008)
Article
Dermatology
R. Gary Sibbald, Pat Coutts, Linda Norton, Todd Nicholson
INTERNATIONAL WOUND JOURNAL
(2008)
Editorial Material
Dermatology
R. Gary Sibbald, Linda Norton, Kevin Y. Woo
ADVANCES IN SKIN & WOUND CARE
(2009)
Article
Dermatology
R. Gary Sibbald, Diane L. Krasner, Kevin Y. Woo
ADVANCES IN SKIN & WOUND CARE
(2011)
Article
Dermatology
R. Gary Sibbald, Elizabeth A. Ayello, Hiske Smart, Laurie Goodman, Brian Ostrow
ADVANCES IN SKIN & WOUND CARE
(2012)
Article
Dermatology
R. Gary Sibbald, Elizabeth A. Ayello, Afsaneh Alavi, Brian Ostrow, Julia Lowe, Mariam Botros, Laurie Goodman, Kevin Woo, Hiske Smart
ADVANCES IN SKIN & WOUND CARE
(2012)
Article
Dermatology
R. Gary Sibbald, Liza G. Ovington, Elizabeth A. Ayello, Laurie Goodman, James A. Elliott
ADVANCES IN SKIN & WOUND CARE
(2014)