Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
Summary: This study analyzed the clinical characteristics of diabetic inpatients with foot ulcers and explored the risk factors for lower extremity amputation. The study found that diabetic patients with amputation were older, had longer duration of diabetes, poor glycemic control, malnutrition, peripheral arterial disease, and severe foot ulcers with infection. A history of prior amputation, foot gangrene, and low ankle brachial index were independent predictors of lower extremity amputation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dermatology
Ka-Huen Yip, Yuk-Chiu Yip, Wai-King Tsui
Summary: This study explored the thoughts and experiences of patients with diabetic foot ulcers in Hong Kong regarding lower-limb amputation. It found that lower-limb amputation is considered a forbidden topic, making it culturally difficult for Chinese patients to discuss the matter with healthcare authorities and family members. Healthcare workers should be aware of how they communicate regarding lower-limb amputation.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Laurens Manning, Ivana Bastos Ferreira, Paul Gittings, Jonathan Hiew, Erica Ryan, Mendel Baba, Edward Raby, Keryln Carville, Paul E. Norman, Wendy Angela Davis, Fiona Wood, Emma Jane Hamilton, Jens Carsten Ritter
Summary: Spray-on skin treatment showed high rates of complete healing at 6 months in patients with large diabetes-related foot wounds, but was not significantly better than standard care. Lower body mass index and non-plantar wounds were the only patient- or wound-related factors associated with complete healing at 6 months.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Immunology
Hadar Mudrik-Zohar, Shaqed Carasso, Tal Gefen, Anat Zalmanovich, Michal Katzir, Yael Cohen, Yossi Paitan, Naama Geva-Zatorsky, Michal Chowers
Summary: Sequencing tools uncover the complex biodiversity of IDFU and highlight the high prevalence of anaerobes and Gram-negative bacteria in these ulcers. Furthermore, sequencing results reveal possible associations among certain genera, species, and bacterial functional genes to clinical outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jeong Hyun Ha, Heejin Jin, Ji-Ung Park
Summary: The study found that low socioeconomic position is strongly associated with increased amputation and mortality rates in diabetic foot ulcer patients, serving as an important predictor of these outcomes.
Article
Dermatology
Mesut Demirkoparan, Arman Vahabi, Berker Ozbek, Merve Mert, Ilgin Yildirim Simsir, Hueseyin Aytac Erdem, Anil Murat Ozturk, Sevki Cetinkalp
Summary: Amputations related to diabetic foot ulcers (DFU) are associated with high morbidity and mortality rates. The study compared the outcomes of DFU patients admitted before and after COVID-19 restrictions and found that there was no significant difference in mortality and amputation rates between the two groups. The number of emergent cases during the pandemic doubled compared to the pre-pandemic period, but this finding was not statistically significant. Fast adaptation of consulting practice and follow-up protocols seemed to compensate for the challenges posed by COVID-19 regulations.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Rebecca A. Burmeister, Christine Jarocki, Crystal M. Holmes, Gary M. Rothenberg, Michael E. Munson, Brian M. Schmidt
Summary: The study found that patients discharged to skilled nursing facilities after diabetes-related limb salvage surgery had longer healing time, increased risk of rehospitalization and subsequent major lower-extremity amputation on the same side, as well as a higher mortality rate compared to patients discharged home.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Dermatology
Xiaofeng Peng, Dengqun Gou, Lu Zhang, Hemei Wu, Yu Chen, Xing Shao, Li Li, Ming Tao
Summary: This study aimed to investigate the influencing factors of lower limb amputation in patients with diabetic foot ulcers. Retrospective data of patients with diabetic foot ulcers hospitalized in a tertiary general hospital in Guizhou Province from January 2019 to March 2022 were collected and analyzed. The results showed that decreased levels of HDL cholesterol were associated with a higher risk of lower limb amputation in patients with diabetic foot ulcers. The findings suggest that decreased HDL cholesterol levels can serve as an independent predictor of amputation in this patient population.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Engineering, Biomedical
Cara G. Welker, Vincent L. Chiu, Alexandra S. Voloshina, Steven H. Collins, Allison M. Okamura
Summary: By using a wrist exoskeleton, this system allows individuals with amputation to control and receive feedback from an ankle-foot prosthesis, showing accuracy comparable to human neuromotor control. Benchtop testing demonstrated low system error, while experimental results showed that participants were able to track different wrist trajectories during walking.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Review
Endocrinology & Metabolism
Hakan Dogruel, Mustafa Aydemir, Mustafa Kemal Balci
Summary: Diabetic foot ulcers are one of the most challenging complications of diabetes, with about one-third of diabetes patients affected. The disease has a high recurrence rate, highlighting the importance of prevention strategies. A multidisciplinary approach is necessary for treatment, including preventive measures based on patient risk and appropriate treatment interventions.
WORLD JOURNAL OF DIABETES
(2022)
Article
Multidisciplinary Sciences
H. Anita, A. Manoj, N. Arunagirinathan, M. R. Rameshkumar, K. Revathi, R. Selvam, T. Kannan, N. M. Darwish, D. A. Al Farraj, M. R. Abdelgawwad
Summary: This study analyzed the bacterial etiology, antibiotic resistance profile, and clinical outcomes of foot ulcer-associated amputations in persons with diabetes. The results showed that Gram-negative bacteria were the major pathogens causing amputations, and the incidence of multi-drug resistant bacteria associated with foot ulcers could limit the availability of antibiotic treatments.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Medicine, General & Internal
Andrei Ardelean, Diana-Federica Balta, Carmen Neamtu, Adriana Andreea Neamtu, Mihai Rosu, Luminita Pilat, Silviu Moldovan, Cristi Tarta, Bogdan Totolici
Summary: Strategies have been researched and implemented to reduce the number of people with diabetic foot ulcers (DFUs). Accurate assessment of DFU severity is a challenge for resource allocation and treatment choice. This study focused on assessing pentraxin-3 as a biomarker for infected DFUs (IDFUs) and evaluating other markers such as white blood cells, C-reactive protein, erythrocyte sedimentation rate, and procalcitonin for identifying IDFUs.
Article
Dermatology
Fran Game, Katie Gray, Daniel Davis, Rachelle Sherman, Kamal Chokkalingam, Zak Connan, Apostolos Fakis, Michael Jones
Summary: Recent reviews indicate that amniotic membrane products could potentially aid in the accelerated healing of diabetic foot ulcers. A pilot trial testing the addition of dried human amniotic membrane (dHAM) to standard care for diabetic foot ulcers showed promising results, with a higher healing rate and percentage wound area reduction in the dHAM group compared to standard care group. This suggests that dHAM preparation may be a safe and effective treatment option for diabetic foot ulcers.
INTERNATIONAL WOUND JOURNAL
(2021)
