Journal
ACS COMBINATORIAL SCIENCE
Volume 16, Issue 3, Pages 93-100Publisher
AMER CHEMICAL SOC
DOI: 10.1021/co400144b
Keywords
aldehydes; anilines; quinolines; ionic liquid; three-component reaction
Funding
- Center of Excellence of Chemistry
- Research Council of the University of Isfahan
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The synthesis of a variety of 2,3-disubstituted quinolines has been achieved successfully via a one-pot three-component reaction of arylamines, arylaldehydes and aliphatic aldehydes in the presence of butylpyridinium tetrachloroindate-(III), [bpy][InCl4], ionic liquid as a green catalyst and solvent. Mild conditions with excellent conversions, and simple product isolation procedure are noteworthy advantages of this method. The recyclability of the ionic liquid makes this protocol environmentally benign.
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