Journal
ACS CATALYSIS
Volume 8, Issue 10, Pages 9125-9130Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b02645
Keywords
nitriles; primary amines; secondary aldimines; cobalt catalysts; hydrogenation; hydrogenative coupling
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Funding
- National Science Foundation [CHE-1464734]
- University of Cincinnati (Doctoral Enhancement Research Fellowship)
- Division Of Chemistry [1464734] Funding Source: National Science Foundation
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Previous studies of base metals for catalytic hydrogenation of nitriles to primary amines or secondary aldimines focus on designing complexes with elaborate structures. Herein, we report twin catalytic systems where the selectivity of nitrile hydrogenation can be tuned by including or omitting the ligand HN-((CH2CH2PPr2)-Pr-i)(2) ((PNP)-P-iPr-P-H). Simply treating CoBr2 with NaHBEt3 generates cobalt particles, which can catalyze the hydrogenation of nitriles to primary amines with high selectivity and broad functional group tolerance. Ligating CoBr2 with (PNP)-P-iPr-P-H followed by the addition of NaHBEt3, however, forms a homogeneous catalyst favoring secondary aldimines for both hydrogenation and hydrogenative coupling of benzonitrile.
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