Theoretical Study of the Free Energy Surface and Kinetics of the Hepatitis C Virus NS3/NS4A Serine Protease Reaction with the NS5A/5B Substrate. Does the Generally Accepted Tetrahedral Intermediate Really Exist?

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Title
Theoretical Study of the Free Energy Surface and Kinetics of the Hepatitis C Virus NS3/NS4A Serine Protease Reaction with the NS5A/5B Substrate. Does the Generally Accepted Tetrahedral Intermediate Really Exist?
Authors
Keywords
-
Journal
ACS Catalysis
Volume 5, Issue 1, Pages 246-255
Publisher
American Chemical Society (ACS)
Online
2014-12-05
DOI
10.1021/cs5011162

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