Journal
ACS CATALYSIS
Volume 3, Issue 4, Pages 685-688Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cs400019u
Keywords
asymmetric; copper carbene; [4+1] cycloadditions; dihydrofurans
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Funding
- National Natural Sciences Foundation of China [21121062, 20932008, 21272250]
- Major State Basic Research Development Program [2009CB825300]
- Chinese Academy of Sciences
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Highly efficient synthesis of chiral tetrasubstituted 2,3-dihydrofuran derivatives has been realized by Cu-catalyzed asymmetric [4 + 1] cycloadditions of alpha-benzylidene-beta-ketoester with a diazo compound. Following this methodology, a series of optically active multifunctionalized dihydrofurans were prepared in high yield with up to 96% ee and 99/1 dr.
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