Journal
ACS CATALYSIS
Volume 1, Issue 1, Pages 29-31Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cs100024n
Keywords
annulation; 3-arylindole; alkynes; nitrosoarenes; gold catalysis
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Funding
- Louisiana Board of Regents
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We have successfully developed a Au-catalyzed annulation method to produce substituted 3-arylindoles from the reaction of nitrosoarenes with arylsubstituted acetylenes under reductive conditions using sodium borohydride. Terminal alkynes reacted better than non-terminal ones with various substituted nitrosoarenes to afford regioselective 3-substituted indoles. This method is simple and straightforward and can be applied successfully to the synthesis of highly substituted indoles.
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