Article
Virology
Sarah Keep, Phoebe Stevenson-Leggett, Giulia Dowgier, Katalin Foldes, Isobel Webb, Albert Fones, Kieran Littolff, Holly Everest, Paul Britton, Erica Bickerton
Summary: Infectious bronchitis virus is a significant concern for the global poultry industry. Live-attenuated vaccines are generated by serial passage of a virulent isolate in embryonated eggs until attenuation is achieved. However, the exact mechanisms of attenuation are unknown and there is a risk of reversion to virulence.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Eliana Icochea, Rosa Gonzalez, Gina Castro-Sanguinetti, Lenin Maturrano, Luis Alzamora, Luiz Sesti, Jorge Chacon, Juan More-Bayona
Summary: This study analyzed 200 samples collected from suspected infected animals in Peru between January and August in 2015, and found circulation of GI-16 and GI-1 lineages of infectious bronchitis virus (IBV). The GI-16 isolates showed unique nucleotide and amino acid changes compared to their closest relatives, suggesting potential relevance for vaccine evasion. These findings highlight the importance of genetic surveillance in improving vaccination strategies against infectious bronchitis.
Review
Veterinary Sciences
Haizhu Li, Gengsong Liu, Qiaoyan Zhou, Hongchun Yang, Congcong Zhou, Weili Kong, Jieyu Su, Gonghe Li, Hongbin Si, Changbo Ou
Summary: Infectious bronchitis virus (IBV) is a significant pathogen in poultry farms that causes various diseases. Based on the classification of the S1 gene, IBV isolates have been categorized into nine genotypes with 38 lineages. This review provides a historical overview of IBV in China, highlights current epidemic strains and licensed vaccines, and discusses prevention and control strategies. The recombinant Newcastle Disease virus (NDV) vector vaccine expressing IBV QX-like and 4/91 strains may be effective against both NDV and IBV.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Vasily Marchenko, Alexey Danilenko, Natalia Kolosova, Maria Bragina, Marina Molchanova, Yuliya Bulanovich, Vladimir Gorodov, Sergey Leonov, Andrey Gudymo, Galina Onkhonova, Svetlana Svyatchenko, Alexander Ryzhikov
Summary: This study found coronaviruses in birds in Russia with a 12% detection rate, including both Gammacoronavirus and Deltacoronavirus. Further research on the spread and diversity of coronaviruses among birds is warranted.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Huiling Gong, Ruiqi Ni, Rongbin Qiu, Fuyan Wang, Wenjun Yan, Kailu Wang, Hao Li, Xue Fu, Liang Chen, Changwei Lei, Hong-ning Wang, Xin Yang
Summary: A recombinant strain of avian infectious bronchitis virus (IBV), CK/CH/MY/2020, was isolated from southwest China. This strain belongs to the GI-28 genotype and is a recombination product of three live attenuated vaccine strains (H120, 4/91, and LDT3-A). Pathogenicity analysis showed that CK/CH/MY/2020 is more virulent than the attenuated vaccine strains.
MICROBIAL PATHOGENESIS
(2022)
Article
Agriculture, Dairy & Animal Science
Wenjun Yan, Rongbin Qiu, Fuyan Wang, Xue Fu, Hao Li, Pengfei Cui, Yaru Zhai, Chun Li, Lan Zhang, Kui Gu, Lei Zuo, Changwei Lei, Hongning Wang, Xin Yang
Summary: Avian infectious bronchitis (IB), caused by avian infectious bronchitis virus (IBV), is a highly contagious disease that poses a serious threat to the poultry industry worldwide. A novel recombinant virus, CK/CH/SCMY/160315, derived from different live attenuated vaccine strains, has led to outbreaks in vaccinated chicken populations in China with various symptoms such as listlessness and sneezing. Pathogenicity analysis confirmed the high infectivity and harmfulness of this new strain.
Article
Virology
Na Xing, Zhisheng Wang, Jichun Wang, Mariana Nascimento, Anan Jongkaewwattana, Jakob Trimpert, Nikolaus Osterrieder, Dusan Kunec
Summary: Reverse genetics systems based on bacterial artificial chromosomes (BACs) are essential tools in coronavirus research. In this study, a reverse genetics system was established for the avian coronavirus strain Beaudette, which is extensively studied. The infectious clone of the Beaudette strain was constructed as a BAC, allowing the recovery of an infectious virus identical to the parental virus. The system was used to generate reporter viruses expressing enhanced green fluorescent protein (EGFP), which can serve as a valuable tool for studying virus replication and developing antiviral drugs.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Liyang Zhao, Yusi Li, Wenjuan Yi, Kuo Yan, Chao Yang, Sridhar Radhakrishnan, Rui Li, Ruirong Tan, Gang Fan, Mengyuan Dai, Miao Liu, Ning-Yi Shao
Summary: This study investigated the impact of different classes of antihypertension drugs on mortality among hospitalized hypertensive patients infected with COVID-19. The results showed that ARB and CCB drugs significantly increased the survival rate, while ACE inhibitors/beta-blockers/diuretics had no effect on COVID-19-related mortality.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Sheng Yuan, Qing Cheng, Jinyue Guo, Zhili Li, Jing Yang, Congying Wang, Zhipeng Liang, Xinyu Zhang, Hai Yu, Yong Li, Shujian Huang, Feng Wen
Summary: This study reports the genetic characteristics of two recent outbreaks of avian infectious bronchitis virus (IBV) in southern China, emphasizing the need for enhanced surveillance and the development of novel vaccines for IBV control.
Article
Agriculture, Dairy & Animal Science
Kamogelo M. Sepotokele, Martha M. O'Kennedy, Michaela C. Hayes, Daniel B. R. Wandrag, Peter Smith, Celia Abolnik
Summary: This article describes a virus-like particle vaccine produced from tobacco plants, which effectively prevents infectious bronchitis caused by Gammacoronavirus. Compared to commercially available vaccines, this vaccine is safer, more affordable, and easier to produce and update to match different viral variants.
Article
Microbiology
Shu-Yun Li, Yu-Xi Shen, Xue-Lian Xiang, Yong-Xin Li, Nian-Ling Li, An-Dong Wang, Min Cui, Xin-Feng Han, Yong Huang, Jing Xia
Summary: The study identified the L1089I substitution in the S2 subunit as a crucial determinant for viral nephrotropism in avian gamma-coronavirus infectious bronchitis viruses (IBV). This substitution significantly attenuated pathogenicity and disrupted viral replication and translation.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Shuyun Li, Wen Chen, Yuxi Shen, Jing Xia, Shunyi Fan, Nianning Li, Yuwen Luo, Xinfeng Han, Min Cui, Yang Zhao, Yong Huang
Summary: The high mutation rate of infectious bronchitis virus (IBV) poses a significant threat to the protective efficacy of vaccines. This study analyzed field strains of IBV isolated in Southwestern China from 2018 to 2020, assessed their pathogenicity, and evaluated the protective efficacy of commercial vaccine strains against these strains. The findings provide important insights for the molecular evolution analysis and control of IBV.
Article
Virology
Sarah Keep, Giulia Dowgier, Valeria Lulla, Paul Britton, Michael Oade, Graham Freimanis, Chandana Tennakoon, Christine Monceyron Jonassen, Torstein Tengs, Erica Bickerton
Summary: Coronaviruses infect many species, including humans and animals, with substantial effects on livestock, particularly with respect to poultry. The roles of the RNA structural elements in the coronavirus genome are poorly understood. This study investigated the requirement of the s2m structure in the replication of infectious bronchitis virus (IBV), a Gammacoronavirus that infects poultry causing respiratory disease. The results showed that deletion of the s2m sequence impacted viral replication and had a preference for nucleotide occupation, independent of the specific s2m sequence.
JOURNAL OF VIROLOGY
(2023)
Article
Virology
Masaji Mase, Kanae Hiramatsu, Satoko Watanabe, Hiroshi Iseki
Summary: The complete nucleotide sequence of the S1 glycoprotein gene of Japanese infectious bronchitis virus (IBV) strains was determined and genetically analyzed. A total of 61 Japanese IBV strains were classified into seven genotypes, and the amino acid polymorphism of the S1 glycoprotein among Japanese genotypes was observed.
Article
Immunology
Sabrina M. Buharideen, Mohamed S. H. Hassan, Shahnas M. Najimudeen, Dongyan Niu, Markus Czub, Susantha Gomis, Mohamed Faizal Abdul-Careem
Summary: The study compared two vaccination strategies in the Canadian poultry industry and found that the second strategy induced better systemic and local host responses in laying hens.
Correction
Genetics & Heredity
Taejoong Kim, Henry D. Hunt, Mark S. Parcells, Vicky van Santen, Sandra J. Ewald
Article
Genetics & Heredity
Taejoong Kim, Henry D. Hunt, Mark S. Parcells, Vicky van Santen, Sandra J. Ewald
Article
Gastroenterology & Hepatology
Grace E. Thaxton, Peter C. Melby, Mark J. Manary, Geoffrey A. Preidis
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2018)
Article
Food Science & Technology
Grace T. Patterson, Lian F. Thomas, Lucy A. Coyne, Jonathan Rushton
GLOBAL FOOD SECURITY-AGRICULTURE POLICY ECONOMICS AND ENVIRONMENT
(2020)
Article
Medicine, General & Internal
Helen E. Clough, K. Marie McIntyre, Grace E. Patterson, John P. Harris, Jonathan Rushton
Summary: This study analyzed routine surveillance data in the UK to find that COVID-19 posed the greatest threat to those with underlying illness early in the pandemic, with death rates varying by region and certain demographic groups facing higher risk. Early contextualization of public health data is crucial for accurately assessing disease burden and implementing appropriate disease mitigation measures.
Article
Public, Environmental & Occupational Health
Grace T. Patterson, Dennis Manthi, Finnley Osuna, Alfred Muia, Beatrice Olack, Margaret Mbuchi, Omar A. Saldarriaga, Linet Ouma, Mary Inziani, Xiaoying Yu, Phelgona Otieno, Peter C. Melby
Summary: Acute malnutrition affects over 50 million children globally, with unclear mechanisms leading to increased infection risk and poor outcomes. Research identified differences in inflammation and inflammatory responses between children with MAM and healthy controls, potentially influenced by environmental, pathophysiological, and metabolic factors.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Public, Environmental & Occupational Health
Grace E. Patterson, K. Marie McIntyre, Helen E. Clough, Jonathan Rushton
Summary: Throughout history, the impact of pandemics on health, economy, and society has been largely determined by pathogen characteristics and lack of public health resources; while there are similarities in patterns of disease spread and response from historical pandemics, the major risks posed by COVID-19 come from the indirect effects of control measures on health and core societal activities; policymakers should learn from past pandemics to develop appropriate risk assessments and control plans.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Grace T. Patterson, Elvia Y. Osorio, Alex Peniche, Sara M. Dann, Erika Cordova, Geoffrey A. Preidis, Ji Ho Suh, Ichiaki Ito, Omar A. Saldarriaga, Michael Loeffelholz, Nadim J. Ajami, Bruno L. Travi, Peter C. Melby
Summary: Acute malnutrition is associated with abnormal development of the intestinal microbiota and dysfunction of the intestinal barrier, resulting in systemic inflammation and endotoxemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
E. Yaneth Osorio, Zbigniew Gugala, Grace T. Patterson, Genesis Palacios, Erika Cordova, Ashanti Uscanga-Palomeque, Bruno L. Travi, Peter C. Melby
Summary: This study investigates how malnutrition and inflammation affect bone marrow composition and bone health, finding that inflammatory challenges exacerbate bone marrow changes and weaken bone formation in malnourished mice. Inflammatory challenge promotes the differentiation of mesenchymal stem cells towards adipocytes instead of osteoblasts, and increases bone resorption. However, dietary intake of omega-3 fatty acids may reduce inflammation and improve bone health in malnutrition.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rhiannon A. E. Logan, Shannon Quek, Joseph N. Muthoni, Anneliese von Eicken, Laura E. Brettell, Enyia R. Anderson, Marcus E. N. Villena, Shivanand Hegde, Grace T. Patterson, Eva Heinz, Grant L. Hughes, Edward Patterson
Summary: The study confirms the maternal transmission of Cell fusing agent virus (CFAV) and also demonstrates the highly efficient paternal transmission. Horizontal transmission of CFAV was observed, aided by the evaluation of the pupal infection status before mating with an infected individual. This study provides valuable information on the transmission routes of CFAV and suggests the potential use of male or female mosquito releases to control pathogenic arboviruses.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Veterinary Sciences
R. A. Zegpi, S. L. Gulley, V. L. van Santen, K. S. Joiner, H. Toro
Article
Veterinary Sciences
F. Saiada, F. Eldemery, A. R. A. Zegpi, S. L. Gulley, A. Mishra, V. L. van Santen, H. Toro
Article
Veterinary Sciences
R. A. Zegpi, L. He, Q. Yu, K. S. Joiner, V. L. van Santen, H. Toro
Article
Veterinary Sciences
R. A. Zegpi, K. S. Joiner, V. L. van Santen, H. Toro
Article
Veterinary Sciences
Farjana Saiada, Rodrigo A. Gallardo, H. L. Shivaprasad, Charles Corsiglia, Vicky L. van Santen