Article
Clinical Neurology
Fabien Hauw, Guillaume Fargeot, David Adams, Shahram Attarian, Cecile Cauquil, Jean-Baptiste Chanson, Alain Creange, Thierry Gendre, Kumaran Deiva, Emilien Delmont, Bruno Francou, Steeve Genestet, Thierry Kuntzer, Philippe Latour, Gwendal Le Masson, Laurent Magy, Clotilde Nardin, Francois Ochsner, Guilhem Sole, Tanya Stojkovic, Thierry Maisonobe, Celine Tard, Peter van den Berghe, Andoni Echaniz-Laguna
Summary: This study found that 35 out of 1104 patients initially diagnosed with CIDP actually had CMT. The cost of treating these misdiagnosed patients was significantly higher than the cost of performing CMT genetic analysis in the larger patient group, indicating the importance of utilizing CMT genetic investigations before diagnosing CIDP.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Kaien Gu, Carl Boodman, Pamela Orr, Terence Wuerz
Summary: Lyme disease is a tick-borne disease with a wide range of symptoms and challenging diagnosis. This article presents a case of Lyme disease presenting as brachial plexopathy and meningitis.
Review
Public, Environmental & Occupational Health
Sam T. Donta
Summary: The cause of Lyme disease is known, but the etiology of persisting symptoms remains undefined, posing challenges in diagnosis and treatment. Currently, there are no tests available to determine the presence or absence of the infection, complicating the management of Lyme disease.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Allergy
Katelyn H. Wong, Eugene D. Shapiro, Gary K. Soffer
Summary: Lyme disease is caused by the Borrelia burgdorferi sensu lato infection transmitted by ticks, with most patients recovering with antibiotic therapy but some experiencing prolonged non-specific symptoms. Chronic Lyme disease is a broadly defined term for patients with persistent symptoms attributed to a presumed infection, while post-treatment Lyme disease syndrome refers specifically to symptoms persisting after treatment. The relationship between these conditions and the immune system is a topic of increasing relevance in immunology practice.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Klaudia Sowula, Joanna Szaleniec, Mateusz Dworak, Maria Przeklasa, Malgorzata Maraj, Piotr Ceranowicz, Jerzy Tomik
Summary: The study aimed to evaluate the frequency of vertigo symptoms and potential labyrinth damage in patients diagnosed with Lyme disease (LD). Vertigo is often associated with labyrinth and hearing-organ damage in LD patients, and antibiotic therapy is effective in reducing otoneurological symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
John N. Aucott, Ting Yang, Isaac Yoon, Debra Powell, Steven A. Geller, Alison W. Rebman
Summary: Participants with a history of Lyme disease are more likely to meet criteria for post-treatment Lyme disease (PTLD) and report more symptoms compared to those without a history of Lyme disease. Females and individuals with higher exposure to traumatic life events are also at an increased risk of meeting PTLD criteria.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Parasitology
Benoit Talbot, Manisha A. Kulkarni, Robert I. Colautti
Summary: The global emergence of vector-borne and zoonotic diseases is a rapidly growing 'wicked' problem. A transdisciplinary research program grounded in ecological and evolutionary theory and integrating perspectives from the health, social, and natural sciences is needed to address this challenge.
TRENDS IN PARASITOLOGY
(2021)
Review
Infectious Diseases
Richard Horowitz, Phyllis R. Freeman
Summary: Lyme disease and associated co-infections are increasing globally, with a significant proportion of patients developing chronic Lyme disease despite early treatment. High dose pulsed dapsone combination therapy shows promising results in treating resistant Lyme disease and associated co-infections, providing sustained improvement in major symptoms.
Article
Medicine, General & Internal
Gary P. Wormser, Donna McKenna, Tyler Morgan, Carol Scavarda, Denise Cooper, Paul Visintainer
Summary: This study assessed the presence and severity of symptoms in Lyme disease patients with extracutaneous manifestations (ECLD) in the US. There was no significant difference in symptom frequency between ECLD patients and Lyme disease patients with erythema migrans at baseline and 12 months. However, ECLD patients were significantly less likely to be Caucasian, suggesting that erythema migrans skin lesions may have been missed in individuals with darker skin.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Alina Szewczyk-Dabrowska, Wiktoria Budziar, Marek Harhala, Krzysztof Baniecki, Aleksandra Pikies, Natalia Jedruchniewicz, Zuzanna Kazmierczak, Katarzyna Gembara, Tomasz Klimek, Wojciech Witkiewicz, Artur Nahorecki, Kamil Barczyk, Marlena Klak, Urszula Grata-Borkowska, Krystyna Dabrowska
Summary: Predictors for the risk of severe COVID-19 can be identified by testing for antibodies targeting Borrelia, indicating a potential link between tick bites and COVID-19 severity.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Tessalyn Morrison, Sylvia Madaras, Charlotte Larson, Rebecca Harrison
Summary: Women living with controversial diagnoses like chronic Lyme disease face challenges in navigating the medical system to find satisfactory care. They struggle with physical and emotional burdens, disbelief and discrimination from medical providers, and must learn to advocate for themselves to seek affirmative care. By creating communities with each other for mutual aid and support, they are able to cope with the controversial nature of their illness.
QUALITATIVE HEALTH RESEARCH
(2021)
Article
Medicine, General & Internal
Serife Torun, Irem Karaman
Summary: This article presents a case of a patient with RA who was misdiagnosed as COVID-19 twice due to non-specific respiratory symptoms and ground-glass opacities observed in high-resolution CT. The misdiagnosis led to a delayed diagnosis of ILD and prolonged pulmonary symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Shuai Qin, Dongyue Lv, Ran Duan, Xiaojin Zheng, Asaiti Bukai, Xinmin Lu, Qun Duan, Mingrun Yu, Huaiqi Jing, Xin Wang
Summary: Brucellosis is a significant zoonotic disease with non-specific symptoms that are often overlooked and misdiagnosed in clinical practice. This case report highlights a misdiagnosis of brucellosis as COVID-19/influenza during strict COVID-19 control measures, leading to delayed treatment. Neglecting other diseases due to the COVID-19 pandemic and empirical diagnosis and treatment by medical staff contribute to misdiagnosis. Additionally, normal ESR, increased WBC, and increased NEUT also played a role in misdiagnosis, emphasizing the importance of considering brucellosis in patients with fever of unknown origin and related symptoms, especially those from endemic areas. Screening for brucellosis should be prioritized, and healthcare professionals should follow standardized diagnostic criteria based on epidemiological history, clinical manifestations, and laboratory tests.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Sarah A. Hook, Courtney C. Nawrocki, James I. Meek, Katherine A. Feldman, Jennifer L. White, Neeta P. Connally, Alison F. Hinckley
Summary: The study found that human-tick encounters can serve as an accurate proxy for risk of tickborne diseases in areas where these infections are common. Household characteristics associated with tick encounters were similar to individual characteristics, suggesting that human-tick encounters can be a robust proxy for tickborne disease risk in endemic areas.
ZOONOSES AND PUBLIC HEALTH
(2021)
Article
Genetics & Heredity
Sandip De, Sarah. B. B. Kingan, Chrysoula Kitsou, Daniel. M. M. Portik, Shelby. D. D. Foor, Julia. C. C. Frederick, Vipin. S. S. Rana, Nicole. S. S. Paulat, David. A. A. Ray, Yan Wang, Travis. C. C. Glenn, Utpal Pal
Summary: This study presents the assembly of a high-quality genome of Ixodes scapularis by sequencing two haplotypes within one individual. The genome includes new protein-coding genes and various RNA species, providing critical genetic resources and biological insights for tick research and interventions against tick-transmitted infections.
