Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells

Persistent Inflammation Leads to Proliferative Neoplasia and Loss of Smooth Muscle Cells in a Prostate Tumor Model

(2015) Andreas Birbach et al.   NEOPLASIA

Conditionally Ablated Pten in Prostate Basal Cells Promotes Basal-to-Luminal Differentiation and Causes Invasive Prostate Cancer in Mice

(2013) Tsai-Ling Lu et al.   AMERICAN JOURNAL OF PATHOLOGY

PDEF Promotes Luminal Differentiation and Acts as a Survival Factor for ER-Positive Breast Cancer Cells

(2013) Gilles Buchwalter et al.   CANCER CELL

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

(2013) Steven M. Frisch et al.   JOURNAL OF CELL SCIENCE

Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity

(2013) Zhu A. Wang et al.   NATURE CELL BIOLOGY

Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin

(2013) Oh-Joon Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

(2013) T. Stoyanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Adult Murine Prostate Basal and Luminal Cells Are Self-Sustained Lineages that Can Both Serve as Targets for Prostate Cancer Initiation

(2012) Nahyun Choi et al.   CANCER CELL

Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity

(2012) Joseph M. Valdez et al.   Cell Stem Cell

The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration

(2012) Jichao Qin et al.   Cell Stem Cell

Cells of origin for cancer: an updated view from prostate cancer

(2012) L Xin   ONCOGENE

Targeting CreERT2 expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis

(2012) Li Zhang et al.   TRANSGENIC RESEARCH

Repression of Androgen Receptor Activity by HEYL, a Third Member of the Hairy/Enhancer-of-split-related Family of Notch Effectors

(2011) Derek N. Lavery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regenerated Luminal Epithelial Cells Are Derived from Preexisting Luminal Epithelial Cells in Adult Mouse Prostate

(2011) June Liu et al.   MOLECULAR ENDOCRINOLOGY

Purification and direct transformation of epithelial progenitor cells from primary human prostate

(2011) Andrew S Goldstein et al.   Nature Protocols

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling

(2011) Vinagolu K. Rajasekhar et al.   Nature Communications

IAP Regulation of Metastasis

(2010) Swarna Mehrotra et al.   CANCER CELL

The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia

(2010) Lluis Espinosa et al.   CANCER CELL

Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth

(2010) Nayana Ghosh-Choudhury et al.   CELLULAR SIGNALLING

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

(2010) M. Mazzone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin-Sca-1+CD49fhigh Stem/Progenitors Are Tumor-Initiating Cells in the Pten-Null Prostate Cancer Model

(2009) D. J. Mulholland et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells

(2009) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

Identification of Rat Prostatic Secreted Proteins Using Mass Spectrometric Analysis and Androgen-Dependent mRNA Expression

(2009) N. Fujimoto et al.   JOURNAL OF ANDROLOGY

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

(2009) Songcang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

A luminal epithelial stem cell that is a cell of origin for prostate cancer

(2009) Xi Wang et al.   NATURE

Generation of a prostate from a single adult stem cell

(2008) Kevin G. Leong et al.   NATURE

Multiple Oncogenic Pathway Signatures Show Coordinate Expression Patterns in Human Prostate Tumors

(2008) Chad J. Creighton   PLoS One

Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression

(2008) Isis C. Sroka et al.   PROSTATE