Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin

Modular optimization of multi-gene pathways for fatty acids production in E. coli

(2013) Peng Xu et al.   Nature Communications

Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex

(2012) Yuheng Lin et al.   Microbial Cell Factories

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Driving Forces Enable High-Titer Anaerobic 1-Butanol Synthesis in Escherichia coli

(2011) Claire R. Shen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

High-Yield Resveratrol Production in Engineered Escherichia coli

(2011) Chin Giaw Lim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microbial chemical factories: recent advances in pathway engineering for synthesis of value added chemicals

(2011) Himanshu Dhamankar et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Efficient “on water” organocatalytic protocol for the synthesis of optically pure warfarin anticoagulant

(2011) Maria Rogozińska et al.   GREEN CHEMISTRY

Optimization of a heterologous pathway for the production of flavonoids from glucose

(2011) Christine Nicole S. Santos et al.   METABOLIC ENGINEERING

Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways

(2011) Brooks B Bond-Watts et al.   Nature Chemical Biology

Molecular cloning and functional analysis of the ortho-hydroxylases of p-coumaroyl coenzyme A/feruloyl coenzyme A involved in formation of umbelliferone and scopoletin in sweet potato, Ipomoea batatas (L.) Lam.

(2011) Seitaro Matsumoto et al.   PHYTOCHEMISTRY

A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2′-hydroxylase activity (C2′H): a missing step in the synthesis of umbelliferone in plants

(2011) Guilhem Vialart et al.   PLANT JOURNAL

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

A review of new developments in the Friedel–Crafts alkylation – From green chemistry to asymmetric catalysis

(2010) Magnus Rueping et al.   Beilstein Journal of Organic Chemistry

Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring aC-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate

(2010) Jianya Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Clean and Convenient One-Pot Synthesis of 4-Hydroxycoumarin and 4-Hydroxy-2-quinolinone Derivatives

(2010) Wen-Tao Gao et al.   SYNTHETIC COMMUNICATIONS

Structure of PqsD, aPseudomonasQuinolone Signal Biosynthetic Enzyme, in Complex with Anthranilate

(2009) Asim K. Bera et al.   BIOCHEMISTRY

Biochemical Analysis of the Biosynthetic Pathway of an Anticancer Tetracycline SF2575

(2009) Lauren B. Pickens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering

(2009) Wenjuan Zha et al.   METABOLIC ENGINEERING

Automated design of synthetic ribosome binding sites to control protein expression

(2009) Howard M Salis et al.   NATURE BIOTECHNOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

The anticoagulants market

(2009) Irena Melnikova   NATURE REVIEWS DRUG DISCOVERY

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes

(2009) Richard J. Payne et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A novel 4-hydroxycoumarin biosynthetic pathway

(2009) Benye Liu et al.   PLANT MOLECULAR BIOLOGY

PqsD Is Responsible for the Synthesis of 2,4-Dihydroxyquinoline, an Extracellular Metabolite Produced byPseudomonas aeruginosa

(2008) Yong-Mei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinatorial pathway analysis for improved L-tyrosine production in Escherichia coli: Identification of enzymatic bottlenecks by systematic gene overexpression

(2008) Tina Lütke-Eversloh et al.   METABOLIC ENGINEERING

Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene

(2008) Jennifer R. Anthony et al.   METABOLIC ENGINEERING

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

(2008) Shota Atsumi et al.   NATURE

Scopoletin is biosynthesized viaortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase inArabidopsis thaliana

(2008) Kosuke Kai et al.   PLANT JOURNAL

High-yield anthocyanin biosynthesis in engineeredEscherichia coli

(2007) Yajun Yan et al.   BIOTECHNOLOGY AND BIOENGINEERING