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Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Sara A. Al-Shun, Fardous F. El-Senduny, Mohamed A. Ismail, Wael M. El-Sayed, Farid A. Badria, Magdy M. Youssef
Summary: The study investigated different monocationic arylthiophene derivatives as potential chemotherapeutic agents against HCC. Compound 2j showed the highest cytotoxicity among the tested compounds, with a selectivity index indicating safety to normal cells. It was found to inhibit HepG2 cell migration and division, induce apoptosis, and sensitize standard anticancer drugs.
Article
Pharmacology & Pharmacy
Cesar Echeverria, Aldo Martin, Felipe Simon, Cristian O. Salas, Mariajesus Nazal, Diego Varela, Ramon A. Perez-Castro, Juan F. Santibanez, Ricardo O. Valdes-Valdes, Oscar Forero-Doria, Javier Echeverria
Summary: This study evaluated the anticancer effect of tomatine on hepatocellular carcinoma (HCC) in vitro and in vivo models. The results showed that tomatine inhibited HCC tumorigenesis by modulating p53, Ca+2, and ROS signaling pathways, suggesting its potential therapeutic use in HCC patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian
Summary: This study reveals that ZNF498 is highly expressed in hepatocellular carcinoma (HCC) and is associated with advanced pathological grade and poor prognosis. ZNF498 promotes HCC initiation and progression by inhibiting p53 transcriptional activation and phosphorylation. ZNF498 also inhibits p53-mediated apoptosis and ferroptosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Food Science & Technology
Xuening Pang, Xiang Gao, Feng Liu, Yuhuan Jiang, Mingji Wang, Qun Li, Zichao Li
Summary: The study reveals that Xanthoangelol induces caspase-1 mediated pyroptosis and apoptosis in HCC cells, depending on the expression of GSDMD.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Zhili Zeng, Weichi Jiang, Jun Kan, Dong Zhang, Rui Li, Fan He, Yuechen Hu, Xiushen Li, Enxin Zhang, Zebiao Cao
Summary: This study aims to explore the regulatory effect of E2F2 on the p53 signaling pathway and reveal the role and mechanism of STR in promoting cell apoptosis via the E2F2-p53 signaling pathway in HCC. The results showed that E2F2 overexpression significantly inhibited apoptosis and the p53 pathway in HepG2 cells, whereas E2F2-silenced HepG2 cells showed the reverse. STR could remarkably inhibit the growth of xenografts, promote the apoptosis of hepatoma cells, downregulate E2F2, and activate the p53-dependent mitochondrial apoptotic pathway in vivo.
Article
Biochemistry & Molecular Biology
Chao Song, Dongmei Shi, Kaiwen Chang, Xianghui Li, Qing Dong, Xia Ma, Xuefei Wang, Zhenhuan Guo, Yonglu Liu, Jundong Wang
Summary: Fluoride-induced pulmonary toxicity is related to cell apoptosis, with activation of caspase-8 and induction of DR5 playing critical roles. NOX4 and p53 mediate the expression of DR5 induced by NaF, influencing pulmonary apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yomna Mahmoud, Aya M. M. Shehata, Nagui H. Fares, Asmaa A. Mahmoud
Summary: Spirulina has a therapeutic anticarcinogenic effect against advanced hepatocellular carcinoma by improving survival rate, decreasing tumor markers, and suppressing tumor growth. Its mechanisms involve enhancing endogenous antioxidant capacity, promoting apoptosis, and inhibiting oxidative stress and angiogenesis.
Article
Biochemistry & Molecular Biology
Yusha Xiao, Kang Yang, Pengpeng Liu, Dong Ma, Ping Lei, Quanyan Liu
Summary: The study showed that DNASE1L3 could inhibit the progression of HCC by inducing cell apoptosis and weakening glycolysis, suggesting its potential as a prognostic biomarker and therapeutic target for HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Shuo Zhang, Ya-Ning Shi, Jia Gu, Peng He, Qi-Di Ai, Xu-Dong Zhou, Wei Wang, Li Qin
Summary: This study investigates the mechanism of DMY against hepatocellular carcinoma (HCC), revealing that it inhibits the proliferation, migration, and invasion of HCC cells by reducing cholesterol to disrupt lipid rafts.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huibin Xu, Xiaoman Shen, Xiangke Li, Xiaohui Yang, Chuan Chen, Duqiang Luo
Summary: The natural product DSE2, derived from fungi, has potent anticancer activity but its mechanism is unclear. It effectively inhibits gastric cancer cell growth and induces apoptosis by activating PARP-1 and caspase-3. Inhibition or knockdown of PARP-1 or caspase-3 suppresses DSE2-induced apoptosis.
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Santarsiero, Ilaria Pappalardo, Gabriella Margherita Rosa, Isabella Pisano, Stefano Superchi, Paolo Convertini, Simona Todisco, Patrizia Scafato, Vittoria Infantino
Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and a significant cause of cancer-related deaths. In this study, a newly synthesized chalcone ETTC showed cytotoxic activity and induced apoptosis in HCC cells through the activation of the intrinsic pathway of apoptosis and mitochondrial targeting. These findings suggest the potential antitumor effect of ETTC in HCC.
Article
Chemistry, Medicinal
I-Ta Lu, Shih-Chao Lin, Yi-Chia Chu, Ya Wen, You-Cheng Lin, Wen-Chien Cheng, Jyh-Horng Sheu, Chi-Chien Lin
Summary: The compound (-)-Agelasidine A, derived from a sea sponge, has been found to inhibit the viability of human liver cancer cells by activating both mitochondrial apoptosis and endoplasmic reticulum stress-induced apoptosis.
Article
Biochemistry & Molecular Biology
Esraa Tariq Nagy, Abdullah A. S. Ahmed, Elshaymaa I. Elmongy, Saad M. EL-Gendy, Ibrahim Elmadbouh, Ibrahim El Tantawy El Sayed, Mabrouk Attia Abd Eldaim, Ahmed A. El-Gokha
Summary: The cytotoxic activity of 11(4-Aminophenylamino)neocryptolepine (APAN) on HepG2 and HCT-116 carcinoma cell lines was evaluated, and the molecular mechanism through which it exerts its cytotoxic activity was investigated. APAN had highest affinity for protein tyrosine kinase 6 enzyme, and molecular docking studies confirmed its binding affinity scores for relevant proteins. APAN induced cytotoxicity in HepG2 and HCT-116 cells, increased expression of apoptotic proteins, and reduced expression of proliferative proteins.