Journal
ONCOLOGY LETTERS
Volume 9, Issue 3, Pages 1167-1172Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2014.2808
Keywords
chronic lymphocytic leukemia; CD14(+)HLA-DRlow/-; prognostic factor
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Funding
- National Natural Science Foundation [30973568]
- Zhejiang Provincial Natural Science Fund [LH12H16019]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents [2012]
- Zhejiang Provincial Health Bureau [2010KYA015]
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Currently, no prognostic factors exist for determining the host immune status of chronic lymphocytic leukemia (CLL) patients. Therefore, the present report analyzed cluster of differentiation 14 (CD14)(+) human leukocyte antigen (HLA)-DRlow/- myeloid-derived suppressor cells (MDSC) from 49 CLL patients and demonstrated that these cells were significantly expanded in all CLL patients when compared with monoclonal B cell lymphocytosis patients and healthy volunteers. Furthermore, upregulation of CD14(+)HLA-DRlow/- MDSCs was correlated with CLL tumor progression and a poor prognosis for CLL patients, and CD14(+)HLA-DRlow/- MDSCs were significantly correlated with the presence of CD4(+) T and CD5(+)CD19(+) cells in CLL patients, which could significantly inhibit the CD4(+) T-cell immune response, contributing to CLL cell progression in CLL patients.
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