Journal
ONCOLOGY LETTERS
Volume 7, Issue 5, Pages 1738-1742Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2014.1959
Keywords
Lactobacillus delbrueckii; colon cancer; apoptosis; caspase 3; matrix metalloproteinase-9
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Funding
- National Basic Research Program of China (973 project) [2007CB513006]
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Probiotic bacteria are known to exert a wide range of beneficial effects on their animal hosts. Therefore, the present study explored the effect of the supernatants obtained from Lactobacillus delbrueckii fermentation (LBF) on colon cancer. The results indicated that the proliferation of LBF solution-treated colon cancer SW620 cells was arrested and accumulated in the G1 phase in a concentration-dependent manner. The LBF solution efficiently induced apoptosis through the intrinsic caspase 3-depedent pathway, with a corresponding decreased expression of Bcl-2. The activity of matrix metalloproteinase 9, which is associated with the invasion of colon cancer cells, was also decreased in the LBF-treated cells. In conclusion, the results demonstrate the antitumor effect of LBF in vitro and may contribute to the development of novel therapies for the treatment of colon cancer.
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