Article
Oncology
Yunfeng Zhang, Dixin Wang, Linglin Zhang, Long Wen, Haiyan Zhang, Guolong Zhang, Xiuli Wang
Summary: Phakomatosis pigmentovascularis (PPV) is a rare congenital syndrome characterized by capillary malformations and pigmented lesions. In this case report, a pediatric patient with PPV and severe pruritus showed temporary improvement with hematoporphyrin monomethyl ether-mediated photodynamic therapy (HMME-PDT), highlighting the potential efficacy of this treatment modality for PPV patients with refractory pruritus.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Engineering, Biomedical
Peisong Meng, Yi Sun, Enze Li, Yunqing Liu, Cuiping Wang, Liping Song
Summary: The objective of this study was to determine the mechanism and effect of hematoporphyrin monomethyl ether mediated photodynamic therapy (HMME-PDT) on oral squamous cell carcinoma (OSCC). The study found that HMME-PDT can significantly inhibit the growth of OSCC cells, and the mechanism of this effect is related to the regulation of the P53-miR-21-PDCD4 axis via singlet oxygen (O-1(2)) induced by HMME-PDT. These findings provide new insights into the treatment of OSCC.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Chemistry, Physical
Shuang Liu, Mei Wen, Mengmeng Huang, Haifeng Wang, Zhigang Chen, Nuo Yu
Summary: This study presents the synthesis of nanoscale hematoporphrin-based frameworks with Al3+ ions as metal nodes for enhanced photo-sono therapy of malignant tumors. The AlHFs-PEG exhibits high biocompatibility and can produce more 1O2 species than traditional metal-organic frameworks, inhibiting the growth rate of tumors in mice significantly when exposed to both light and ultrasound. This research provides insights for developing nanoscale frameworks with light metal ions as metal nodes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Man-Yi Li, Ying-Hua Gao, Jia -Hui Zhang, Le Mi, Xue-Xue Zhu, Feng Wang, Xing-Ping Zhou, Yi-Jia Yan, Zhi-Long Chen
Summary: A series of novel fluorinated hematoporphyrin ether derivatives were successfully synthesized in this study, among which one compound, II3, showed high phototoxicity, strong effectiveness against lung cancer cells, and promising anti-tumor effects in vivo, making it a potential new drug candidate for photodynamic therapy.
BIOORGANIC CHEMISTRY
(2021)
Article
Dermatology
Xin-yu Zhang, Najwa Al-Odaini, Run-ge Fan, Hong-di Xiong, Jia-can Huang, Hong-mei Dai, Yan-hua Zhou, Xiu-yin Huang, Si-jian Wen
Summary: This study evaluated the clinical efficacy and treatment response of HMME-PDT in adult Chinese patients with port-wine stains (PWSs). The results showed that HMME-PDT is an effective and safe treatment for purple PWSs, and multiple treatments can improve the cure rate.
DERMATOLOGY AND THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Cheng-Chung Chang, Chia-Feng Hsieh, Hsing-Ju Wu, Mohamed Ameen, Tun-Pin Hung
Summary: Sonodynamic therapy (SDT) offers a noninvasive approach for tumor treatment by using ultrasound to activate a sonosensitizer. Two synthesized phenothiazine derivatives showed potential as photosensitizers and sonosensitizers. Among them, compound MB6C exhibited superior therapeutic effects and could be a potential candidate for photodynamic therapy (PDT) and SDT.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Biomedical
Shuxin Liu, Jinjuan Ma, Evelyn Y. Xue, Shaolei Wang, Yubin Zheng, Dennis K. P. Ng, Aiguo Wang, Nan Zheng
Summary: Photodynamic therapy and sonodynamic therapy are highly promising modalities for cancer treatment. A novel nanosensitizer system based on a polymeric phthalocyanine (pPC-TK) is reported, which can self-assemble in water forming nanoparticles with a hydrodynamic diameter of 48 nm. This nanosensitizer exhibits efficient photodynamic and sonodynamic effects, and it can also inhibit tumor growth without causing noticeable side effects. Furthermore, it can retard the growth of a deep-located orthotopic liver tumor in vivo by sonodynamic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Pai Liu, Tianyue Yang, Yaning Li, Jun Guo, Shulan Li, Hongli Chen, Yi Liu
Summary: Sonodynamic therapy (SDT) is a novel therapeutic method with deep penetration, good cell membrane permeability, and the ability to be exposed to light. However, the hypoxic tumor microenvironment and poor targeting of sonosensitizers limit the treatment efficiency of SDT. Therefore, constructing sonosensitizer-based nanoplatforms is crucial for achieving a more comprehensive therapeutic effect.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Nicholas J. Lyons, Rabina Giri, Jakob Begun, David Clark, David Proud, Yaowu He, John D. Hooper, Thomas Kryza
Summary: This article discusses the role of reactive oxygen species (ROS) in normal and malignant colonic cell biology and explores how existing and emerging therapies can utilize ROS for therapeutic benefit. Recent research has shed light on the contribution of ROS to the cytotoxicity of conventional chemotherapy, as well as the generation of ROS in response to excitatory stimuli in emerging therapies such as photodynamic therapy, sonodynamic therapy, and radiodynamic therapy. However, the poor prognosis and resistance associated with metastatic colorectal cancer necessitate the development of new and more effective treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Seong-Yeong Heo, Yeachan Lee, Tae-Hee Kim, Soo-Jin Heo, Hwarang Shin, Jiho Lee, Myunggi Yi, Hyun Wook Kang, Won-Kyo Jung
Summary: Chlorophyllin-assisted photodynamic therapy has shown strong anti-cancer effects on human cervical cancer by inducing apoptosis through oxidative stress. The optimal conditions for photodynamic therapy have been determined, and it regulates the expression of several proteins and suppresses the phosphorylation of AKT1. Overall, chlorophyllin-assisted photodynamic therapy has the potential to be used as an antitumor therapy for cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Wenjing Huang, Binbin Hu, Yalin Yuan, Huaqiang Fang, Junkai Jiang, Qun Li, Yi Zhuo, Xuetao Yang, Jinlu Wei, Xiaolei Wang
Summary: In this study, selenium nanoparticles (SeNPs) were synthesized to enhance antibacterial ability using pure yellow light (YL) source. YL also showed anti-inflammatory and wound healing properties. To overcome the low penetration depth issue in photodynamic therapy (PDT), SeNPs were encapsulated with polyethylenimine (PEI) and modified with indocyanine green (ICG) to achieve combined photoacoustic therapy for promoting healing of drug-resistant bacteria-infected wounds. In vitro and in vivo experiments demonstrated that the antibacterial efficiency of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) exceeded 99% within 10 minutes, effectively killing drug-resistant bacteria and promoting wound repair.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Dermatology
Xu Liu, Lihua Yang, Qian Zhang, Fengjuan Yang, Xian Jiang
Summary: Port-wine birthmarks (PWB) are common congenital vascular malformations that affect the face and neck, with a prevalence of 0.3-0.5% in the general population, causing psychological distress and financial burden. Traditional treatment methods for PWB have been replaced by new therapies, including radioactive nuclide patch therapy. A panel of experts presented 4 clinical cases illustrating the precision and efficacy of Photodynamic therapy (PDT) in the treatment of PWB. After 2-3 sessions of HMME-PDT, significant fading of red skin lesions and noticeable reduction in lesion area were observed in all cases.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wenjian Liu, Jing Su, Qiang Shi, Jinlei Wang, Xiao Chen, Shizhong Zhang, Mengkao Li, Jie Cui, Cundong Fan, Beibei Sun, Guojun Wang
Summary: The study demonstrated that Ag@Se@RGD NPs had stable particle size and morphology in physiological conditions and induced significant integrin-targeted intracellular uptake. In vitro experiments showed that Ag@Se@RGD NPs dose-dependently inhibited U251 human glioma cell growth by inducing cell apoptosis through triggering mitochondrial dysfunction and ROS-dependent MAPKs activation. In vivo administration of Ag@Se@RGD NPs effectively inhibited U251 tumor xenograft growth by inducing apoptosis through regulation of MAPKs activation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia Li, Zheng Hu, Jiwei Zhu, Xin Lin, Xu Gao, Guixiang Lv
Summary: This study developed an improved water-soluble method that significantly enhanced ROS production by destroying the HO-1 antioxidant system, improving the antitumor effects of sonodynamic therapy. It provided a new therapeutic strategy for treating cancers with higher HO-1 expression.
Review
Oncology
Yunjing Hou, Di Zhao, Xinxin Yang, Chenxu Guo, Meina Wen, Junjie Bao, Guofan Qu, Hongxue Meng
Summary: This review comprehensively shows the mechanisms of photodynamic therapy and sonodynamic therapy in the treatment of bone tumors, including promoting immunogenic cell death, influencing signaling pathways, and destroying cellular structures. This combination therapy can effectively eliminate bone tumors and improve postoperative repair.