Article
Oncology
Chengcheng Gong, Qin Xiao, Yi Li, Yajia Gu, Jian Zhang, Leiping Wang, Jun Cao, Zhonghua Tao, Yannan Zhao, Yizhao Xie, Xichun Hu, Biyun Wang
Summary: The study revealed that ERP occurred in more than half of patients with metastatic breast cancer treated with everolimus, and was associated with improved treatment outcomes.
Article
Biochemistry & Molecular Biology
Jiefeng Huang, Jie Li, Jun Tang, Yushen Wu, Fengsheng Dai, Ziying Yi, Yan Wang, Yunhai Li, Yue Wu, Guosheng Ren, Tingxiu Xiang
Summary: This article reveals the important role of ZDHHC22 in breast cancer and its correlation with patient prognosis. ZDHHC22 inhibits the proliferation of breast cancer cells by regulating protein stability and signaling pathway activation. It has the potential to serve as a therapeutic target for endocrine therapy-resistant breast cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Guangxin Li, Jiajia Hu, Christina Cho, Junwei Cui, Ao Li, Pengwei Ren, Jichun Zhou, Wei Wei, Tianxiang Zhang, Xiaoling Liu, Weiru Liu
Summary: Triple-negative breast cancer (TNBC) is a challenging subtype to treat due to lack of targetable receptors. The mTOR signaling pathway has been implicated in TNBC and mTOR inhibition is considered a potential therapeutic strategy. However, the efficacy of mTOR inhibitor everolimus (EVE) in TNBC is still unclear. In this study, we found that EVE monotherapy inhibited mTOR signaling but did not slow tumor progression. Additionally, EVE treatment led to abnormal tumor vasculature and increased PD-L1 expression, resulting in reduced CD8+ T cell infiltration. Combination treatment with anti-PD-1 antibody and EVE normalized tumor vasculature, restored CD8+ T cell infiltration, and reduced tumor growth. Our findings provide insights into mTOR inhibition resistance and propose a novel combination treatment strategy for mTOR resistant TNBC tumors.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Hikmat Abdel-Razeq, Baha' Sharaf, Hazem Abdulelah, Nayef Abdel-Razeq, Mourad Salam, Bayan Inserat, Rayan Bater
Summary: The combination therapy of exemestane and everolimus demonstrates significant efficacy and comparable safety to clinical trials in real-world settings for breast cancer patients.
JOURNAL OF CHEMOTHERAPY
(2022)
Review
Oncology
Huanhuan Huang, Jun Zhou, Hailong Chen, Jiaxin Li, Chao Zhang, Xia Jiang, Chao Ni
Summary: SERMs and SERDs are standard therapies for ER-positive breast cancer, and they also modulate the immune microenvironment. The immune microenvironment plays a crucial role in tumor development, treatment response, and could potentially enhance the effectiveness of immune checkpoint inhibitors in breast cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
M. Schmidt, K. Luebbe, T. Decker, M. Thill, L. Bauer, V Mueller, T. Link, J. Furlanetto, M. Reinisch, C. Mundhenke, O. Hoffmann, M-O Zahn, L. Mueller, C. Denkert, M. van Mackelenbergh, P. A. Fasching, N. Burchardi, V Nekljudova, S. Loibl
Summary: The DESIREE trial showed that a dose-escalation schema of everolimus over 3 weeks can successfully reduce the incidence of high-grade stomatitis in the first 12 weeks of treatment in patients with HR+/HER2- mBC.
Article
Oncology
Eddy S. Yang, Amin H. Nassar, Elio Adib, Opeyemi A. Jegede, Sarah Abou Alaiwi, Deborah L. Della Manna, David A. Braun, Mahsa Zarei, Heng Du, Sumanta K. Pal, Gurudatta Naik, Guru P. Sonpavde
Summary: The study investigated the relationship between gene expression and treatment benefit of Everolimus in metastatic renal cell carcinoma patients. Specific gene signatures were identified that could potentially predict the response to Everolimus monotherapy or combination therapy with a vascular disrupting agent. Further validation of these gene signatures is needed to determine their clinical utility in patient selection.
MOLECULAR CANCER THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Daniela Miricescu, Alexandra Totan, Iulia-Ioana Stanescu-Spinu, Silviu Constantin Badoiu, Constantin Stefani, Maria Greabu
Summary: Breast cancer is a complex disease with various factors contributing to its pathogenesis. Current research is focused on the PI3K/AKT/mTOR signaling pathway and related cancer mutations. Clinical trials are also evaluating the efficacy of inhibitors targeting these signaling pathways in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jill Gluskin, Andrew Plodkowski, Jeffrey Girshman, Debra Sarasohn, Ainhoa Viteri-Jusue, Sumar Hayan, Jean Torrisi
Summary: This study found that mTOR inhibitor-associated pneumonitis often presents with a waxing and waning pattern, which may be accompanied by clinical symptoms. Recognition of this pattern may aid in promoting clinical-radiologic concordance and facilitating patient management.
Article
Oncology
Aditya Bardia, Sara A. Hurvitz, Angela DeMichele, Amy S. Clark, Amelia Zelnak, Denise A. Yardley, Meghan Karuturi, Tara Sanft, Sibel Blau, Lowell Hart, Cynthia Ma, Hope S. Rugo, Das Purkayastha, Stacy Moulder
Summary: Treatment with ribociclib in combination with everolimus and exemestane showed promising efficacy and safety for patients with HR+/HER2(-) ABC after progression on a CDK4/6i, supporting further investigation of CDK4/6 blockade and PI3K/AKT/mTOR pathway targeting in this population.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Alexej Ballhausen, Jennifer J. Wheler, Daniel D. Karp, Sarina A. Piha-Paul, Siqing Fu, Shubham Pant, Apostolia M. Tsimberidou, David S. Hong, Vivek Subbiah, Veronica R. Holley, Helen J. Huang, Abenaa M. Brewster, Kimberly B. Koenig, Nuhad K. Ibrahim, Funda Meric-Bernstam, Filip Janku
Summary: The combination therapy of everolimus, letrozole, and trastuzumab showed favorable safety profile and encouraging signs of anticancer activity in patients with heavily pretreated hormone receptor- and HER2-positive advanced cancers. Some patients, particularly those with HER2 amplification, had partial responses to the treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Camille Moreau-Bachelard, Marie Robert, Carole Gourmelon, Emmanuelle Bourbouloux, Anne Patsouris, Jean-Sebastien Frenel, Mario Campone
Summary: Everolimus is an oral drug that inhibits mTOR with immunosuppressive and antiproliferative characteristics. It is commonly used in association with exemestane in hormone receptor (HR)-positive advanced breast cancer (ABC). This review summarizes the publications relating to everolimus in breast cancer and highlights its efficacy and tolerability, particularly in patients who have previously been treated with aromatase inhibitors (AI).
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Oncology
Alexandra Thomas, Heather A. Parsons, Karen Lisa Smith
Summary: The Oncology Grand Rounds series aims to integrate research reports with clinical practice, helping readers better understand how to apply research findings to patient treatments.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Nicole Mavingire, Petreena Campbell, Jonathan Wooten, Joyce Aja, Melissa B. Davis, Andrea Loaiza-Perez, Eileen Brantley
Summary: Breast cancer stem cells (BCSCs) play a role in promoting endocrine therapy resistance through signaling cascades such as Notch, HIF, and integrin/Akt. Understanding these mechanisms can potentially lead to targeted therapy strategies to counteract endocrine resistance in HR positive breast cancer patients. Additionally, exploring the link between BCSC-regulatory gene levels and reduced survival in African American women with basal-like breast cancer may provide insights for improving clinical outcomes in this population.
Article
Oncology
Mario Campone, Thomas Bachelot, Isabelle Treilleux, Barbara Pistilli, Julia Salleron, Valerie Seegers, Monica Arnedos, Delphine Loussouarn, Qing Wang, Laurence Vanlemmens, Marta Jimenez, Maria Rios, Veronique Dieras, Agnes Leroux, Gilles Paintaud, Keyvan Rezai, Fabrice Andre, Maeva Lion, Jean-Louis Merlin
Summary: Adding everolimus to preoperative trastuzumab did not improve efficacy but induced MAPK signaling in HER2-positive early operable breast cancer patients. Combination therapy should be considered to maximize the effectiveness of trastuzumab in this setting.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Walter Paul Weber, Jane Shaw, Andrea Pusic, Lynda Wyld, Monica Morrow, Tari King, Zoltan Matrai, Joerg Heil, Florian Fitzal, Shelley Potter, Isabel T. Rubio, Maria-Joao Cardoso, Oreste Davide Gentilini, Viviana Galimberti, Virgilio Sacchini, Emiel J. T. Rutgers, John Benson, Tanir M. Allweis, Martin Haug, Regis R. Paulinelli, Tibor Kovacs, Yves Harder, Bahadir M. Gulluoglu, Eduardo Gonzalez, Andree Faridi, Elisabeth Elder, Peter Dubsky, Jens-Uwe Blohmer, Vesna Bjelic-Radisic, Mitchel Barry, Susanne Dieroff Hay, Kimberly Bowles, James French, Roland Reitsamer, Rupert Koller, Peter Schrenk, Daniela Kauer-Dorner, Jorge Biazus, Fabricio Brenelli, Jaime Letzkus, Ramon Saccilotto, Sarianna Joukainen, Susanna Kauhanen, Ulla Karhunen-Enckell, Juergen Hoffmann, Ulrich Kneser, Thorsten Kuhn, Michalis Kontos, Ekaterini Christina Tampaki, Moshe Carmon, Tal Hadar, Giuseppe Catanuto, Carlos A. Garcia-Etienne, Linetta Koppert, Pedro F. Gouveia, Jakob Lagergren, Tor Svensjoe, Nadia Maggi, Elisabeth A. Kappos, Fabienne D. Schwab, Liliana Castrezana, Daniel Steffens, Janna Krol, Christoph Tausch, Andreas Gunthert, Michael Knauer, Maria C. Katapodi, Susanne Bucher, Nik Hauser, Christian Kurzeder, Rosine Mucklow, Pelagia G. Tsoutsou, Atakan Sezer, Guldeniz Karadeniz Cakmak, Hasan Karanlik, Patricia Fairbrother, Laszlo Romics, Giacomo Montagna, Cicero Urban, Melanie Walker, Silvia C. Formenti, Guenther Gruber, Frank Zimmermann, Daniel Rudolf Zwahlen, Sherko Kuemmel, Mahmoud El-Tamer, Marie Jeanne Vrancken Peeters, Orit Kaidar-Person, Michael Gnant, Philip Poortmans, Jana de Boniface
Summary: The aim of this article is to discuss the demand for nipple-and skin-sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) and present clinical practice recommendations in the context of expanded indications for post-mastectomy radiation therapy (PMRT). The panel agrees that surgical technique for NSM/SSM should not be modified when PMRT is planned, with preference for autologous over implant-based BR. However, no specific recommendations are made regarding implant positioning, use of mesh or timing. The use of patient-reported outcomes in clinical practice is endorsed. The article emphasizes the importance of prospective randomized phase III studies and interdisciplinary collaboration for determining optimal sequencing and techniques for PMRT in the context of BR.
Meeting Abstract
Oncology
Carsten Denkert, Frederik Marme, Miguel Martin, Michael Untch, Herve Bonnefoi, Sung-Bae Kim, Harry Bear, Agnieszka Witkiewicz, Seock-Ah Im, Angela DeMichele, Laura Van't Veer, Nicole McCarthy, Thorsten Stiewe, Karen A. Gelmon, Jose A. Garcia-Saenz, Catherine M. Kelly, Toralf Reimer, Erik Knudsen, Nicholas Turner, Federico Rojo, Peter A. Fasching, Julia Teply-Szymanski, Yuan Liu, Masakazu Toi, Hope S. Rugo, Michael Gnant, Andreas Makris, Barbel Felder, Karsten Weber, Sibylle Loibl
Meeting Abstract
Oncology
Karin Rokitte, Kristina Tendl-Schulz, Ulrike Heber, Kerstin Wimmer, Rupert Bartsch, Stephanie Kacerovsky-Strobl, Georg Pfeiler, Gunther G. Steger, Christian F. Singer, Dominik Hlauschek, Michael Gnant, Florian Fitzal, Zsuzsanna Bago-Horvath
Meeting Abstract
Oncology
Michelle Joy Naughton, David Zahrieh, Michael Gnant, Nicholas Zdenkowski, Julie Lemieux, Jun J. Mao, Vesna Bjelic-Radisic, Eileen Shinn, Marija Balic, Christoph Thomssen, Jane Neisel, Manuel Ruiz-Echarri, Sibylle Loibl, Claudine Isaacs, David Cameron, Fernando Manuel Henao Carrasco, Matthew Goetz, Viktor Wette, Gustavo Werutsky, Hope Rugo, Marcus Vetter, Ling-Ming Tseng, Kathy Miller, Florian Fitzal, Juan Miguel Gil Gil, Haeseong Park, Barbro Linderholm, Emilio Bajetta, Zoneddy Dayao, Aleix Prat, Karin Ehrhardt, Otto Metzger, Amal Arahmani, Ernest Law, Ann Partridge, Lisa Carey, Alex Zoroufy, Amylou Dueck, Dominik Hlauschek, Angela DeMichele, Erica Mayer
Meeting Abstract
Oncology
Christoph Minichsdorfer, Thorsten Fuereder, Michael Leutner, Christian F. Singer, Stephanie Kacerovsky-Strobl, Daniel Egle, Richard Greil, Marija Balic, Florian Fitzal, Georg Pfeiler, Sophie Frantal, Rupert A. Bartsch, Michael Gnant
Meeting Abstract
Oncology
Eileen Shinn, David Zahrieh, Angela DeMichele, Nick Zdenkowski, Julie Lemieux, Jun Mao, Vesna Bjelic-Radisic, Michelle Naughton, Georg Pfeiler, Karen Gelmon, Ingrid Mayer, Daniel Egle, Gabriele Zoppoli, Tiffany Traina, Miguel Martin Jimenez, Silvia Antolin Novoa, Tufia Haddad, Arlene Chan, Alistair Edward Ring, Antonio Wolff, Jose JuanPonce Lorenzo, Dhanusha Sabanathan, Hal Burstein, Zbigniew Ireneusz Nowecki, Gunda Pristauz-Telsnigg, Adam Brufsky, Meritxell Bellet-Ezquerra, Theodoros Foukakis, Yelena Novik, Gabor Rubovszky, Karoline Muehlbacher, Otto Metzger, Theodora Goulioti, Ernest Law, Ann Partridge, Lisa Carey, Alex Zoroufy, Dominik Hlauschek, Christian Fesl, Erica Mayer, Michael Gnant
Meeting Abstract
Oncology
Ulrike Heber, Kristina Tendl-Schulz, Stefan Heber, Sabine Danzinger, Rupert Bartsch, Christian F. Singer, Florian Fitzal, Ruth Exner, Michael F. Gnant, Leonhard Mullauer, Zsuzsanna Bago-Horvath
Meeting Abstract
Oncology
Giuseppe Curigliano, Fatima Cardoso, Michael Gnant, Nadia Harbeck, Judy King, Anne-Vibeke Laenkholm, Frederique Penault-Llorca, Aleix Prat
Article
Oncology
Ana-Alicia Beltran-Bless, Mark J. Clemons, Christian Fesl, Richard Greil, Gregory R. Pond, Marija Balic, Lisa Vandermeer, Vesna Bjelic-Radisic, Christian F. Singer, Guenther G. Steger, Ruth Helfgott, Daniel Egle, Lidija Soelkner, Simon P. Gampenrieder, Stephanie Kacerovsky-Strobl, Christoph Suppan, Magdalena Ritter, Gabriel Rinnerthaler, Georg Pfeiler, Hannes Fohler, Dominik Hlauschek, John Hilton, Michael Gnant
Summary: The impact of early treatment cessation on adjuvant bisphosphonate therapy for postmenopausal early breast cancer patients was evaluated. The study found that the number of bisphosphonate infusions had no significant association with breast cancer-specific outcomes. Further research is needed to define optimal regimens of adjuvant bone-targeted therapies.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Frankie A. Holmes, Beverly Moy, Suzette Delaloge, Stephen K. L. Chia, Bent Ejlertsen, Janine Mansi, Hiroji Iwata, Michael Gnant, Marc Buyse, Carlos H. Barrios, Tajana Silovski, Robert Separovic, Anna Bashford, Angel Guerrero Zotano, Neelima Denduluri, Debra Patt, Erhan Gokmen, Ira Gore, John W. Smith Ii, Sibylle Loibl, Norikazu Masuda, Zorica Tomasevic, Katarina Petrakova, Daniel DiPrimeo, Alvin Wong, Miguel Martin, Arlene Chan
Summary: ExteNET study showed that neratinib significantly improved invasive disease-free survival in women with early-stage HER2-positive breast cancer compared to placebo after 1 year of treatment with trastuzumab-based therapy. The final analysis revealed that overall survival rates were comparable between neratinib and placebo in the extended adjuvant setting.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Giuseppe Curigliano, Fatima Cardoso, Michael Gnant, Nadia Harbeck, Judy King, Anne-Vibeke Laenkholm, Frederique Penault-Llorca, Aleix Prat
Summary: Breast cancer multigene signatures (BCMS) have changed the management of early-stage breast cancer (eBC) by providing prognostic information and helping select patients for adjuvant chemotherapy. However, there is limited knowledge on the current usage and perceived utility of BCMS in clinical practice. A two-round Delphi survey involving 133 breast cancer experts from 11 European countries revealed that BCMS are widely used to assess risk of recurrence and select patients for adjuvant chemotherapy, but consensus is lacking regarding their utility in selecting specific chemotherapy types. There are also discrepancies between recommended usage and actual usage, with some profiles lacking supporting evidence. The study suggests the need for physician education initiatives to ensure proper use and interpretation of BCMS, ultimately improving management of eBC patients.
Article
Oncology
Michael Gnant, Christian F. Singer, Gabriel Rinnerthaler, Georg Pfeiler, Daniel Egle, Marija Balic, Rupert Bartsch
Summary: Inhibitors of CDK4/6 have become the standard of care in advanced hormone-receptor-positive, HER2-negative breast cancer, and are now being evaluated as a targeted therapy for early breast cancer. However, the results of clinical trials in this setting are controversial. This position paper provides a summary of the evidence and guidance for clinical practice.
MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Ana-Alicia Beltran-Bless, Stephanie Kacerovsky-Strobl, Michael Gnant
Summary: Treatment for early-stage breast cancer is complex, with many options available. Patient physician conversations need to effectively communicate the risks and benefits of different treatments in a personalized and understandable way. Breast conserving therapy with radiation is often the recommended treatment, but research is ongoing to determine the optimal patient populations for reduced lymph node sampling and omission of radiation.
Review
Oncology
Marija Balic, Christoph Thomssen, Michael Gnant, Nadia Harbeck
Summary: The St. Gallen Consensus Conference on early breast cancer treatment in 2023 was successfully held in Vienna, Austria, with more than 2,800 participants from over 100 countries attending. The conference focused on important topics such as radiotherapy and local management, genetics and their impact on treatment, and the role of the immune system and tumor-infiltrating lymphocytes in the pathological reports and treatment decision-making.
Meeting Abstract
Oncology
Georg Pfeiler, Dominik Hlauschek, Erica L. Mayer, Christine Deutschmann, Stephanie Kacerovsky-Strobl, Miguel Martin, Jane Lowe Meisel, Nicholas Zdenkowski, Sibylle Loibl, Marija Balic, Haeseong Park, Aleix Prat, Claudine Isaacs, Jana Machacek-Link, Celine Schurmans, Kathy Puyana Theall, Christian Fesl, Amylou C. Dueck, Angela DeMichele, Michael Gnant
JOURNAL OF CLINICAL ONCOLOGY
(2022)