Impact of Molecular Biology Studies on the Understanding of Brain Tumors in Childhood

Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

(2011) Huriye Cin et al.   ACTA NEUROPATHOLOGICA

Nonsense Mutation and Inactivation of SMARCA4 (BRG1) in an Atypical Teratoid/Rhabdoid Tumor Showing Retained SMARCB1 (INI1) Expression

(2011) Martin Hasselblatt et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Histology predicts a favorable outcome in young children with desmoplastic medulloblastoma

(2011) Sarah E.S. Leary et al.   CANCER

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma

(2011) M. Monje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes

(2010) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Germline Nonsense Mutation and Somatic Inactivation of SMARCA4/BRG1 in a Family with Rhabdoid Tumor Predisposition Syndrome

(2010) Reinhard Schneppenheim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MGMT promoter methylation in pediatric high-grade gliomas

(2010) Matteo Fassan et al.   CHILDS NERVOUS SYSTEM

Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor α and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets

(2010) Maryam Zarghooni et al.   JOURNAL OF CLINICAL ONCOLOGY

Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis

(2010) Stefan Rutkowski et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

(2010) Barbara S. Paugh et al.   JOURNAL OF CLINICAL ONCOLOGY

TP53 Mutation Is Frequently Associated With CTNNB1 Mutation or MYCN Amplification and Is Compatible With Long-Term Survival in Medulloblastoma

(2010) Elke Pfaff et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas

(2010) Manila Antonelli et al.   JOURNAL OF NEURO-ONCOLOGY

Subtypes of medulloblastoma have distinct developmental origins

(2010) Paul Gibson et al.   NATURE

Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas

(2010) Jennifer Barrow et al.   NEURO-ONCOLOGY

Long-Term Effects of Radiation Exposure among Adult Survivors of Childhood Cancer: Results from the Childhood Cancer Survivor Study

(2010) Gregory T. Armstrong et al.   RADIATION RESEARCH

Embryonal Tumors With Abundant Neuropil and True Rosettes

(2009) Marco Gessi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Duplication of 7q34 in Pediatric Low-Grade Astrocytomas Detected by High-Density Single-Nucleotide Polymorphism-Based Genotype Arrays Results in a NovelBRAFFusion Gene

(2009) Angela J. Sievert et al.   BRAIN PATHOLOGY

Claudin 6 Is a Positive Marker for Atypical Teratoid/Rhabdoid Tumors

(2009) Diane K. Birks et al.   BRAIN PATHOLOGY

EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines

(2009) D. A. Bax et al.   CLINICAL CANCER RESEARCH

Late Effects of Therapy for Pediatric Brain Tumor Survivors

(2009) Christopher D. Turner et al.   JOURNAL OF CHILD NEUROLOGY

Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and theMYCandMYCNLoci

(2009) Stefan Pfister et al.   JOURNAL OF CLINICAL ONCOLOGY

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Medulloblastoma associated with novel PTCH mutation as primary manifestation of Gorlin syndrome

(2009) J. R. Crawford et al.   NEUROLOGY

Large cell/anaplastic medulloblastoma: Outcome according to myc status, histopathological, and clinical risk factors

(2009) Katja von Hoff et al.   PEDIATRIC BLOOD & CANCER

Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes

(2008) Stefan Pfister et al.   ACTA NEUROPATHOLOGICA

Protein Expression of Platelet-Derived Growth Factor Receptor Correlates with Malignant Histology and PTEN with Survival in Childhood Gliomas

(2008) H. K. Thorarinsdottir et al.   CLINICAL CANCER RESEARCH

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

(2008) Stefan Pfister et al.   JOURNAL OF CLINICAL INVESTIGATION

Tyrosine kinase expression in pediatric high grade astrocytoma

(2008) Muh-Lii Liang et al.   JOURNAL OF NEURO-ONCOLOGY

Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective

(2008) Judith M. de Bont et al.   NEURO-ONCOLOGY

Identification of interleukin-13 receptor α2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma

(2008) Bharat H. Joshi et al.   NEURO-ONCOLOGY

Gender affects survival for medulloblastoma only in older children and adults: A study from the surveillance epidemiology and end results registry

(2008) Emily K. Curran et al.   PEDIATRIC BLOOD & CANCER

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One