Journal
EPIGENOMICS
Volume 11, Issue 1, Pages 5-21Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2018-0080
Keywords
breast cancer; DNA methylation; microfibrillar-associated protein 4; overall survival; TCGA
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Funding
- National Natural Science Foundation of China [81700169]
- Natural Science Foundation of Guizhou Province [201842920480710623]
- 'Light of the West' Talent Cultivation Program of the Chinese Academy of Sciences [201684]
- Found for Guizhou Fourth Batch of '100 Talented Leaders'
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Aim: The potential functions and underlying mechanism of microfibrillar-associated proteins (MFAPs) are explored in human cancers. Materials & methods: Here, we examined the expression profiles, prognostic values, epigenetic and genetic alterations of MFAPs in human cancers from public omics repository. Results: Among MFAPs family, MFAP4 was frequently downregulated in the most human cancers and high mRNA expression of MFAP4 significantly correlated with better overall survival in breast cancer. DNA hypermethylation in the promoter of MFAP4 decreased its mRNA expression. MFAP4 strongly associated with pathway in impairment and alteration of the elastic fibers. Conclusion: This integrated analysis provides new insights into MFAPs in human cancers and indicates that MFAP4 could be used as novel biomarker for developing therapies against human cancers.
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