Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Review
Cell Biology
Shihang Zhou, Hongliang Zeng, Jinhua Huang, Li Lei, Xiaoliang Tong, Si Li, Ying Zhou, Haoran Guo, Manal Khan, Liping Luo, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Melanogenesis is a complex process involving multiple genes and signaling pathways, with epigenetics playing a key role in regulating the expression of key genes. Epigenetic-based therapy provides novel opportunities for treating dermatoses caused by pigmentation disturbances.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Julian Aldana, Miranda L. L. Gardner, Michael A. A. Freitas
Summary: A comprehensive multi-omics approach was used to study the effects of differential H3K27me3 deposition driven by EZH2 mutations. The study identified pathways involved in cellular proliferation, differentiation, and migration that are impacted by EZH2 GOF and LOF mutants. The results shed light on EZH2-mediated cell transformative processes from the epigenetic to the phenotypic level, providing insights for improved diagnostics and treatment in hematologic malignancies with mutated EZH2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Vasiliki Zolota, Vasiliki Tzelepi, Zoi Piperigkou, Helen Kourea, Efthymia Papakonstantinou, Maria-Ioanna Argentou, Nikos K. Karamanos
Summary: Current data suggest that epigenetic alterations play a key role in the initiation and subclonal evolution of breast cancer, especially in the aggressive molecular subgroup of triple-negative breast cancer. The extracellular matrix undergoes significant structural alterations during cancer progression, which are closely linked with epigenetic modifiers. Targeting tumor microenvironment and epigenetic pathways may provide potential therapeutic strategies, particularly in triple-negative breast cancer where standard chemotherapy is limited.
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Sui, Wenliang Qiao, Xinrong Xiang, Youfu Luo
Summary: This article describes the epigenetic changes that occur in the pathogen Mycobacterium tuberculosis and its host during infection, including DNA methylation, histone modification, and microRNA. It summarizes the research progress in drug discovery and tuberculosis diagnosis, providing new ideas and strategies to combat drug-resistant tuberculosis.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Luke Twenhafel, DiAnna Moreno, Trista Punt, Madeline Kinney, Rebecca Ryznar
Summary: Osteosarcoma is a common malignant bone tumor in children and adolescents. Despite improvements in clinical outcomes, early detection is crucial for better survival rates and reducing the need for debilitating treatments like amputations. Research in the field of epigenetics, focusing on changes in genetic expression above the genome, shows potential for understanding and improving the treatment of osteosarcoma.
Review
Environmental Sciences
Kim Pham, Long Ho, Claudio Peter D'Incal, Andree De Cock, Wim Vanden Berghe, Peter Goethals
Summary: Environmental epigenetics has become a key research focus in climate change and environmental pollutant investigations in aquatic ecosystems. DNA methylation is the most robust epigenetic regulatory mark studied in aquatic animals, while histone variants and ncRNA regulation are less popular. Next generation sequencing and mass spectrometry-based methods offer opportunities for large-scale epigenetic studies in the future.
ENVIRONMENTAL POLLUTION
(2023)
Review
Oncology
Richard Sean Lee, Kirti Sad, Dorelle V. Fawwal, Jennifer Marie Spangle
Summary: Breast cancer is a frequent and deadly disease in women, with histone-modifying enzymes playing a role in treatment response and patient outcomes. Epigenetic changes to chromatin affect the tumor environment and can be targeted for breast cancer treatment. Understanding these mechanisms may improve therapeutic interventions and patient outcomes.
Review
Biochemistry & Molecular Biology
Dominik Franciszek Dluski, Ewa Wolinska, Maciej Skrzypczak
Summary: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that appears or is diagnosed for the first time during pregnancy. Studies have shown that GDM can impact both pregnancy and offspring development, leading to long-term adverse health outcomes. Epigenetic changes such as histone modification, DNA methylation, and altered ncRNA function, including miRNAs, play a role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Stefano Zoroddu, Irene Marchesi, Luigi Bagella
Summary: Muscle differentiation failure may involve epigenetic systems and the PRC2 complex. Research has shown that EZH2 is often deregulated in rhabdomyosarcoma and is associated with tumor malignancy.
CLINICAL EPIGENETICS
(2021)
Review
Cell Biology
Xiaomin Ma, Xin Wang, Guangbing Zheng, Guiqin Tan, Fangyu Zhou, Wenwen Wei, Dan Tian, Hongsong Yu
Summary: Behçet's disease is a chronic multisystem autoimmune disease with complex pathogenesis involving genetics, environmental factors, and gut microbiota. Previous studies have indicated that external environmental factors and abnormalities in epigenetic modification may impact the development of BD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Gaelle Judes, Khaldoun Rifai, Marine Daures, Lucas Dubois, Yves Jean Bignon, Frederique Penault-Llorca, Dominique Bernard-Gallon
Letter
Biotechnology & Applied Microbiology
Marine Daures, Marjolaine Ngollo, Gaelle Judes, Khaldoun Rifai, Jean-Louis Kemeny, Frederique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2016)
Letter
Biotechnology & Applied Microbiology
Gaelle Judes, Aslihan Dagdemir, Seher Karsli-Ceppioglu, Andre Lebert, Marie-Melanie Dauplat, Khaldoun Rifai, Marine Daures, Lucas Dubois, Yves-Jean Bignon, Frederique Penault-Llorca, Dominique Bernard-Gallon
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2016)
Article
Genetics & Heredity
Gaelle Judes, Aslihan Dagdemir, Seher Karsli-Ceppioglu, Andre Lebert, Maureen Echegut, Marjolaine Ngollo, Yves-Jean Bignon, Frederique Penault-Llorca, Dominique Bernard-Gallon
Article
Oncology
Khaldoun Rifai, Gaelle Judes, Mouhamed Idrissou, Marine Daures, Yves-Jean Bignon, Frederique Penault-Llorca, Dominique Bernard-Gallon
Article
Multidisciplinary Sciences
Seher Karsli-Ceppioglu, Aslihan Dagdemir, Gaelle Judes, Andre Lebert, Frederique Penault-Llorca, Yves-Jean Bignon, Dominique Bernard-Gallon
SCIENTIFIC REPORTS
(2017)
Article
Genetics & Heredity
Gaelle Judes, Lucas Dubois, Khaldoun Rifai, Mouhamed Idrissou, Florence Mishellany, Amaury Pajon, Sophie Besse, Marine Daures, Fracoise Degoul, Yves-Jean Bignon, Frederique Penault-Llorca, Dominique Bernard-Gallon
Review
Oncology
Khaldoun Rifai, Mouhamed Idrissou, Frederique Penault-Llorca, Yves-Jean Bignon, Dominique Bernard-Gallon
Letter
Biotechnology & Applied Microbiology
Mouhamed Idrissou, Gaelle Judes, Marine Daures, Anna Sanchez, Driss El Ouardi, Sophie Besse, Francoise Degoul, Frederique Penault-Llorca, Yves-Jean Bignon, Dominique Bernard-Gallon
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2019)
Letter
Biotechnology & Applied Microbiology
Mouhamed Idrissou, Khaldoun Rifai, Marine Daures, Frederique Penault-Llorca, Yves-Jean Bignon, Dominique Bernard-Gallon
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2018)
Letter
Biotechnology & Applied Microbiology
Khaldoun Rifai, Mouhamed Idrissou, Marine Daures, Yves-Jean Bignon, Frederique Penault-Llorca, Dominique Bernard-Gallon
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2018)
Letter
Biotechnology & Applied Microbiology
Gaelle Judes, Lucas Dubois, Khaldoun Rifai, Marine Daures, Mouhamed Idrissou, Yves-Jean Bignon, Frederique Penault-Llorca, Dominique Bernard-Gallon
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2017)
Letter
Biotechnology & Applied Microbiology
Mouhamed Idrissou, Marine Daures, Amani Ben Jemia, Gaelle Judes, Khaldoun Rifai, Frederique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2017)
Article
Oncology
Marjolaine Ngollo, Andre Lebert, Marine Daures, Gaelle Judes, Khaldoun Rifai, Lucas Dubois, Jean-Louis Kemeny, Frederique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon
Article
Oncology
Aslihan Dagdemir, Gaelle Judes, Andre Lebert, Maureen Echegut, Seher Karsli-Ceppioglu, Khaldoun Rifai, Marine Daures, Marjolaine Ngollo, Lucas Dubois, Frederique Penault-Llorca, Yves-Jean Bignon, Dominique Bernard-Gallon
CANCER GENOMICS & PROTEOMICS
(2016)
