Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

(2013) Metin Karahoca et al.   Clinical Epigenetics

Specific inhibition of one DNMT1-including complex influences tumor initiation and progression

(2013) Mathilde Cheray et al.   Clinical Epigenetics

DNA methylation inhibitors in cancer: Recent and future approaches

(2012) Christina Gros et al.   BIOCHIMIE

Inhibitors of DNA Methyltransferases: Insights from Computational Studies

(2012) J. Yoo et al.   CURRENT MEDICINAL CHEMISTRY

DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies

(2012) Jacques Fahy et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

(2012) T. Clouaire et al.   GENES & DEVELOPMENT

Advances in the computational development of DNA methyltransferase inhibitors

(2011) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

(2011) Max Felle et al.   NUCLEIC ACIDS RESEARCH

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

(2010) Weihua Qin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation

(2010) Giovanni L Gravina et al.   Molecular Cancer

Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach

(2010) Jose L. Medina-Franco et al.   MOLECULAR DIVERSITY

Disruption of Dnmt1/PCNA/UHRF1 Interactions Promotes Tumorigenesis from Human and Mice Glial Cells

(2010) Eric Hervouet et al.   PLoS One

Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation

(2009) Dirk Kuck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors

(2009) Takayoshi Suzuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small Molecule Inhibitors of the p53-MDM2

(2008) Chun-Qi Hu et al.   CURRENT MEDICINAL CHEMISTRY

CFP1 Interacts with DNMT1 Independently of Association with the Setd1 Histone H3K4 Methyltransferase Complexes

(2008) Jill Sergesketter Butler et al.   DNA AND CELL BIOLOGY