Article
Chemistry, Multidisciplinary
Ana L. Graca, Manuel Gomez-Florit, Hugo Osorio, Marcia T. Rodrigues, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Summary: This study produced and characterized platelet-derived EVs and investigated their effects on different cell types. The EVs were found to regulate stem cell differentiation, promote angiogenesis, and modulate macrophage polarization, suggesting their potential as therapeutic tools in tissue engineering and regenerative medicine.
Article
Biochemistry & Molecular Biology
Susan Y. S. Li, Rebecca Johnson, Leon C. D. Smyth, Mike Dragunow
Summary: This review provides an updated overview of the actions of platelet-derived growth factors on neurovascular function, their role in regulating perivascular cell types, and their clinical relevance and therapeutic potential for neurological diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Engineering, Biomedical
Harsha Kabra, Tanaya Walimbe, Kate Stuart, Camille Indey, Swati Jalgaonkar, Elvis Ikwa, Taylor Skurnac, Julia Chen, Andrew Woolley, Nicholas M. Snead, Nathan Bachtell, Diana J. Leeming, Morten Karsdal, Glenn Prestwich, Alyssa Panitch, John Paderi
Summary: SBR-294, targeting collagen-mediated platelet activation and PDGF activity, showed potential therapeutic benefits in reducing liver fibrosis in the CCl4 mouse model. Further investigation is warranted to explore its potential as a treatment for liver fibrosis.
Article
Multidisciplinary Sciences
Wenhai Cao, Xiaotong Meng, Fangming Cao, Jinpeng Wang, Maowei Yang
Summary: Diabetic non-healing wounds pose a significant burden on patients and society. Platelet-rich plasma (PRP) has been widely used for tissue regeneration and PRP-derived exosomes (PRP-Exos) have shown to be more effective in tissue regeneration. This study investigated the therapeutic potential of PRP-Exos in diabetic wound healing and found that they can promote fibroblast functions and accelerate wound healing through a specific signaling pathway.
Article
Geriatrics & Gerontology
Yu Cai, Zhengchao Wang, Bokai Liao, Zhenxing Sun, Pengfei Zhu
Summary: This article explores the effects of platelet-derived growth factor (PDGF)-BB on osteoarthritis (OA) and finds that PDGF-BB can attenuate OA development by inhibiting inflammation and enhancing cell proliferation through various signaling pathways. This is the first study to report the role of PDGF-BB in regulating OA development via PKA-mediated regulation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ju Tian, Xiong Jie Li, Yongshi Ma, Zhiming Mai, Yao Yang, Min Luo, Wenping Xu, Kui Chen, Xuri Chen, Jianbing Tang, Biao Cheng, Xiao Cui
Summary: This study compared the concentrations of bioactive components in platelet-rich plasma (PRP) derived from umbilical cord blood (UCB) and healthy female adults. UCB-derived PRP contained various active ingredients and showed potential as a research direction for anti-ageing therapy.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Weidong Wu, Shuaijun Jia, Hailiang Xu, Ziheng Gao, Zhiyuan Wang, Botao Lu, Yixiang Ai, Youjun Liu, Renfeng Liu, Tong Yang, Rongjin Luo, Chunping Hu, Lingbo Kong, Dageng Huang, Liang Yan, Zhimou Yang, Lei Zhu, Dingjun Hao
Summary: A strategy of using PDGF-MP hydrogel microspheres instead of bulk hydrogels can enhance the efficiency of PDGF-MP in activating its receptor, thus improving the therapeutic ability of neural stem cells (NSCs) in treating spinal cord injuries (SCI). In vitro experiments showed that PDGF-MP hydrogel microspheres maintained the proliferation and inhibited the apoptosis of NSCs in the presence of myelin extracts. In vivo experiments demonstrated that PDGF-MP hydrogel microspheres inhibited inflammatory cell infiltration and cell apoptosis, and promoted axonal regeneration, synapse formation, and angiogenesis in SCI rats.
Article
Chemistry, Multidisciplinary
Jason Fang, Laura E. Turner, Michelle C. Y. Chang
Summary: Fluorine is a critical element in designing bioactive compounds, but the synthesis of stereogenic tertiary fluorides is challenging and limited to a few approved drugs. In this study, the aldol reaction of fluorinated donors catalyzed by HpcH and engineered variants was found to generate enantiopure secondary and tertiary fluorides. This method not only represents the first synthesis of tertiary fluorides via biocatalysis but also increases the diversity of fluorinated building blocks and enables the synthesis of fluorinated drug analogs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Ting-An Yie, Cynthia A. Loomis, Johannes Nowatzky, Alireza Khodadadi-Jamayran, Ziyan Lin, Michael Cammer, Clea Barnett, Valeria Mezzano, Mark Alu, Jackson A. Novick, John S. Munger, Matthias C. Kugler
Summary: Normal lung development relies on the coordinated action of HH and PDGF signaling pathways, which are crucial for mesenchymal differentiation and proliferation. Recent studies have shown that HH is necessary for alveolar myofibroblast differentiation. In this study, we investigated the relationship between HH and PDGF signaling during postnatal lung development in mice. Our findings suggest that HH and PDGF signaling pathways intersect to support myofibroblast function during secondary alveolar septum formation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Flavia A. Graca, Anna Stephan, Benjamin A. Minden-Birkenmaier, Abbas Shirinifard, Yong-Dong Wang, Fabio Demontis, Myriam Labelle
Summary: Skeletal muscle regeneration requires coordinated interactions between different cell types. Platelet-rich plasma has been widely used as an aid for muscle repair, but the specific role of platelets in regeneration remains unknown. This study shows that platelet-released chemokines play a crucial role in muscle repair by recruiting neutrophils to injured muscles in mice. The depletion of platelets reduces the levels of neutrophil chemoattractants, resulting in impaired neutrophil infiltration and compromised muscle regeneration.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Julia Vidan-Estevez, Sergio Sanchez-Herraez, Fernando Escalante-Barrigon, Jesus Seco-Calvo
Summary: The study on treating chronic non-healing wounds with al-PRP showed that treatment duration significantly influenced wound healing, with the best results seen in cases where treatment extended beyond 13 weeks.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Article
Neurosciences
Jelena Medved, William M. Wood, Michael D. van Heyst, Amin Sherafat, Ju-Young Song, Sagune Sakya, Dennis L. Wright, Akiko Nishiyama
Summary: Oligodendrocyte precursor cells play a crucial role in brain development and have the potential to be targeted for the treatment of brain tumors.
Article
Cardiac & Cardiovascular Systems
Ai Yaku, Tadakatsu Inagaki, Ryotaro Asano, Makoto Okazawa, Hiroyoshi Mori, Ayuko Sato, Fabian Hia, Takeshi Masaki, Yusuke Manabe, Tomohiko Ishibashi, Alexis Vandenbon, Yoshinari Nakatsuka, Kotaro Akaki, Masanori Yoshinaga, Takuya Uehata, Takashi Mino, Satoshi Morita, Hatsue Ishibashi-Ueda, Akio Morinobu, Tohru Tsujimura, Takeshi Ogo, Yoshikazu Nakaoka, Osamu Takeuchi
Summary: The study found that Regnase-1 maintains lung immune homeostasis by regulating IL-6 and platelet-derived growth factor in alveolar macrophages, suppressing the development of PAH. Mice lacking Regnase-1 showed severe PAH, mirroring the pathology of patients. IL-6 and PDGF are potential targets of Regnase-1 in regulating PAH in alveolar macrophages.
Article
Biochemistry & Molecular Biology
Krzysztof Gomulka, Ewa Wojcik, Jacek Cezary Szepietowski
Summary: Atopic dermatitis is a chronic, highly pruritic, relapsing-remitting inflammatory skin disease. This study found that the serum levels of EDN and VEGF were significantly increased in patients with AD, while the level of PAF showed no significant difference. In AD patients, there was a positive correlation between the EDN level and the severity of the disease.