Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 2, Issue 2, Pages 148-153Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml100220b
Keywords
Progesterone; progesterone receptor; NR3C3; progesterone receptor antagonist; uterine fibroids; Suzuki cross-coupling reaction
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We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other steroid nuclear hormone receptors such as the mineralocorticoid receptor (MR). They were prepared from 2-bromo-6-nitro indole in four to six steps using a Suzuki Cross-coupling as the key step. Compound 8f was orally active in the complement 3 model of progesterone antagonism in the rat uterus and demonstrated partial antagonism in the McPhail model of progesterone activity.
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