Deciphering the complexities of human diseases and disorders by coupling induced-pluripotent stem cells and systems genetics

Genetic modifiers of cancer risk for BRCA1 and BRCA2 mutation carriers

(2011) R. L. Milne et al.   ANNALS OF ONCOLOGY

A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models

(2011) Peter Langfelder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PCL2 modulates gene regulatory networks controlling self-renewal and commitment in embryonic stem cells

(2011) Emily Walker et al.   CELL CYCLE

New perspectives in stem cell research: beyond embryonic stem cells

(2011) C. Leeb et al.   CELL PROLIFERATION

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

(2011) Louise C. Laurent et al.   Cell Stem Cell

Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs

(2011) Norikatsu Miyoshi et al.   Cell Stem Cell

Network for Activation of Human Endothelial Cells by Oxidized Phospholipids

(2011) Casey E. Romanoski et al.   CIRCULATION RESEARCH

The Use of Induced Pluripotent Stem Cells in Drug Development

(2011) H Inoue et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes

(2011) Swarkar Sharma et al.   HUMAN MOLECULAR GENETICS

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

(2011) Aaron Y.L. Cheung et al.   HUMAN MOLECULAR GENETICS

Stem Cells for Drug Screening

(2011) Rebecca R Laposa   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Copy number variation and selection during reprogramming to pluripotency

(2011) Samer M. Hussein et al.   NATURE

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

Genetic engineering of human pluripotent cells using TALE nucleases

(2011) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

A bioinformatic assay for pluripotency in human cells

(2011) Franz-Josef Müller et al.   NATURE METHODS

Induced pluripotent stem cells for modelling human diseases

(2011) J. J. Unternaehrer et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells

(2011) Jessica Dias et al.   STEM CELLS AND DEVELOPMENT

Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine

(2011) Jonghwan Kim et al.   Genome Medicine

DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time

(2011) Koichiro Nishino et al.   PLoS Genetics

Mouse Genome-Wide Association and Systems Genetics Identify Asxl2 As a Regulator of Bone Mineral Density and Osteoclastogenesis

(2011) Charles R. Farber et al.   PLoS Genetics

Genome-wide approaches to schizophrenia

(2010) Jubao Duan et al.   BRAIN RESEARCH BULLETIN

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

(2010) Saiyong Zhu et al.   Cell Stem Cell

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

(2010) Yoav Mayshar et al.   Cell Stem Cell

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells

(2010) R. David Hawkins et al.   Cell Stem Cell

Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation

(2010) Emily Walker et al.   Cell Stem Cell

Reprogramming of T Cells from Human Peripheral Blood

(2010) Yuin-Han Loh et al.   Cell Stem Cell

Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells

(2010) Judith Staerk et al.   Cell Stem Cell

Generation of Induced Pluripotent Stem Cells from Human Terminally Differentiated Circulating T Cells

(2010) Tomohisa Seki et al.   Cell Stem Cell

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Cardiovascular Networks

(2010) Aldons J. Lusis et al.   CIRCULATION

Gene-delivery systems for iPS cell generation

(2010) Lijian Shao et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1

(2010) M. J. Edel et al.   GENES & DEVELOPMENT

Genome-wide Association Studies of Cancer Predisposition

(2010) Zsofia K. Stadler et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Genetics of neurodegenerative diseases: insights from high-throughput resequencing

(2010) S. Tsuji   HUMAN MOLECULAR GENETICS

Derivation, culture, and characterization of VUB hESC lines

(2010) Ileana Mateizel et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

(2010) Xonia Carvajal-Vergara et al.   NATURE

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

(2010) Na-Yu Chia et al.   NATURE

Epigenetic memory in induced pluripotent stem cells

(2010) K. Kim et al.   NATURE

Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes

(2010) Stormy J. Chamberlain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence

(2010) Qiang Feng et al.   STEM CELLS

Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer

(2010) Antonella Galvan et al.   TRENDS IN GENETICS

Inhibition of Tgf-β Signaling Improves Mouse Fibroblast Reprogramming

(2009) Knut Woltjen et al.   Cell Stem Cell

Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease

(2009) Krishanu Saha et al.   Cell Stem Cell

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

(2009) Yoshinori Yoshida et al.   Cell Stem Cell

A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

(2009) Justin K. Ichida et al.   Cell Stem Cell

Alternative Induced Pluripotent Stem Cell Characterization Criteria for In Vitro Applications

(2009) James Ellis et al.   Cell Stem Cell

Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells

(2009) Jizhong Zou et al.   Cell Stem Cell

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology

Stem cells: Fast and furious

(2009) Monya Baker   NATURE

Systems-level dynamic analyses of fate change in murine embryonic stem cells

(2009) Rong Lu et al.   NATURE

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

A chemical platform for improved induction of human iPSCs

(2009) Tongxiang Lin et al.   NATURE METHODS

Systems genetics analysis of cancer susceptibility: from mouse models to humans

(2009) David Quigley et al.   NATURE REVIEWS GENETICS

Systems biology of stem cell fate and cellular reprogramming

(2009) Ben D. MacArthur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding cardiovascular disease through the lens of genome-wide association studies

(2009) Dan E. Arking et al.   TRENDS IN GENETICS

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

A chemical approach to stem-cell biology and regenerative medicine

(2008) Yue Xu et al.   NATURE

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Generation of human induced pluripotent stem cells from dermal fibroblasts

(2008) W. E. Lowry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA