Journal
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
Volume 2, Issue 1, Pages 117-125Publisher
WILEY
DOI: 10.1002/wsbm.21
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Funding
- Dan L. Duncan Cancer Center (Baylor College of Medicine)
- Caroline Wiess Law Fund for Molecular Medicine
- L. E. and Josephine S. Gordy Memorial Cancer Research Fund
- NATIONAL CANCER INSTITUTE [R01CA138628] Funding Source: NIH RePORTER
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Bidirectional signaling between the oocyte and surrounding somatic cells is absolutely essential for successful germ cell development in mammals. Oocytes secrete proteins that are necessary for granulosa cells growth and differentiation, whilst granulosa cells regulate oocyte development and integrate ovarian function with the rest of the body by orchestrating gonadal steroidogenesis. The importance of communication between the oocyte and granulosa cells is highlighted by genetic deletion of members of the transforming growth factor beta (TGF beta) family and their downstream signaling components. Such knockout models have uncovered an interesting spectrum of reproductive phenotypes that have greatly advanced our knowledge of ovarian function and dysfunction. The current review focuses on some of the more recent transgenic mouse models that elucidate the intraovarian TGF beta signaling vital for oocyte and granulosa cell development. (C) 2009 John Wiley & Sons, Inc. WIREs Syst Biol Med 2010 2 117-125
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