Article
Oncology
Guangxin Li, Bin Shu, Zhuozhao Zheng, Hongfang Yin, Chen Zhang, Ying Xiao, Yanmei Yang, Zhe Yan, Xiaofei Zhang, Shizhong Yang, Gong Li, Jiahong Dong
Summary: This study explores the combination of lenvatinib and sintilimab with radiotherapy as a neoadjuvant treatment regimen for hepatocellular carcinoma with portal vein tumor thrombus. The results of this study will be significant in increasing the surgical resection rate and improving the overall survival of patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiu-Ping Zhang, Bozhao Li, Zefang Lu, Ming-Gen Hu, Guo-Dong Zhao, Shuai Xu, Zhouliang Wu, Tianjiao Chu, Feilong Qi, Suying Wu, Guangjun Nie, Suping Li, Rong Liu
Summary: In this study, an acid-responsive polymeric nanocarrier was developed to deliver anticoagulant and chemotherapeutic drugs into portal vein tumor thrombus (PVTT) for effective inhibition of hepatocellular carcinoma (HCC). The nanocarrier allowed continuous accumulation of the drugs at a constant ratio in the PVTT, leading to potent anti-tumor efficacy without side effects in mouse models. This work highlights the importance of PVTT modulation in advanced HCC treatment and presents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion.
Article
Oncology
Yuan Tian, Wenbiao Jin, Honghua Sun, Dehao Jin, Dongxu Kang, Zhiyu Li, Longzhen Piao
Summary: mHAIC combined with lenvatinib and camrelizumab is a safe and effective treatment option for huge HCC or PVTT, improving patient compliance.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Oncology
Jun Jia, Jing Sun, Xuezhang Duan, Wengang Li
Summary: The study found that CP scores are closely related to the development of RILD in HCC patients, and pretreatment CP scores and RILD are significantly associated with overall survival. SBRT is an effective and safe method for patients with CP <= B7, while patients with CP-B8 should have their liver function monitored more frequently. SBRT treatment is not safe enough for patients with CP-B9.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qinghe Tang, Wei Huang, Jun Liang, Junli Xue
Summary: In elderly patients with advanced HCC and PVTT, TACE treatment was associated with better overall survival and progression-free survival, especially for patients with type I and type II PVTT. TACE could significantly prolong PFS and improve OS compared to best supportive care, making it an effective measure for this population.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zili Hu, Zhenyun Yang, Jiongliang Wang, Yizhen Fu, Zhiwen Hu, Zhongguo Zhou, Minshan Chen, Yaojun Zhang
Summary: This study suggests that neoadjuvant hepatic arterial infusion chemotherapy followed by hepatectomy is associated with longer survival outcome compared to hepatectomy alone for hepatocellular carcinoma patients with portal vein tumor thrombus. The survival benefit is limited to patients who respond to neoadjuvant FOLFOX-HAIC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Zhenli Li, Mingda Zhao, Xingshun Qi, Yufu Tang, Shuqun Cheng
Summary: Hepatocellular carcinoma (HCC) is a common and aggressive malignancy, and portal vein tumour thrombus (PVTT) is a serious complication associated with poor prognosis. Recent studies have implicated tumor microenvironment, stem cells, abnormal gene expression, and non-coding RNA deregulation in PVTT formation and development. However, the precise molecular mechanisms of PVTT in HCC patients remain largely unknown. In this review, we provide a brief summary of the molecular mechanisms underlying PVTT in HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Guang Sheng Zhao, Song Liu, Ying Liu, Chuang Li, Ruo Yu Wang, Jie Bian, Yue Wei Zhang, Jun Zhou, Ya Jie Lin, Jianlin Wu
Summary: This study aimed to investigate the clinical efficacy and prognostic factors of Gelfoam for drug-eluting bead transarterial chemoembolization (GMD-TACE) in patients with unresectable large hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). The results showed that GMD-TACE can be used as a core treatment for improving the quality of life and extending the median overall survival (OS) in these patients. The type of tumor thrombus and combination therapy were identified as important factors affecting prognosis.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Pathology
Wei-Xing Guo, Shi-Ye Yang, Lei Guo, Jin-Kai Feng, Jie Xue, Jie Shi, Wan Yee Lau, Dong Yu, Shu-Qun Cheng
Summary: PVTT-HCC is a rare type of HCC with poor survival outcomes. RNA-Seq analysis revealed differential gene expression between PVTT-HCC and HCC-PVTT, suggesting distinct biological characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Hao Sun, Bing Ma, Ning Sun, Han Bai, Xuejian Li, Chengshuo Zhang
Summary: This study compared the oncological prognosis of different perioperative locoregional adjuvant treatments for HCC with PVTT. The results showed that adjuvant therapy with radiotherapy had the lowest hazard ratio for both overall survival (OS) and recurrence-free survival (RFS). It was concluded that perioperative locoregional adjuvant therapy, especially radiotherapy, provides survival benefits and reduces the risk of recurrence for HCC patients with PVTT.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chun- Wang, Pei-Ming Chu, Yi-Li Chen, Yang-Hsiang Lin, Cheng-Yi Chen
Summary: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide, often associated with inflammation and drug resistance post-chemotherapy. Understanding the role of cytokines in HCC pathogenesis can help overcome inflammatory reactions and cytokine secretion, ultimately counteracting chemotherapeutic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Wan Yee Lau, Kang Wang, Xiu-Ping Zhang, Le-Qun Li, Tian-Fu Wen, Min-Shan Chen, Wei-Dong Jia, Li Xu, Jie Shi, Wei-Xing Guo, Ju-Xian Sun, Zhen-Hua Chen, Lei Guo, Xu-Biao Wei, Chong-De Lu, Jie Xue, Li-Ping Zhou, Ya-Xing Zheng, Meng Wang, Meng-Chao Wu, Shu-Qun Cheng
Summary: A new staging system for hepatocellular carcinoma (HCC) associated with portal vein tumor thrombus (PVTT) was developed, incorporating various factors and showing good discriminatory ability to separate patients into different stages and substages.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Oncology
Weijie Zhou, Da Lang Fang, Yongfei He
Summary: This study revealed that immune-related genes may play a role in the formation of portal vein tumor thrombus (PVTT) and are associated with the prognosis of patients with hepatocellular carcinoma (HCC). A model was constructed to predict patient prognosis and identify different risk categories.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Review
Oncology
Jianchen Luo, Liangliang Xu, Lian Li, Jingfu Zhang, Ming Zhang, Mingqing Xu
Summary: This study analyzed the survival benefit of different treatment options for PVTT patients, with sorafenib + TACE being the most effective treatment option followed by hepatectomy alone.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Zong-Tao Chai, Xiu-Ping Zhang, Min Shao, Jian-Yang Ao, Zhen-Hua Chen, Fan Zhang, Yi-Ren Hu, Cheng-Qian Zhong, Jian-Hua Lin, Kun-Peng Fang, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
Summary: Splenomegaly is an independent risk factor for poor long-term survival in HCC patients with PVTT, while splenectomy can significantly improve the long-term survival of these patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yoshihiro Sakano, Takehiro Noda, Shogo Kobayashi, Akihiro Kitagawa, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Kunihito Gotoh, Tadafumi Asaoka, Masahiro Tanemura, Koji Umeshita, Koshi Mimori, Yuichiro Doki, Hidetoshi Eguchi
Summary: High ACYP1 expression could affect the prognosis of cHCC-iCCA, HCC, and iCCA patients. In vitro, ACYP1 expression influences tumor growth and cell viability in both HCC and iCCA by regulating anti-apoptosis proteins.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Keisuke Toya, Yoshito Tomimaru, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the healing time and potential factors associated with the healing time of postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). The study found that the neutrophil-to-lymphocyte ratio was the only factor independently associated with the healing time of POPF. Patients with a lower neutrophil-to-lymphocyte ratio had significantly shorter healing times for POPF after DP.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2022)
Article
Oncology
Suguru Mitsufuji, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study found that CLU inhibition leads to cellular senescence in PDAC. Our findings suggest that CLU is a novel therapeutic target that contributes to the prognosis of PDAC by inducing cellular senescence.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Suguru Mitsufuji, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Suguru Mitsufuji, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Kazuya Kato, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Takehiro Noda, Hidenori Takahashi, Masahiro Tanemura, Hiroki Kiyokawa, Shinichiro Tahara, Eiichi Morii, Yuichiro Doki, Hidetoshi Eguchi
Summary: Colorectal liver metastasis (CRLM) with bile duct tumor thrombus (BDTT) is a rare condition often diagnosed after surgical resection. We report a case of a 79 year-old woman with CRLM associated with BDTT. This case highlights the importance of considering CRLM with BDTT and surgical treatment in patients with a history of colorectal cancer presenting with BDTT.
INTERNATIONAL CANCER CONFERENCE JOURNAL
(2023)
Editorial Material
Oncology
Takeshi Kado, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Takeshi Kado, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study demonstrates that GDA involvement is an independent factor significantly associated with postoperative survival in PDAC. Patients with GDA contact > 180 degrees have a poorer prognosis, which may be linked to the development of postoperative distant metastasis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the impact of changes in body composition on postoperative outcomes in patients with PDAC undergoing neoadjuvant chemoradiotherapy. The results showed that loss of skeletal muscle mass during NACRT was an independent risk factor for survival in PDAC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Takeshi Kado, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yoshito Tomimaru, Hidetoshi Eguchi, Yosuke Inoue, Yuichi Nagakawa, Akihiro Ohba, Hideki Takami, Michiaki Unno, Tomohisa Yamamoto, Shoji Kawakatsu, Tsuyoshi Hayashi, Ryota Higuchi, Hirohisa Kitagawa, Satoshi Hattori, Tsutomu Fujii, Yoshiki Hirooka, Hisato Igarashi, Masayuki Kitano, Tamotsu Kuroki, Atsushi Masamune, Yasuhiro Shimizu, Masaji Tani, Satoshi Tanno, Yoshihisa Tsuji, Hiroki Yamaue, Sohei Satoi, Yoshifumi Takeyama
Summary: Based on a study by the Japan Adjuvant Study Group, the standard adjuvant chemotherapy duration for pancreatic ductal adenocarcinoma (PDAC) is 6 months. This study aimed to investigate the impact of extending the duration of S-1 chemotherapy on postoperative survival in PDAC patients using real-world data.
Article
Oncology
Daiki Marukawa, Kunihito Gotoh, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study found that high expression of Rubicon is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy. In addition, downregulation of Rubicon can improve invasion ability and cell viability in gemcitabine-resistant pancreatic ductal adenocarcinoma.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hiroki Imamura, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
Summary: After pancreatojejunostomy for pancreatic head resection, contrast-enhanced computed tomography may reveal a hypoattenuated area at the pancreatojejunostomy site. The clinical significance of this hypoattenuated area in terms of postoperative pancreatic fistula is still unknown.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)