Article
Nursing
Ya Su, Mitsuko Asamoto, Michiko Yuki, Masaru Saito, Naoko Hasebe, Kengo Hirayama, Mika Otsuki, Chieko Iino
Summary: The study found that acute phase post-stroke fatigue (PSF) was an independent predictor of PSF after discharge home. 17% of survivors experienced persistent PSF post-discharge, which was significantly associated with depression, insomnia, sarcopenia, and lower quality of life scores.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Clinical Neurology
Nereida Bueno-Guerra, Marta Provencio, Aida Tarifa-Rodriguez, Ana Navarro, Cristian Sempere-Iborra, Pablo Jordi, Elena de Celis-Ruiz, Maria Alonso de Lecinana, Marta Martin-Alonso, Ricardo Rigual, Gerardo Ruiz-Ares, Jorge Rodriguez-Pardo, Javier Virues-Ortega, Blanca Fuentes
Summary: Post-stroke aphasia is associated with reduced quality of life and higher risk of depression. This study aims to evaluate the impact of post-stroke aphasia on self-reported quality of life and symptoms of depression.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Cristina Canova, Isabella Rosato, Ilaria Marsilio, Flavio Valiante, Valerio Zorzetto, Giovanni Cataudella, Anna D'Odorico, Fabiana Zingone
Summary: The study found that the quality of life, anxiety, and depression scores of CeD patients improved significantly within the first year after diagnosis, but the improvements after 1 and 2 years were not significant. Improvement patterns were similar between classical and nonclassical CeD patients, except for anxiety which improved only in classical patients with presentation at diagnosis.
Article
Clinical Neurology
Inge Kirchberger, Florian Wallner, Jakob Linseisen, Philipp Zickler, Michael Ertl, Markus Naumann, Christine Meisinger
Summary: This study found that post-stroke fatigue is a common symptom, even in patients with mild impairment, and can persist over time. Prior depressive disorder and early depressive symptoms were identified as the most relevant predictors of both early and late fatigue.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Xiao-Wei Fan, Yang Yang, Shuo Wang, Yi-Jun Zhang, An-Xin Wang, Xiao-Ling Liao, Wei-Guo Ma, Ning Zhang, Chun-Xue Wang, Yong-Jun Wang
Summary: The impact of baseline and persistent poor sleep quality on short-term poststroke anxiety and depression was investigated in this study. The results showed that patients with persistent poor sleep quality are at increased risks for depression and anxiety after stroke.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Medicine, General & Internal
Kelly White, Samuel Tate, Ross Zafonte, Shrikanth Narayanan, Matthias R. Mehl, Min Shin, Amar Dhand
Summary: Social isolation is a significant risk factor for health outcomes, and a machine learning algorithm called SocialBit has been created to detect social interaction time based on vocal features. This study aims to validate the accuracy of SocialBit in stroke survivors with varying deficits and examine the association of social interaction time with stroke characteristics and outcomes.
Article
Psychology, Multidisciplinary
Amy Waller, Kristy Fakes, Mariko Carey, Joshua Dizon, Kim Parrey, Michelle Coad, Rob Sanson-Fisher
Summary: This study aimed to explore the self-reported outcomes of stroke survivors and identify sociodemographic and disease characteristics that contribute to these outcomes. The findings revealed that certain sub-groups of stroke survivors experience poorer quality of life and psychological morbidity in the early post-discharge phase, highlighting the importance of early identification and prioritization of at-risk individuals for tailored discharge processes.
Article
Psychiatry
Meijing Hu, Baiyang Zhang, Yidie Lin, Minghan Xu, Cairong Zhu
Summary: This study investigated the trajectories of physical and mental quality of life (QoL) during the first six months after ischemic stroke, and found associations between these trajectories and long-term prognosis. The results showed that improving patients' QoL was associated with better long-term survival.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Clinical Neurology
Nora-Elena Wadle, Christina Schwab, Carola Seifart, Felix von Podewils, Susanne Knake, Laurent M. Willems, Katja Menzler, Juliane Schulz, Nadine Conradi, Felix Rosenow, Adam Strzelczyk
Summary: Despite increased awareness of SUDEP, a substantial population of PWE remain poorly informed. Providing SUDEP information does not have adverse effects on health, HRQoL, depressive symptoms, stigma, or seizure worry among PWE, who appreciate receiving information.
Article
Medicine, General & Internal
Adam Zalewski, Piotr K. Krajewski, Jacek C. Szepietowski
Summary: Hand eczema has a significant psychological burden on patients, impacting their quality of life and potentially leading to depression and anxiety disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Yi Wang, Shilpa Tyagi, Helen Hoenig, Kim En Lee, Narayanaswamy Venketasubramanian, Edward Menon, Deidre Anne De Silva, Philip Yap, Boon Yeow Tan, Sherry H. Young, Yee Sien Ng, Tian Ming Tu, Yan Hoon Ang, Keng He Kong, Rajinder Singh, Reshma A. Merchant, Hui Meng Chang, Chou Ning, Angela Cheong, Gerald Choon-Huat Koh
Summary: Informal care burden remains high up to 12-months post-stroke, with factors such as functional dependency, stroke severity, informal caregiver gender, and co-caring with foreign domestic workers being associated with informal care burden.
Article
Health Care Sciences & Services
Minyoung Shin, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Young-Hoon Lee, Won Hyuk Chang, Seyoung Shin, Soo Mi Choi, Seon Kui Lee, Yun-Hee Kim
Summary: This study investigated the impact of post-stroke depression (PSD) on cognitive aging in elderly stroke patients. The results showed that early PSD increased the risk of cognitive decline in older stroke patients, mainly in males. Older male patients with negative thinking were at increased risk of cognitive decline, and older women may also be at risk for cognitive decline.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dermatology
Iben Frier Ruge, Sunna Thorsteinsdottir, Sarah Norgaard, Bo L. Chawes, Klaus Bonnelykke, Jakob Stokholm, Hans Bisgaard
Summary: The study found that many patients with chronic skin diseases experience pruritus, which negatively impacts their daily lives. Patients with moderate to severe pruritus had significantly impaired sleep quality and work productivity compared to those with mild or no pruritus, and they were also more prone to depression and anxiety.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Clinical Neurology
Ju Yeon Seo, Ji Won Yeom, Chul-Hyun Cho, Serhim Son, Yong-Min Ahn, Se Joo Kim, Tae Hyon Ha, Boseok Cha, Eunsoo Moon, Dong Yeon Park, Ji Hyun Baek, Hee-Ju Kang, Hyonggin An, Heon-Jeong Lee
Summary: The study found that morningness is associated with depressive symptoms and quality of life. Individuals with morningness have milder depressive symptoms and better quality of life.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Kimford J. Meador, Zachary N. Stowe, Carrie Brown, Chelsea P. Robalino, Abigail G. Matthews, Laura A. Kalayjian, P. Emanuela Voinescu, Elizabeth E. Gerard, Patricia Penovich, Evan R. Gedzelman, Jennifer Cavitt, Page B. Pennell
Summary: The study found that while there was no difference in the incidence of MDE among pregnant women with epilepsy during pregnancy and postpartum compared to the control groups, they experienced more severe depressive and anxiety symptoms. Factors associated with MDE included seizure frequency, anticonvulsant polytherapy, unplanned pregnancy, and history of mood disorder.
Article
Psychiatry
Ole Kohler-Forsberg, Louisa G. Sylvia, Michael Thase, Joseph R. Calabrese, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, Dan Iosifescu, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Vicki Fung, Michael J. Ostacher, Andrew A. Nierenberg
Summary: This study found that patients with bipolar disorder who used lithium in combination with antipsychotics or anticonvulsants showed worse response compared to those who only used lithium. However, compared to lithium and anticonvulsants, the combined use of lithium and antipsychotics showed slight improvement in general and manic symptoms, but worse development in glucose, triglycerides, and metabolic syndrome.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Goi Khia Eng, Katherine A. Collins, Carina Brown, Molly Ludlow, Russell H. Tobe, Dan Iosifescu, Emily R. Stern
Summary: Patients with OCD exhibit abnormality in their internal sensation perception and altered functioning of the insula, and these differences are associated with the connectivity of the insula. The study found that OCD patients showed a three-component solution in their interoceptive sensibility, compared to the two-component solution in controls. Furthermore, the study identified specific network connections in the insula that could be targeted for modulation of interoceptive sensibility in OCD.
Article
Clinical Neurology
Katherine A. Collins, Goi Khia Eng, Umit Tural, Molly K. Irvin, Dan Iosifescu, Emily R. Stern
Summary: This study used a large dataset to explore the heterogeneity of depression symptoms and identified different symptom subsets and patient groups. By comparing the response to citalopram in different groups, it was found that somatic symptoms and core affective symptoms had different impacts on treatment. This highlights the importance of assessing a wide range of symptoms and the need for treatments specifically targeting physical symptoms in exploring the heterogeneity of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Maya Kuperberg, Ole Kohler-Forsberg, Alec P. Shannon, Nevita George, Sophie Greenebaum, Charles L. Bowden, Joseph R. Calabrese, Michael Thase, Richard C. Shelton, Melvin McInnis, Thilo Deckersbach, Mauricio Tohen, James H. Kocsis, Terence A. Ketter, Edward S. Friedman, Dan Iosifescu, Michael J. Ostacher, Louisa G. Sylvia, Susan L. McElroy, Andrew A. Nierenberg
Summary: The study found that patients with bipolar disorder have an increased cardiometabolic risk associated with symptom severity, and treatment with quetiapine can worsen cardiometabolic markers. The results highlight the importance of monitoring cardiometabolic risks during treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychology, Clinical
Umit Tural, Dan Iosifescu
Summary: Adiponectin levels are higher in overall AN and specifically in the binge-eating/purging and the restrictive AN subtypes. Insulin, IGF-1, BMI, triglyceride, resistin, glucose, and IL-6 levels are significant modifiers of adiponectin levels.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2022)
Review
Multidisciplinary Sciences
Franciele Cordeiro Gabriel, Airton Tetelbom Stein, Daniela de Oliveira Melo, Gessica Caroline Henrique Fontes-Mota, Itamires Benicio dos Santos, Camila da Silva Rodrigues, Andrea D. Dourado, Monica Cristiane Rodrigues, Renerio Fraguas, Ivan Florez, Diogo Telles Correia, Eliane Ribeiro
Summary: Depression is a serious mental health disorder, and some patients with depression fail to respond to antidepressant treatment, known as treatment-resistant depression (TRD). Clinical practice guidelines (CPGs) aim to improve diagnosis and treatment, but there is significant variability in the definitions and recommendations for TRD among high-quality CPGs.
Review
Clinical Neurology
Zamfira Parincu, Dan V. Iosifescu
Summary: Major depressive disorder is a leading cause of disability globally. Current pharmacotherapies targeting monoamine receptors are often ineffective and slow-acting, highlighting a need for more rapid and effective treatments. Studies have shown that combining dextromethorphan with quinidine or bupropion can effectively reduce depressive symptoms in MDD, but results are mixed for TRD and bipolar depression, warranting further research.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Letter
Psychiatry
Matthew J. Hoptman, Umit Tural, Molly S. Arnold, Katherine A. Collins, Kathryn T. Evans, Molly K. Irvin, Zamfira Parincu, Danielle N. Rette, Allison M. Sparpana, Elizabeth F. Sullivan, Dan V. Iosifescu
SCHIZOPHRENIA RESEARCH
(2023)
Review
Medicine, General & Internal
Franciele Cordeiro Gabriel, Daniela Oliveira de Melo, Airton Tetelbom Stein, Gessica Caroline Henrique Fontes-Mota, Itamires Benicio dos Santos, Camila da Silva Rodrigues, Monica Cristiane Rodrigues, Tatiane Bomfim Ribeiro, Renerio Fraguas, Ivan D. Florez, Diogo Telles-Correia, Eliane Ribeiro
Summary: This study aimed to assess the quality of clinical practice guidelines for the pharmacological treatment of depression and explore factors associated with higher quality. The results showed that 27% of the guidelines were classified as high quality, with 11.1% having high-quality recommendations. Factors associated with higher quality included handling of conflicts of interest, multiprofessional teams, and type of institution.
Review
Biology
Umit Tural, Allison Sparpana, Elizabeth Sullivan, Dan V. Iosifescu
Summary: This study conducted a network meta-analysis to investigate the differences in adiponectin levels across eating disorders, obesity, constitutional thinness, and healthy controls. The results showed that participants with anorexia nervosa had significantly higher adiponectin levels, while obesity and binge-eating disorder were associated with significantly lower levels. These findings suggest that adiponectin may be an important marker of metabolic imbalance.
Article
Psychiatry
Willians Fernando Vieira, Dan Iosifescu, Kayla Marie McEachern, Maia Gersten, Paolo Cassano
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2023)
Article
Health Care Sciences & Services
Dan V. Iosifescu, Xiaotong Song, Maia B. Gersten, Arwa Adib, Yoonju Cho, Katherine M. Collins, Kathy F. Yates, Aura M. Hurtado-Puerto, Kayla M. McEachern, Ricardo S. Osorio, Paolo Cassano
Summary: This study aims to investigate the impact, safety, and mechanisms of transcranial photobiomodulation (t-PBM) on cognition in patients with amnestic mild cognitive impairment (aMCI) and early Alzheimer's disease (AD). The participants will receive 24 sessions of t-PBM treatment over 8 weeks, and the study will explore whether baseline tau burden and changes in mitochondrial function moderate the cognitive changes observed after t-PBM therapy. Additionally, changes in the fMRI blood-oxygenation-level-dependent (BOLD) signal after a single treatment will be examined to demonstrate t-PBM-dependent increases in prefrontal cortex blood flow.
Article
Medicine, General & Internal
Carolina Bortolozzo Graciolli Facanali, Carlos Walter Sobrado Junior, Renerio Fraguas Junior, Marcio Roberto Facanali Junior, Lucas Rodrigues Boarini, Lucas Faraco Sobrado, Ivan Cecconello
Summary: This study aims to assess the prevalence of major depressive disorder (MDD) in patients with Crohn's disease (CD) and examine the relationship between MDD and CD outcomes. The findings showed a high prevalence of MDD in CD patients and suggested a potential association between MDD and CD activity.
Article
Psychiatry
Russell H. Tobe, Lucia Tu, John R. Keefe, Melissa M. Breland, Benjamin A. Ely, Melissa Sital, Jasmin T. Richard, Umit Tural, Dan V. Iosifescu, Vilma Gabbay
Summary: This study aims to examine the factors influencing the expression of anhedonia. By evaluating physical, developmental, and clinical measures, the study found a correlation between personality traits and anhedonia, while diagnostic and symptom measures were not significant predictors of anhedonia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Meeting Abstract
Neurosciences
Akila Weerasekera, Eva Ratai, Jacek Dmochowski, Katherine A. Collins, Aura M. Hurtado, Luis De Taboada, Maia B. Gersten, Julie A. Clancy, Matthew J. Hoptman, Molly K. Irvin, Allison Sparpana, Elizabeth Sullivan, Xiaotong Song, Arwa Adib, Paolo Cassano, Dan V. Iosifescu
NEUROPSYCHOPHARMACOLOGY
(2022)
