Virtual Screening as a Technique for PPAR Modulator Discovery

Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists

(2009) Hao Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

(2008) Agustin Casimiro-Garcia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural and Biochemical Basis for the Binding Selectivity of Peroxisome Proliferator-activated Receptor γ to PGC-1α

(2008) Yong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Communication between the ERRα Homodimer Interface and the PGC-1α Binding Surface via the Helix 8–9 Loop

(2008) Holger Greschik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

(2008) Roberta Montanari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Insight into PPARγ Activation Through Covalent Modification with Endogenous Fatty Acids

(2008) Tsuyoshi Waku et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Structural basis for the activation of PPARγ by oxidized fatty acids

(2008) Toshimasa Itoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular recognition of nitrated fatty acids by PPARγ

(2008) Yong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

(2008) D. R. Artis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Botanical drugs: Challenges and opportunities

(2007) Yixuan Liu et al.   LIFE SCIENCES