Review
Biochemistry & Molecular Biology
Vladimir V. Sobolev, Ekaterina Tchepourina, Irina M. Korsunskaya, Natalia A. Geppe, Svetlana N. Chebysheva, Anna G. Soboleva, Alexandre Mezentsev
Summary: This review discusses the role of PPAR-gamma in the pathogenesis of psoriasis and evaluates the potential of PPAR-gamma agonists as therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Aleksandra Kurzynska, Zuzanna Kunicka, Karol Mierzejewski, Monika Golubska, Iwona Bogacka
Summary: This study aimed to investigate the effects of PPAR ligands on the synthesis of nuclear receptor kappa B and selected cytokines in the pig myometrium. The results showed that different PPAR ligands had varying effects on the transcript and protein abundances of different cytokines, mainly observed in tissues from pregnant animals.
ANIMAL REPRODUCTION SCIENCE
(2021)
Review
Oncology
Douglas C. Chung, Nicolas Jacquelot, Maryam Ghaedi, Kathrin Warner, Pamela S. Ohashi
Summary: This review highlights the immunosuppressive roles of innate lymphoid cells (ILCs) in cancer. ILCs inhibit anti-tumour immune response through various mechanisms and impact tumour progression. The review also discusses the history and challenges in defining immunosuppressive ILCs.
Review
Immunology
Daniel Toobian, Pradipta Ghosh, Gajanan D. Katkar
Summary: This review article focuses on the potential roles of peroxisome proliferator-activated receptors (PPARs) in macrophage biology, as well as the modulation of immune cell function, microbial infection, and inflammatory diseases by dual and pan PPAR agonists.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Vu N. Bach, Jane Ding, Miranda Yeung, Taylor Conrad, Hussain N. Odeh, Paige Cubberly, Christopher Figy, Han-Fei Ding, Robert Trumbly, Kam C. Yeung
Summary: Breast cancer is the second most common cancer in women worldwide, and the regulation of its metastasis is not well understood. RKIP has been shown to suppress breast cancer metastasis by downregulating elements of the immune system. In addition to its negative regulation of the Raf signaling pathway, RKIP may exert its effects on cancer through modulating various signaling pathways, including those involved in immune response.
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Yogesh Saxena, Sanjeev Routh, Arunika Mukhopadhaya
Summary: Osteoporosis, a result of bone remodeling imbalance, is closely related to the immune system and inflammatory diseases. Inflammatory mediators play a critical role in the pathogenesis of osteoporosis. Both innate and adaptive immune cells contribute to osteoporosis, with innate cells being the major effectors of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Huaguo Tang, Yuanjie Gu, Lei Jiang, Gang Zheng, Zhuoer Pan, Xiugui Jiang
Summary: Spinal cord injury (SCI) is a devastating neurological condition worldwide. The immune response plays a crucial role in tissue regeneration and functional recovery from SCI. New biological technologies have allowed for more precise classification of the heterogeneity of immune components. This review focuses on the roles of various immune cells and chemicals in SCI and summarizes clinical trials of immunomodulatory therapies and promising therapeutic drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jianrui Zheng, Zhi Yao, Lixiang Xue, Deli Wang, Zhen Tan
Summary: Osteonecrosis is caused by the death of bone marrow cells, leading to abnormal immune function and chronic inflammation that interferes with bone regeneration and repair. Osteoimmunology explores the interactions between immune cells and bone cells, and understanding the chronic inflammatory environment regulated by abnormal osteoimmune function can help develop new treatments for osteonecrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Diego M. Avella Patino, Vijay Radhakrishnan, Kanve N. Suvilesh, Yariswamy Manjunath, Guangfu Li, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Wesley C. Warren, Jussuf T. Kaifi, Jonathan B. Mitchem
Summary: This review article summarizes the role of epigenetic regulation in immune response in a wide range of cancers, including the epigenetic changes in immune cells such as T cells, macrophages, and natural killer cells.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Immunology
Safia Iqbal, Deok-Chun Yang, Ramya Mathiyalagan, Md. Rezaul Karim, Se Chan Kang
Summary: Tuft cells, also known as taste chemosensory cells, have powerful immunomodulatory effects and play important roles in defending against diseases. They are the primary source of interleukin-25 and trigger the production of cytokines, such as IL-13, which further increases IL-25. In addition to their role in the immune system, tuft cells also produce biological effector molecules and provide a physical mucus barrier against the external environment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wenfeng Zeng, Xiaozhe Yin, Yunhan Jiang, Lingtao Jin, Wei Liang
Summary: The dysregulated lipid metabolism in cancer has attracted attention, with immune cells and cancer cells competing for nutrients in the tumor microenvironment. Reprogramming of lipid metabolism towards fatty acid oxidation is closely linked to the immunosuppressive phenotype of tumor-infiltrated immune cells.
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Shanqi Guo, Yingjie Jia, Xiaoyu Yu, Ruiyu Mou, Xiaojiang Li
Summary: Hispidulin has inhibitory effects on the development of prostate cancer by activating PPAR gamma and enhancing autophagy, revealing its anticancer properties.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Liuqian Xu, Suning Che, Huiqing Chen, Qian Liu, Juanjuan Shi, Jianhua Jin, Yongzhong Hou
Summary: As a master transcription factor, c-Myc promotes tumor immune escape. The role of PPARγ in c-Myc-mediated tumor immune escape is unclear. This study found that the PPARγ agonist pioglitazone reduced c-Myc protein expression by inducing its ubiquitination and degradation. Additionally, pioglitazone inhibited the expression of immune checkpoint proteins PD-L1 and CD47, thus inhibiting tumor immune escape mediated by c-Myc.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Genetics & Heredity
Yuma Gohara, Nahoko Tomonobu, Rie Kinoshita, Junichiro Futami, Lena Audebert, Youyi Chen, Ni Luh Gede Yoni Komalasari, Fan Jiang, Chikako Yoshizawa, Hitoshi Murata, Ken-ichi Yamamoto, Masami Watanabe, Hiromi Kumon, Masakiyo Sakaguchi
Summary: The Ad-REIC vector is capable of suppressing cancer through multiple pathways, including REIC/Dkk-3-mediated apoptosis, induction of IL-7 production, and promotion of dendritic cell polarization. Recently, it has been discovered that the extracellular REIC/Dkk-3 protein can regulate an immune checkpoint by modulating PD-L1 on the cancer-cell surface. This is achieved by competing with CMTM6 for PD-L1 binding, resulting in PD-L1 degradation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
