Article
Immunology
Hongbo Zhang, Taylor Alford, Shuangquan Liu, Dongming Zhou, Jieru Wang
Summary: Influenza virus infection decreases the expression of PPAR gamma in macrophages, leading to inflammation and lung injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychology, Multidisciplinary
Lia Araujo, Laetitia Teixeira, Rosa Marina Afonso, Oscar Ribeiro
Summary: Previous research has shown that will to live is a strong predictor for survival among older people, irrespective of age, gender, and comorbidities. Positive attitudes and life satisfaction at age 100 are common, but a longing for death is also present. Factors such as having a Catholic religion, annoyance, uselessness, and loss of meaning are associated with willingness to live longer.
FRONTIERS IN PSYCHOLOGY
(2021)
Editorial Material
Hematology
Jamel El-Benna, Pham My-Chan Dang
Summary: The study demonstrates the crucial role of PD-L1 in delaying neutrophil apoptosis at the site of inflammation by activating the PI3K-AKT survival pathway.
Editorial Material
Neurosciences
Nicole Y. Tsai, Derek S. Welsbie, Xin Duan
Summary: In this issue, three studies present new strategies for uncovering mediators of retinal neuroprotection and optic nerve regeneration, including transcriptional regulators and molecular targets.
Article
Biology
Yuvaraj Sivamani, Dhivya Shanmugarajan, T. Durai Ananda Kumar, Syed Faizan, Bhavya Channappa, Namburu Lalitha Naishima, B. R. Prashantha Kumar
Summary: A protocol for developing novel PPARγ antagonists was reported in this study, involving virtual screening for ligands with anticancer properties, model validation and screening, as well as synthesis and validation of Cpd31 for binding to PPARγ and anti-cancer effects.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ye-Ji Lee, Kiyoon Kim, Minsuk Kim, Young-Ho Ahn, Jihee Lee Kang
Summary: This study demonstrates that activation of the STAT6 signaling pathway mediates PPAR gamma expression and activation in macrophages to resolve acute inflammation. Inhibition of STAT6 activation delays recovery of PPAR gamma expression and activity, as well as impairs efferocytosis.
Review
Immunology
Daniel Toobian, Pradipta Ghosh, Gajanan D. Katkar
Summary: This review article focuses on the potential roles of peroxisome proliferator-activated receptors (PPARs) in macrophage biology, as well as the modulation of immune cell function, microbial infection, and inflammatory diseases by dual and pan PPAR agonists.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Ann A. Coulter, Frank L. Greenway, Dachuan Zhang, Sujoy Ghosh, Cathryn R. Coulter, Sarah L. James, Yanlin He, Luke A. Cusimano, Candida J. Rebello
Summary: Naringenin, an activator found in citrus fruits, has beneficial effects on thermogenesis and insulin sensitivity. Our study investigated if carotenoids can enhance the metabolic effects of naringenin on adipocytes. Results showed that beta-carotene acts synergistically with naringenin to improve thermogenesis and glucose metabolism genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Microbiology
Matthew J. Culyba, Daria Van Tyne
Summary: Studying within-host bacterial evolution during human infection can provide insights into antibiotic resistance, pathogenesis, and transmission, helping in the design of new approaches to combat bacterial infections.
Article
Biochemistry & Molecular Biology
Vladimir Sobolev, Anastasia Nesterova, Anna Soboleva, Alexandre Mezentsev, Evgenia Dvoriankova, Anastas Piruzyan, Elena Denisova, Olga Melnichenko, Irina Korsunskaya
Summary: Our study demonstrates the involvement of PPAR-gamma in the development of psoriatic lesions, with laser treatment restoring its expression. The transcriptional regulation of PPAR-gamma is correlated with the expression of genes such as IL17, STAT3, FOXP3, and RORC in psoriatic skin and T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Xiaomin Su, Mengli Jin, Chen Xu, Yunhuan Gao, Yazheng Yang, Houbao Qi, Qianjing Zhang, Xiaorong Yang, Wang Ya, Yuan Zhang, Rongcun Yang
Summary: This study reveals that FABP4 in the Paneth cells can downregulate the expression of defensins by degrading PPAR-gamma. This downregulation not only occurs in mice, but also in humans. Additionally, a high-fat diet induces an increase in FABP4 in Paneth cells, leading to a decrease in defensin expression. These findings are important for understanding the underlying factors of modern diseases.
Article
Food Science & Technology
Jisong Ahn, Hyo Jeong Son, Hyo Deok Seo, Tae Youl Ha, Jiyun Ahn, Hyunjung Lee, Seung Ho Shin, Chang Hwa Jung, Young Jin Jang
Summary: The study demonstrated that gamma-Oryzanol enhances skeletal muscle function in aged mice by regulating PPAR delta and ERR gamma activity, improving oxidative capacity and attenuating muscle weakness without significant muscle gain.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Immunology
Imen Bendaya, Awatef Ben Jemaa, Ghada Sahraoui, Maher Kharrat, Wissem Sdiri, Ridha Oueslati
Summary: The study aimed to investigate the role of signaling pathways (STAT1/6) and immunometabolism regulators (leptin and PPARs) in the development of type 2 diabetes mellitus (T2DM) with and without cardiovascular diseases (CVD), as well as the correlation with CD14 dynamics in peripheral blood mononuclear cells (PBMCs). The results showed that T2DM patients with CVD had higher levels of leptin expression correlated with STAT1, while T2DM patients without CVD had elevated PPAR expression correlated with STAT6. Additionally, the ratio of PPAR gamma/PPAR alpha was higher in the T2DM with CVD group, and CD14 expression was significantly reduced. These findings suggest potential therapeutic targets for T2DM and related diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia (PE) is a major cause of maternal-fetal morbidity and mortality worldwide. This research shows that placental activation of PPAR gamma can improve the secretion of angiogenic proteins and enhance endothelial function in PE.
Article
Pathology
Wenjun Kang, Sabah Kadri, Rutika Puranik, Michelle N. Wurst, Sushant A. Patil, Ibro Mujacic, Sonia Benhamed, Nifang Niu, Chao Jie Zhen, Bekim Ameti, Bradley C. Long, Filipo Galbo, David Montes, Crystal Iracheta, Venessa L. Gamboa, Daisy Lopez, Michael Yourshaw, Carolyn A. Lawrence, Dara L. Aisner, Carrie Fitzpatrick, Megan E. McNerney, Y. Lynn Wang, Jorge Andrade, Samuel L. Volchenboum, Larissa Furtado, Lauren L. Ritterhouse, Jeremy P. Segal
JOURNAL OF MOLECULAR DIAGNOSTICS
(2018)
Letter
Pathology
Y. Lynn Wang
JOURNAL OF MOLECULAR DIAGNOSTICS
(2018)
Article
Oncology
Greg P. Coffey, Jiajia Feng, Andreas Betz, Anjali Pandey, Matt Birrell, Janet M. Leeds, Kenneth Der, Sabah Kadri, Pin Lu, Jeremy Segal, Y. Lynn Wang, Glenn Michelson, John T. Curnutte, Pamela B. Conley
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Seung-Cheol Lee, Alexander A. Shestov, Lili Guo, Qian Zhang, Jeffrey C. Roman, Xiaobin Liu, Hong Y. Wang, Stephen Pickup, Kavindra Nath, Pin Lu, Samuel Hofbauer, Clementina Mesaros, Y. Lynn Wang, David S. Nelson, Stephen J. Schuster, Ian A. Blair, Jerry D. Glickson, Mariusz A. Wasik
MOLECULAR CANCER RESEARCH
(2019)
Review
Pathology
Jimmy Lee, Y. Lynn Wang
JOURNAL OF MOLECULAR DIAGNOSTICS
(2020)
Article
Hematology
Wenjun Wu, Weige Wang, Carrie A. Franzen, Hui Guo, Jimmy Lee, Yan Li, Madina Sukhanova, Dong Sheng, Girish Venkataraman, Mei Ming, Pin Lu, Anhui Gao, Chunmei Xia, Jia Li, Liang Leo Zhang, Vivian Changying Jiang, Michael L. Wang, Jorge Andrade, Xiaoyan Zhou, Y. Lynn Wang
Summary: Inhibition of B-cell receptor signaling by ibrutinib affects cell adhesion in mantle cell lymphoma, with RAC2 playing a crucial role. This study highlights the importance of RAC2 and cell adhesion in MCL pathogenesis and drug development, demonstrating a novel link between BCR signaling and cell adhesion.
Article
Oncology
Pin Lu, Shengchun Wang, Carrie A. Franzen, Girish Venkataraman, Rebecca McClure, Lei Li, Wenjun Wu, Nifang Niu, Madina Sukhanova, Jianming Pei, Donald A. Baldwin, Reza Nejati, Mariusz A. Wasik, Nadia Khan, Yifan Tu, Juehua Gao, Yihua Chen, Shuo Ma, Richard A. Larson, Y. Lynn Wang
Summary: Ibrutinib and venetoclax are effective as monotherapy for CLL, with better results when used in combination. They target different subpopulations within CLL and effectively reduce both subpopulations. Using a proliferation model may help identify novel drug combinations for eradicating residual disease.
BLOOD CANCER JOURNAL
(2021)
Meeting Abstract
Hematology
Y. Lynn Wang, Ji Ma, Vinay Mallikarjuna, Pin Lu, Shengchun Wang, Sahar Poureghbali, Mariusz A. Wasik, Reza Nejati, Wenjun Wu
Review
Hematology
Shazia Nakhoda, Aldana Vistarop, Y. Lynn Wang
Summary: Bruton tyrosine kinase inhibitors (BTKi) have had a significant impact on the treatment of chronic lymphocytic leukaemia (CLL) and non-Hodgkin lymphoma. However, resistance to BTKi remains a challenge, and this review article provides an update on the key clinical data, mechanisms of resistance, and ongoing clinical investigations in CLL, mantle cell lymphoma, and diffuse large B-cell lymphoma (DLBCL).
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenjun Wu, Pin Lu, Priyal Patel, Ji Ma, Kathy Qi Cai, Vinay S. Mallikarjuna, Sahar Poureghbali, Shazia R. Nakhoda, Reza Nejati, Y. Lynn Wang
Summary: Loss of SHP1 can serve as an alternative biomarker to identify patients who potentially benefit from ibrutinib treatment, and reducing SHP1 pharmacologically may represent a new strategy to augment tumor response to BCR-directed therapies.
Correction
Hematology
Jimmy Lee, Liang Leo Zhang, Wenjun Wu, Hui Guo, Yan Li, Madina Sukhanova, Girish Venkataraman, Shengjian Huang, Hui Zhang, Mir Alikhan, Pin Lu, Ailin Guo, Natalie Galanina, Jorge Andrade, Michael L. Wang, Y. Lynn Wang
Article
Hematology
Jimmy Lee, Liang Leo Zhang, Wenjun Wu, Hui Guo, Yan Li, Madina Sukhanova, Girish Venkataraman, Hui Zhang, Mir Alikhan, Pin Lu, Ailin Guo, Natalie Galanina, Jorge Andrade, Michael L. Wang, Y. Lynn Wang
Meeting Abstract
Pathology
Shiraz Fidai, Madina Sukhanova, Y. Lynn Wang, Sonali Smith, Wendy Stock, Elizabeth Hyjek, Girish Venkataraman
Meeting Abstract
Medicine, Research & Experimental
Shiraz Fidai, Madina Sukhanova, Y. Lynn Wang, Sonali Smith, Wendy Stock, Elizabeth Hyjek, Girish Venkataraman
LABORATORY INVESTIGATION
(2018)
Article
Oncology
Mei Ming, Wenjun Wu, Bingqing Xie, Madina Sukhanova, Weige Wang, Sabah Kadri, Shruti Sharma, Jimmy Lee, Sharon Shacham, Yosef Landesman, Natalia Maltsev, Pin Lu, Y. Lynn Wang
MOLECULAR CANCER THERAPEUTICS
(2018)
