Journal
PPAR RESEARCH
Volume 2008, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2008/821592
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Funding
- JG Foundation
- Research to Prevent Blindness (Wilmer Eye Institute)
- Research to Prevent Blindness Career Development Award
- William Weis Award
- Jack and Gail Baylin Philanthropic Fund
- JHU
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The peroxisome proliferator-activated receptors (PPAR's) are members of the steroid/thyroid nuclear receptor, superfamily of transcription factors. There are currently three known PPAR subtypes, alpha, beta, and gamma. The PPARs are now recognized participants in a number of biological pathways some of which are implicated in the pathogenesis of age-related macular degeneration (AMD). These include immune modulation, lipid regulation, and oxidant/antioxidant pathways important to the onset and progression of dry AMD, and vascular endothelial growth factor (VEGF) mediated pathways that stimulate choroidal neovascularization (CNV), characteristic of wet AMD. PPAR-alpha is found in retina and also on vascular cells important to formation of CNV. At this time, however, relatively little is known about potential contributions of PPAR-alpha to the pathogenesis of dry and wet AMD. This review examines current literature for potential roles of PPAR-alpha in the pathogenesis and potential treatment of AMD with emphasis on prevention and treatment of wet AMD. Copyright (C) 2008 M. del V Cano and P. L. Gehlbach.
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