Review
Medicine, General & Internal
Hassan Kamran, Hani Jneid, Waleed T. Kayani, Salim S. Virani, Glenn N. Levine, Vijay Nambi, Umair Khalid
Summary: Dual antiplatelet therapy is beneficial for patients with acute coronary syndrome, and the specific combination and duration should be based on patient characteristics and bleeding risk.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ji Woong Roh, SungA Bae, Yongcheol Kim, Nak-Hoon Son, Deok-Kyu Cho, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Myung Ho Jeong, Yangsoo Jang
Summary: The study indicated that in patients with AMI who underwent second-generation DES implantation, SAPT was associated with a lower rate of MACCE between 12 and 36 months compared to DAPT. This finding was consistent even in patients with complex features, suggesting the potential benefits of SAPT in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chen-Shuan Chung, Chieh-Chang Chen, Kuan-Chih Chen, Yu-Jen Fang, Wen-Feng Hsu, Yen-Nien Chen, Wei-Chuang Tseng, Cheng-Kuan Lin, Tzong-Hsi Lee, Hsiu-Po Wang, Yen-Wen Wu
Summary: The efficiency and safety of early endoscopy (EE) for acute upper gastrointestinal bleeding (UGIB) in acute coronary syndrome (ACS) patients needs to be further investigated. This study showed that EE can better control bleeding, reduce the 3-day rebleeding rate and transfusion needs, but has more complications in male patients.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Luiz Sergio Fernandes de Carvalho, Gustavo Alexim, Ana Claudia Cavalcante Nogueira, Marta Duran Fernandez, Tito Barbosa Rezende, Sandra Avila, Ricardo Torres Bispo Reis, Alexandre Anderson Munhoz Soares, Andrei Carvalho Sposito
Summary: Acute coronary syndrome (ACS) is a common cause of death in individuals older than 55 years. Young individuals with ACS (yACS) have unique epidemiologic features and require specific prediction rules to improve time-dependent prediction metrics. By exploring temporal framing structures and using subgroup-specific prediction rules, the predictive accuracy for adverse clinical events in yACS can be optimized, leading to a higher detection rate compared to using rules designed for the global cohort.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Elmir Omerovic, David Erlinge, Sasha Koul, Ole Frobert, Jonas Andersson, Johan Ponten, Fredrik Bjoerklund, Robert Kastberg, Max Petzold, Charlotta Ljungman, Kristian Bolin, Bjorn Redfors
Summary: The SWITCH SWEDEHEART study is a prospective, multicenter, open-label, cross-sectional, stepped-wedge cluster-randomized clinical trial that aims to evaluate the relative efficacy of prasugrel versus ticagrelor in a real-world cohort of patients with non-ST-elevation ACS. It will provide an extensive randomized comparison between the two medications and establish an important standard for evaluating healthcare changes.
AMERICAN HEART JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St. Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: In acute coronary syndrome following percutaneous coronary intervention, newer P2Y12 inhibitors (ticagrelor and prasugrel) reduce cardiovascular outcomes compared to clopidogrel, but have a higher bleeding risk. This study examines the safety of each inhibitor in a real-world population.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Hiroyoshi Mori, Takuya Mizukami, Atsuo Maeda, Kazuki Fukui, Yoshihiro Akashi, Junya Ako, Yuji Ikari, Toshiaki Ebina, Kouichi Tamura, Atsuo Namiki, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
Summary: The 1-year rates of ischemic and bleeding events were similar in Japanese patients with AMI treated with prasugrel or clopidogrel.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Erik Bjorklund, Carl Johan Malm, Susanne J. Nielsen, Emma C. Hansson, Hans Tygesen, Birgitta S. Romlin, Andreas Martinsson, Elmir Omerovic, Aldina Pivodic, Anders Jeppsson
Summary: This study compared clinical outcomes of patients with acute coronary syndrome treated with aspirin and ticagrelor vs aspirin alone after artery bypass grafting. The results showed that dual antiplatelet therapy did not significantly reduce major adverse cardiovascular events compared with aspirin monotherapy, but was associated with an increased risk of major bleeding. Further research is needed to determine optimal antiplatelet therapy in this group.
Review
Medicine, General & Internal
Brian A. Bergmark, Njambi Mathenge, Piera A. Merlini, Marilyn B. Lawrence-Wright, Robert P. Giugliano
Summary: Although progress has been made in diagnosing and treating acute coronary syndromes, cardiovascular disease remains a leading cause of death globally. High-sensitivity troponin assays have allowed for rapid diagnosis in suspected cases. Dual antiplatelet therapy and additional preventive measures are recommended. The diagnosis and management of acute coronary syndromes continue to evolve, especially in response to the COVID-19 pandemic.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ke Shi, Meng-Xi Yang, Chun-Chao Xia, Wan-Lin Peng, Kun Zhang, Zhen-Lin Li, Ying-Kun Guo, Zhi-Gang Yang
Summary: This study found that breathing maneuvers in healthy rabbits induced oxygenation changes comparable to stress testing, while in acute MI rabbits, the effects induced by breathing maneuvers were equally effective as adenosine stress. This suggests that combined breathing maneuvers with OS-MRI have the potential to be used as a nonpharmacological alternative for assessing myocardial oxygenation in patients with acute MI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Hematology
Panagiotis T. Tasoudis, Loannis G. Kyriakoulis, Dimitrios Sagris, Hans Christoph Diener, George Ntaios
Summary: This study compared the safety and efficacy of clopidogrel versus aspirin in patients with established cardiovascular disease. The results showed no significant difference between the two drugs in terms of all-cause mortality, ischemic stroke, and major bleeding rates. However, patients receiving clopidogrel had a slightly lower risk for nonfatal myocardial infarction and major adverse cardiovascular events.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biotechnology & Applied Microbiology
Yao Xie, Hongzhou Zhang, Tieqiu Huang
Summary: Acute myocardial infarction (AMI) is a leading cause of death globally. Exosomes, which carry important intercellular communication information, may serve as diagnostic markers for various diseases. In this study, a label free proteomics strategy was used to identify differentially expressed proteins in AMI patients' plasma exosomes. Bioinformatics analysis and enzyme-linked immunosorbent assay were then employed to validate the candidate proteins. Our findings revealed potential biomarkers, PLG, C8B, and F2, for early AMI diagnosis, suggesting their potential diagnostic value for AMI.
Article
Physiology
Keren A. S. Bello, Maria Clara B. Wilke, Rakel P. Simoes, Maicon Landim-Vieira, Paulina Langa, Ivanita Stefanon, Dalton Valentim Vassallo, Aurelia Araujo Fernandes
Summary: This study suggests that exposure to mercury exacerbates the impact of cardiac ischemic injury, leading to an increased mortality rate among patients experiencing acute myocardial infarction.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhangfeng Yu, Hua Zhou, Baoshuai Shan, Jianzhong Fu, Hao Zhu, Qian Feng, Rong Shen, Xing Jin
Summary: This study found no difference in the development of pneumonia between clopidogrel and aspirin in acute ischemic stroke patients, but in minor stroke patients, clopidogrel appeared to increase the risk of pneumonia.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Pharmacology & Pharmacy
Meina Lv, Xiaochun Zheng, Tingting Wu, Wenjun Chen, Shaojun Jiang, Hongqin Zhang, Fangda Xu, Jinhua Zhang
Summary: An established score named (ABC)(2)D was developed to predict the risk of gastrointestinal bleeding, incorporating seven risk factors. The (ABC)(2)D score outperformed the CRUSADE score in predicting acute gastrointestinal bleeding risk. This new risk-scoring model may help identify patients at significant risk of gastrointestinal bleeding.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Parasitology
Rasha F. Mady, Wessam El-Hadidy, Samar Elachy
PARASITOLOGY RESEARCH
(2016)
Article
Surgery
Mahmoud M. Farag, Asmaa A. Khalifa, Wessam F. Elhadidy, Radwa M. Rashad
JOURNAL OF SURGICAL RESEARCH
(2016)
Article
Chemistry, Multidisciplinary
Nesrine S. El-Mezayen, Wessam F. El-Hadidy, Wessam M. El-Refaie, Th. I. Shalaby, Mahmoud M. Khattab, Aiman S. El-Khatib
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Genetics & Heredity
Doaa Ali Abdelmonsif, Ahmed S. Sultan, Wessam F. El-Hadidy, Dina Mohamed Abdallah
MOLECULAR DIAGNOSIS & THERAPY
(2018)
Article
Chemistry, Multidisciplinary
Nesrine S. El-Mezayen, Wessam F. El-Hadidy, Wessam M. El-Refaie, Thanaa I. Shalaby, Mahmoud M. Khattab, Aiman S. El-Khatib
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Pharmacology & Pharmacy
Adham R. Mohamed, Wessam F. El-Hadidy
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Samar R. Saleh, Sherien A. Abdelhady, Amira R. Khattab, Wessam F. El-Hadidy
JOURNAL OF CHEMICAL NEUROANATOMY
(2020)
Article
Multidisciplinary Sciences
Asmaa A. Khalifa, Radwa M. Rashad, Wessam F. El-Hadidy
Summary: The study investigated the role of thymoquinone in preserving cardiac mtDNA content and ameliorating cardiac injuries induced by myocardial infarction. Results showed that thymoquinone reversed histopathological changes, decreased serum cardiac markers, oxidative stress, inflammation, and apoptosis, while preserving cardiac mtDNA content. Thymoquinone is demonstrated to be a cardioprotective agent with extended effects on cardiac mtDNA preservation and various cardioprotective actions.
Article
Pharmacology & Pharmacy
Passant M. Elhalmoushy, Manal A. Elsheikh, Noura A. Matar, Wessam F. El-Hadidy, Maher A. Kamel, Gamal A. Omran, Yosra S. R. Elnaggar
Summary: This study introduces and evaluates a novel hyaluronate integrated gel-core oleosomes system for improving the permeability of berberine in the skin, aiming to treat vitiligo. The results demonstrate that this system significantly enhances the retention of berberine in human skin, enabling effective local targeted treatment with antioxidant and anti-inflammatory effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Urology & Nephrology
Mahmoud M. Farag, Sally M. Ahmed, Wessam F. Elhadidy, Radwa M. Rashad
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2019)
