Article
Ophthalmology
Federico Bernabei, Ianis Marcireau, Francesca Frongia, Frederic Azan, Aldo Vagge, Enrico Peiretti, Gilles Guerrier, Pierre-Raphael Rothschild
Summary: This study aimed to investigate the prevalence of cystoid macular edema after pars plana vitrectomy for the treatment of pseudophakic rhegmatogenous retinal detachment and identify possible related risk factors. The study data showed that the prevalence of cystoid macular edema was 17.1%, and severe proliferative vitreoretinopathy and laser retinopexy were identified as independent risk factors for the development of cystoid macular edema.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Matthew R. Starr, Louis Cai, Anthony Obeid, Edwin H. Ryan, Dean Eliott, Claire Ryan, Nora J. Forbes, Michael Ammar, Luv G. Patel, Antonio Capone, Geoffrey G. Emerson, Daniel P. Joseph, Omesh P. Gupta, Carl D. Regillo, Jason Hsu, Yoshihiro Yonekawa
Summary: The study found that the major risk factors for developing CME following repair of rhegmatogenous retinal detachments were recurrent RRD, preexisting PVR, older age, and cataract surgery following RRD repair.
CURRENT EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Malik Merad, Fabien Verite, Florian Baudin, Ines Ben Ghezala, Cyril Meillon, Alain Marie Bron, Louis Arnould, Petra Eid, Catherine Creuzot-Garcher, Pierre-Henry Gabrielle
Summary: This study aimed to describe the rate and outcomes of cystoid macular edema (CME) after pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment (RRD) and identify the associated risk factors and imaging characteristics. The study found that worse presenting visual acuity, grade C proliferative vitreoretinopathy, endolaser retinopexy, and cataract surgery within 6 months of the initial RRD repair were risk factors for postoperative CME at 12 months.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Min Xu, Huirong Xu, Xiao Li, Fang Chen
Summary: The study analyzed and compared the macular morphology and microcirculation characteristics in DME patients with and without SRD. The results suggest that disruptions in EZ and ELM, increased number of HF, and thickening and hyperperfusion of the choroid may be involved in the pathogenesis of SRD in DME.
Article
Endocrinology & Metabolism
Kuebra Ozata Gundogdu, Emine Dogan, Erkan celik, Guersoy Alagoz
Summary: This study evaluated the outcomes of IVR treatment in patients with DME, including those with and without SRD. The results showed that both groups experienced improvements in visual acuity and macular thickness after three consecutive IVR injections. However, patients with SRD had lower visual gains compared to those without SRD.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Dariusz Tarasewicz, Carol Conell, Lisa K. Gilliam, Ronald B. Melles
Summary: The study aimed to determine the importance of blood sugar control, blood pressure, and other systemic factors on the risk of diabetic retinopathy progression. The findings confirmed that glucose control, as measured by HbA1c, was the most important modifiable risk factor, followed by blood pressure control and total cholesterol. Non-white patients generally had a higher risk of progression to diabetic retinopathy, while Asian patients were less likely to develop diabetic macular edema.
ACTA DIABETOLOGICA
(2023)
Article
Multidisciplinary Sciences
Huiling Tan, Xin Wang, Kaiyou Ye, Jianmin Lin, E. Song, Lihua Gong
Summary: This study investigated the prevalence and risk factors of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus (T2DM) in Qingpu, Shanghai. The prevalence of DR was 10.1%, with non-proliferative DR being more common. Higher fasting plasma glucose and glycated hemoglobinA1c were identified as known risk factors for DR, while no association was found between lipid indicators and DR. Additionally, higher levels of urea nitrogen and urinary albumin were associated with an increased risk of DR.
Review
Medicine, General & Internal
Ryo Terao, Ryosuke Fujino, Tazbir Ahmed
Summary: Retinal occlusive diseases, including retinal artery occlusion and retinal vein occlusion, are common causes of visual impairment. These diseases have different pathophysiologies and require different treatment approaches. Prompt examinations and interventions for systemic vascular diseases are necessary for patients with retinal artery occlusion, which is mainly caused by thromboembolism. Retinal vein occlusion, characterized by retinal hemorrhage and ischemia, can lead to visual impairment through various complications. While anti-vascular endothelial growth factor therapy is the first-line treatment for retinal vein occlusion, other treatment protocols and new therapeutic options are under investigation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Cemal Ozsaygili, Bekir Kucuk, Yener Yildirim
Summary: In this retrospective cohort study of treatment-naive diabetic macular oedema patients, the efficacy of aflibercept treatment in improving central retinal thickness and best-corrected visual acuity was not affected by the presence or development of posterior vitreous detachment (PVD).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chaoyang Zhang, Dawei Luo, Hai Xie, Qian Yang, Dandan Liu, Lei Tang, Jingting Zhang, Weiye Li, Haibin Tian, Lixia Lu, Xiaodong Sun, Guo-Tong Xu, Jingfa Zhang
Summary: Retinal Muller glial dysfunction and intracellular edema in diabetic retinopathy (DR) are associated with down-regulation of Aquaporin 11 (AQP11). AQP11 overexpression alleviates intracellular edema, enhances glutamate metabolism, and reduces cell death. The down-regulation of AQP11 in DR is mediated by the miRNA-AQP11 axis, which is partially reversed by AQP11 overexpression. Targeting AQP11 regulation may provide a new therapeutic strategy for diabetic macular edema (DME).
PHARMACOLOGICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Luisa Frizziero, Andrea Calciati, Giulia Midena, Tommaso Torresin, Raffaele Parrozzani, Elisabetta Pilotto, Edoardo Midena
Summary: Subthreshold micropulse laser treatment has shown potential in treating diabetic macular edema, but its mechanism of action and most effective treatment methods are not yet fully understood, requiring further research. The treatment appears to normalize specific retinal neuroinflammatory metabolic pathways long-term, contributing to the restoration of retinal homeostasis and the curtailing of local inflammatory processes. Optimized and standardized parameters are key to ensuring effective and safe treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Francesco Pignatelli, Annalisa Nacucchi, Alfredo Niro, Samuele Gigliola, Fedele Passidomo, Rossella Donghia, Giuseppe Addabbo
Summary: In this study, we investigated the efficacy and safety of DEX-I combined with silicone oil (SO) removal for the treatment of recalcitrant cystoid macular edema (CME) after successful rhegmatogenous retinal detachment (RRD) repair. The results showed that DEX-I treatment significantly improved CME and visual acuity, and was safe to use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jayoung Ahn, Daniel Duck-Jin Hwang
Summary: This study evaluated longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in eyes affected with branch and central retinal vein occlusion (BRVO and CRVO, respectively) and fellow eyes. It found that the global pRNFL thickness of fellow eyes in the BRVO and CRVO groups decreased significantly at 24 months compared to baseline, while the fellow eyes of patients with CRVO had significantly lower pRNFL thickness at 12 and 24 months compared to those of the BRVO and normal control groups. These results suggest that fellow eyes of patients with BRVO and CRVO are susceptible to pRNFL damage.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jianan Li, Ruotian Xie, Feng Jiang, Yiming Li, Yanfang Zhu, Zhiheng Liu, Mengyu Liao, Yuanyuan Liu, Xiangda Meng, Song Chen, Jinguo Yu, Mei Du, Xiaohong Wang, Yupeng Chen, Hua Yan
Summary: TL1A loss in the retina leads to increased vascular permeability in DR, and TL1A treatment is potentially therapeutic for DME.
Article
Multidisciplinary Sciences
Jingzhen He, Junxia Wang, Zeyu Han, Jun Ma, Chongjing Wang, Meng Qi
Summary: Retinal illnesses can cause irreversible blindness, but optical coherence tomography (OCT) can help with diagnosis. Computer-aided diagnosis algorithms can automatically analyze and diagnose OCT images, improving efficiency. This study proposes an interpretable Swin-Poly Transformer network for automatic retinal OCT image classification, achieving high accuracy and providing confidence score maps for better understanding of the models' decision-making process.
SCIENTIFIC REPORTS
(2023)
Review
Ophthalmology
Daniel Shu Wei Ting, Louis R. Pasquale, Lily Peng, John Peter Campbell, Aaron Y. Lee, Rajiv Raman, Gavin Siew Wei Tan, Leopold Schmetterer, Pearse A. Keane, Tien Yin Wong
BRITISH JOURNAL OF OPHTHALMOLOGY
(2019)
Review
Ophthalmology
Rajiv Raman, Sangeetha Srinivasan, Sunny Virmani, Sobha Sivaprasad, Chetan Rao, Ramachandran Rajalakshmi
Article
Ophthalmology
Gitanjli Sood, Vinata Rajendran, Ronnie George, Tarun Sharma, Rajiv Raman
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Medicine, Research & Experimental
Karthikka Palanisamy, Rajiv Raman, Konerirajapuram Natarajan Sulochana, Subbulakshmi Chidambaram
MEDICAL HYPOTHESES
(2019)
Article
Ophthalmology
Rehana Khan, Sumeer Singh, Janani Surya, Tarun Sharma, Vaitheeswaran Kulothunga, Rajiv Raman
OPHTHALMIC RESEARCH
(2019)
Article
Sport Sciences
G. F. Lopez Sanchez, L. Smith, R. Raman, D. Jaysankar, S. Singh, R. Sapkota, A. Diaz Suarez, S. Pardhan
Article
Ophthalmology
Varun Gulshan, Renu P. Rajan, Kasumi Widner, Derek Wu, Peter Wubbels, Tyler Rhodes, Kira Whitehouse, Marc Coram, Greg Corrado, Kim Ramasamy, Rajiv Raman, Lily Peng, Dale R. Webster
JAMA OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Rupesh Agrawal, Mukesh Jain, Rehana Khan, Durgasri Jaisankar, Wei Xin, Jianbin Ding, Ilaria Testi, Rajiv Raman, Jyotirmay Biswas
Summary: The study analyzed choroidal angioarchitecture in patients with sympathetic ophthalmia using SS-OCT images and found a significant increase in CVI as a novel noninvasive biomarker of disease activity. SS-OCT provides useful qualitative and quantitative parameters for potential use in diagnosing and monitoring patients with SO.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Md Shahid Alam, Mukesh Jain, Bipasha Mukherjee, Tarun Sharma, Swatee Halbe, Durgasri Jaisankar, Rajiv Raman
SCIENTIFIC REPORTS
(2019)
Editorial Material
Ophthalmology
Anmol U. Naik, Rajiv Raman
JAMA OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Durgasri Jaisankar, Meenakshi Kumar, Pukhraj Rishi, Sumeer Singh, Rajiv Raman
THERAPEUTIC ADVANCES IN OPHTHALMOLOGY
(2020)
Meeting Abstract
Ophthalmology
John Robson, Rajiv Raman, Rekha Srinivasan, Shahina Pardhan
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Meeting Abstract
Ophthalmology
Shahina Pardhan, Tirthalal Upadhyaya, Anupama Biswas, Rajiv Raman, Raju Sapkota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Correction
Health Care Sciences & Services
Paisan Ruamviboonsuk, Jonathan Krause, Peranut Chotcomwongse, Rory Sayres, Rajiv Raman, Kasumi Widner, Bilson J. L. Campana, Sonia Phene, Kornwipa Hemarat, Mongkol Tadarati, Sukhum Silpa-Archa, Jirawut Limwattanayingyong, Chetan Rao, Oscar Kuruvilla, Jesse Jung, Jeffrey Tan, Surapong Orprayoon, Chawawat Kangwanwongpaisan, Ramase Sukumalpaiboon, Chainarong Luengchaichawang, Jitumporn Fuangkaew, Pipat Kongsap, Lamyong Chualinpha, Sarawuth Saree, Srirut Kawinpanitan, Korntip Mitvongsa, Siriporn Lawanasakol, Chaiyasit Thepchatri, Lalita Wongpichedchai, Greg S. Corrado, Lily Peng, Dale R. Webster
NPJ DIGITAL MEDICINE
(2019)
Article
Health Care Sciences & Services
Paisan Raumviboonsuk, Jonathan Krause, Peranut Chotcomwongse, Rory Sayres, Rajiv Raman, Kasumi Widner, Bilson J. L. Campana, Sonia Phene, Kornwipa Hemarat, Mongkol Tadarati, Sukhum Silpa-Archa, Jirawut Limwattanayingyong, Chetan Rao, Oscar Kuruvilla, Jesse Jung, Jeffrey Tan, Surapong Orprayoon, Chawawat Kangwanwongpaisan, Ramase Sukumalpaiboon, Chainarong Luengchaichawang, Jitumporn Fuangkaew, Pipat Kongsap, Lamyong Chualinpha, Sarawuth Saree, Srirut Kawinpanitan, Korntip Mitvongsa, Siriporn Lawanasakol, Chaiyasit Thepchatri, Lalita Wongpichedchai, Greg S. Corrado, Lily Peng, Dale R. Webster
NPJ DIGITAL MEDICINE
(2019)