Journal
EXPERT REVIEW OF HEMATOLOGY
Volume 6, Issue 4, Pages 411-418Publisher
EXPERT REVIEWS
DOI: 10.1586/17474086.2013.814840
Keywords
divalent metal transporter 1; ferroportin 1; hepcidin; mononuclear phagocyte system; transferrin receptor 1
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Funding
- National Natural Science Foundation of China [10979025]
- Natural Science Foundation of Hebei Province [C2012205082]
- Natural Science Foundation of Distinguished Young Scholar of Hebei Province [C2010002032]
- Science and Technology Research Youth Fund Project of Hebei Colleges and Universities [Q2012036]
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The daily iron absorption and loss are small and iron metabolism in human is characterized by a limited external exchange and by an efficient reutilization of iron from internal sources. The mononuclear phagocyte system (MPS) plays a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes, which is important in maintaining iron homeostasis. Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin. Insights into the regulatory mechanisms that control the regulation of iron metabolism proteins in the MPS will deepen our understanding about the molecular mechanism of iron homeostasis and iron-related diseases.
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