Immunoregulation of GVHD by triggering the innate immune system with CpG

In Vitro Experiments Demonstrate that Monocytes and Dendritic Cells are Rendered Apoptotic by Extracorporeal Photochemotherapy, but Exhibit Unaffected Surviving and Maturing Capacity after 30 Gy Gamma Irradiation

(2010) V. Rao et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Induction of Graft-versus-Leukemia (GVL) Effect without Graft-versus-Host Disease (GVHD) by Pretransplant Donor Treatment with Immunomodulators

(2009) Shoshana Morecki et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Advances in the clinical management of GVHD

(2008) James L.M. Ferrara   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

CpG-Induced Myeloid CD11b + Gr-1 + Cells Efficiently Suppress T Cell–Mediated Immunoreactivity and Graft-Versus-Host Disease in a Murine Model of Allogeneic Cell Therapy

(2008) Shoshana Morecki et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity

(2008) R. Nishimura et al.   BLOOD

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

(2008) P. A. Taylor et al.   BLOOD

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

(2008) T. Yi et al.   BLOOD

Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells

(2008) E. Gatza et al.   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD

In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations

(2008) M. J. Carlson et al.   BLOOD

Prevention and treatment of acute GvHD

(2008) C Messina et al.   BONE MARROW TRANSPLANTATION

CpG-ODN-based immunotherapy is effective in controlling the growth of metastasized tumor cells

(2008) Han-A Kim et al.   CANCER LETTERS

Local Administration of PF-3512676 CpG-B Instigates Tumor-Specific CD8+ T-Cell Reactivity in Melanoma Patients

(2008) B. G. Molenkamp et al.   CLINICAL CANCER RESEARCH

Toll-like receptors in the respiratory system: Their roles in inflammation

(2008) Chiaki Iwamura et al.   CURRENT ALLERGY AND ASTHMA REPORTS

The Use of Growth Factors in Hematopoietic Stem Cell Transplantation

(2008) I. Pusic et al.   CURRENT PHARMACEUTICAL DESIGN

Expanded donor natural killer cell and IL-2, IL-15 treatment efficacy in allogeneic hematopoietic stem cell transplantation

(2008) Guanghua Chen et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

IFN-γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease

(2008) David Polchert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prevention of acute graft-vs-host disease by a single low-dose cyclophosphamide injection following allogeneic bone marrow transplantation

(2008) Tatyana B. Prigozhina et al.   EXPERIMENTAL HEMATOLOGY

Immunomodulation and pharmacological strategies in the treatment of graft-versus-host disease

(2008) Minghui Li et al.   EXPERT OPINION ON PHARMACOTHERAPY

Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation

(2008) Andrew R. Rezvani et al.   JOURNAL OF AUTOIMMUNITY

Palifermin Mediates Immunoregulatory Effects in Addition to its Cytoprotective Effects in Mice with Acute Graft-Versus-Host Disease

(2008) Cynthia A. Ellison et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Randomized Phase II Trial of a Toll-Like Receptor 9 Agonist Oligodeoxynucleotide, PF-3512676, in Combination With First-Line Taxane Plus Platinum Chemotherapy for Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Christian Manegold et al.   JOURNAL OF CLINICAL ONCOLOGY

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

(2008) Katarina Le Blanc et al.   LANCET

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

(2008) A M Krieg   ONCOGENE

TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours

(2008) H Conroy et al.   ONCOGENE

Phase 1 Trial of AMA1-C1/Alhydrogel plus CPG 7909: An Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria

(2008) Gregory E. D. Mullen et al.   PLoS One

Suppression of graft-versus-host disease after adoptive infusion of alloreactive NK cells induced by silencing Ly49C gene in mice

(2008) Donglin Cao et al.   TRANSPLANT IMMUNOLOGY

Induction of multispecific Th-1 type immune response against HCV in mice by protein immunization using CpG and Montanide ISA 720 as adjuvants

(2008) Qi Qiu et al.   VACCINE

A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity

(2008) Tatsuya Fukuiwa et al.   VACCINE

NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation

(2007) Loredana Ruggeri et al.   BLOOD CELLS MOLECULES AND DISEASES