Article
Medicine, General & Internal
Jung Eun Yoo, Dahye Kim, Kyungdo Han, Sang Youl Rhee, Dong Wook Shin, Hyun Lee
Summary: The study found that there is an association between diabetes status and the development of tuberculosis. Individuals with diabetes have a higher risk of developing tuberculosis compared to those without diabetes, and the risk of tuberculosis increases with longer duration of diabetes.
Article
Endocrinology & Metabolism
Ravi Retnakaran, Chang Ye, Anthony J. Hanley, Philip W. Connelly, Mathew Sermer, Bernard Zinman
Summary: This study compared postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated. The results showed that treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy. Insulin sensitivity and beta-cell function decreased, while fasting and 2-h glucose levels increased progressively across the five groups.
Article
Multidisciplinary Sciences
Jamil Said, David Lagat, Allan Kimaina, Chrispine Oduor
Summary: The study examined the relationship between serum vitamin D, insulin resistance, and beta cell function in a subpopulation of black Kenyan T2DM patients, and found that 74.1% of patients had vitamin D deficiency, which was positively correlated with beta cell function. The results indicate that beta cell dysfunction is more prominent than insulin resistance in this population.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Shanhu Qiu, Xue Cai, Peilin Zheng, Yang Yuan, Ying Xu, Lijing Jia, Zilin Sun, Tongzhi Wu
Summary: This study examined the association between changes in physical capability and the risk of diabetes and glycemic control in older adults. The findings suggest that changes in physical capability were not associated with a reduced risk of diabetes but may improve insulin resistance.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Kristen Nadeau, Laure El Ghormli, Silva Arslanian, Fida Bacha, Sonia Caprio, Christine C. Chan, Lily Chao, Elvira K. Isganaitis, Maria Rayas, Maggie Siska, Philip Zeitler, TODAY Study Grp
Summary: This study aims to investigate the impact of early attainment of tight glycemic control on long-term β-cell function and glycemic control in youth-onset type 2 diabetes. The research findings suggest that the initial 6 months of glycemic control have an effect on β-cell function and glycemic control over 9 years, and that sex, race/ethnicity, and BMI also influence these relationships.
Article
Endocrinology & Metabolism
Jeff S. Coombes, Katrin A. Dias, Ravin Lal, Robert G. Fassett, Matthew P. Wallen, Joyce S. Ramos, Suzanna Russell, Natalie K. Vear, Trishan Gajanand, Tom G. Bailey, Daniel J. Green, Brooke K. Coombes, Llion A. Roberts
Summary: This study aimed to determine the efficacy of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and investigate any persistent effects 7 weeks after treatment. The results showed that after 7 weeks, the ECP45 group had significantly lower levels of HbA1c compared to the SHAM control group. The findings demonstrate that ECP45 for 7 weeks can improve glycemic control in people with T2D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Nutrition & Dietetics
Stephanie K. Nishi, Effie Viguiliouk, Cyril W. C. Kendall, David J. A. Jenkins, Frank B. Hu, John L. Sievenpiper, Alessandro Atzeni, Anoop Misra, Jordi Salas-Salvado
Summary: Diabetes is a global concern affecting a significant proportion of adults, and nut consumption has been associated with positive health outcomes. There is evidence suggesting that nut consumption may play a role in preventing and managing type 2 diabetes, although more research is needed to confirm these findings.
Article
Nutrition & Dietetics
Jonas Ellerbrock, Benthe Spaanderman, Joris van Drongelen, Eva Mulder, Veronica Lopes van Balen, Veronique Schiffer, Laura Jorissen, Robert-Jan Alers, Jeanine Leenen, Chahinda Ghossein-Doha, Marc Spaanderman
Summary: This study found that both high insulin resistance and beta cell dysfunction increase the risk of gestational diabetes mellitus (GDM) in second-trimester pregnant women. Additionally, high insulin resistance is associated with the need for additional glucose lowering medication, especially in women diagnosed with GDM who do not respond well to a low carbohydrate diet. Therefore, insulin sensitizers may be the most targeted therapeutic modality for diet-insensitive GDM patients.
Article
Nutrition & Dietetics
Farshad Teymoori, Hossein Farhadnejad, Nazanin Moslehi, Parvin Mirmiran, Ebrahim Mokhtari, Fereidoun Azizi
Summary: The study revealed that a diet high in GL, GI, II, and IL can increase the incidence of diabetes. Glycemic and insulin load are stronger predictors of diabetes risk compared to glycemic index and insulin index.
CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Emanuela Di Murro, Gianfranco Di Giuseppe, Laura Soldovieri, Simona Moffa, Ilaria Improta, Umberto Capece, Enrico Celestino Nista, Francesca Cinti, Gea Ciccarelli, Michela Brunetti, Antonio Gasbarrini, Alfredo Pontecorvi, Andrea Giaccari, Teresa Mezza
Summary: Type 2 diabetes is a prevalent disease globally. Lifestyle interventions, particularly exercise, play a crucial role in diabetes management. However, adherence to physical activity guidelines remains challenging. Tailored exercise plans based on individual beta-cell functionality and preferences are needed. Investigating blood glucose responses to different types of exercise can guide personalized treatment recommendations.
Article
Medical Laboratory Technology
Mohamed Mostafa Kamal, Aya Adel, Ghada Hussein Sayed, Shadia Ragab, Dina Hamada Kassem
Summary: The study revealed that SerpinB1 levels were significantly lower in T2DM patients and negatively correlated with α-cell function, glycemic control, and lipid profile parameters. Higher serum SerpinB1 levels were associated with lower susceptibility for T2DM.
TRANSLATIONAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Alexander T. Sipe, Marian L. Neuhouser, Kara L. Breymeyer, Kristina M. Utzschneider
Summary: A controlled feeding study found that a low GI diet reduced glucose exposure and insulin secretion, but had no impact on measures of beta-cell function.
Article
Medicine, General & Internal
Xiaohan Tang, Xiang Yan, Houde Zhou, Gan Huang, Xiaohong Niu, Hongwei Jiang, Heng Su, Xilin Yang, Xia Li, Zhiguang Zhou
Summary: This study found that high insulin resistance is associated with an increased risk of abnormal lipid metabolism in both type 1 and type 2 diabetes patients, while low beta-cell function is not associated with the risk of abnormal lipid metabolism.
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Huijuan Wang, Changming Wang, Xiuping Xuan, Zhouni Xie, Yuanyuan Qiu, Huiping Qin, Zhong Xiaoning
Summary: The study investigated the relationship between baseline ratio of triglyceride to HDL cholesterol (TG/HDL-C) and type 2 diabetes mellitus (T2DM) in Japanese adults. The findings revealed a J-shaped relationship between baseline TG/HDL-C and T2DM risk, and a positive association between TG/HDL-C > 0.35 and the incidence of diabetes mellitus.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Spela Volcansek, Urska Rahne Perc, Mojca Lunder, Drazenka Pongrac Barlovic
Summary: Reactive postprandial hypoglycemia (RPH) is an understudied condition that lacks clinical definition and knowledge of future health implications. This study aimed to assess the glycemic response after glucose ingestion in individuals with RPH and compare it with healthy volunteers. The results showed that RPH subjects did not exhibit deteriorated insulin sensitivity or insulin resistance, and there were no significant differences in glucose-insulin curves during oral glucose tolerance tests compared to healthy controls.
Article
Pharmacology & Pharmacy
Elliott Wolin, Justin White, James V. Pottala, Maciek Sasinowski, Tara Dall, Thomas D. Dayspring, Joseph P. McConnell, Daniel M. Hoefner, Stephen A. Varvel, Dawn L. Thiselton, G. Russell Warnick, William S. Harris
JOURNAL OF CLINICAL LIPIDOLOGY
(2015)
Article
Pharmacology & Pharmacy
Stephen A. Varvel, Thomas D. Dayspring, Yvette Edmonds, Dawn L. Thiselton, Leila Ghaedi, Szilard Voros, Joseph P. McConnell, Maciek Sasinowski, Tara Dall, G. Russell Warnick
JOURNAL OF CLINICAL LIPIDOLOGY
(2015)
Article
Hematology
Steve Varvel, Joseph P. McConnell, Sotirios Tsimikas
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Article
Computer Science, Interdisciplinary Applications
Steven Thompson, Stephen Varvel, Maciek Sasinowski, James P. Burke
Article
Endocrinology & Metabolism
Diana L. Cousminer, Emma Ahlqvist, Rajashree Mishra, Mette K. Andersen, Alessandra Chesi, Mohammad I. Hawa, Asa Davis, Kenyaita M. Hodge, Jonathan P. Bradfield, Kaixin Zhou, Vanessa C. Guy, Mikael Akerlund, Mette Wod, Lars G. Fritsche, Henrik Vestergaard, James Snyder, Kurt Hojlund, Allan Linneberg, Annemari Karajamaki, Ivan Brandslund, Cecilia E. Kim, Daniel Witte, Elin Pettersen Sorgjerd, David J. Brillon, Oluf Pedersen, Henning Beck-Nielsen, Niels Grarup, Richard E. Pratley, Michael R. Rickels, Adrian Vella, Fernando Ovalle, Olle Melander, Ronald I. Harris, Stephen Varvel, Valdemar E. R. Grill, Hakon Hakonarson, Philippe Froguel, John T. Lonsdale, Didac Mauricio, Nanette C. Schloot, Kamlesh Khunti, Carla J. Greenbaum, Bjorn Olav Asvold, Knud B. Yderstraede, Ewan R. Pearson, Stanley Schwartz, Benjamin F. Voight, Torben Hansen, Tiinamaija Tuomi, Bernhard O. Boehm, Leif Groop, R. David Leslie, Struan F. A. Grant
Article
Pharmacology & Pharmacy
William S. Harris, Stephen A. Varvel, James V. Pottala, G. Russell Warnick, Joseph P. McConnell
JOURNAL OF CLINICAL LIPIDOLOGY
(2013)
Article
Health Care Sciences & Services
Steven Thompson, Stephen Varvel, Szilard Voros, Dawn Thiselton, Shahrzad Grami, Ralph M. Turner, John Barron
POPULATION HEALTH MANAGEMENT
(2014)
Article
Cardiac & Cardiovascular Systems
William S. Harris, James V. Pottala, Dawn L. Thiselton, Stephen A. Varvel, Alison M. Baedke, Thomas D. Dayspring, G. Russell Warnick, Joseph P. McConnell
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2014)
Article
Endocrinology & Metabolism
Rajashree Mishra, Mikael Akerlund, Diana L. Cousminer, Emma Ahlqvist, Jonathan P. Bradfield, Alessandra Chesi, Kenyaita M. Hodge, Vanessa C. Guy, David J. Brillon, Richard E. Pratley, Michael R. Rickels, Adrian Vella, Fernando Ovalle, Ronald I. Harris, Olle Melander, Stephen Varvel, Hakon Hakonarson, Phillippe Froguel, John T. Lonsdale, Didac Mauricio, Nanette C. Schloot, Kamlesh Khunti, Carla J. Greenbaum, Knud B. Yderstraede, Tiinamaija Tuomi, Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Leif Groop, Richard David Leslie, Struan F. A. Grant
Article
Cardiac & Cardiovascular Systems
Peter Willeit, Calvin Yeang, Patrick M. Moriarty, Lena Tschiderer, Stephen A. Varvel, Joseph P. McConnell, Sotirios Tsimikas
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biology
Lisette dePillis, Rebecca Caffrey, Ge Chen, Mark D. Dela, Leif Eldevik, Joseph McConnell, Shahrokh Shabahang, Stephen A. Varvel
Summary: This study presents a mathematical model that predicts antibody levels over time after vaccination, providing insights into the connections between antibody levels, protective immunity, and breakthrough infections, and potentially guiding decisions about booster vaccinations.
JOURNAL OF THEORETICAL BIOLOGY
(2023)
Article
Immunology
Hong Liu, Stephen Varvel, Ge Chen, Joseph McConnell, Rebecca Caffrey, Marzena Galdzicka, Shahrokh Shabahang
Summary: By developing a novel multiplex test system, both neutralizing antibodies (NAbs) and antibodies against multiple SARS-CoV-2 variants/subvariants can be reliably detected. Distinguishing NAbs to the appropriate antigenic target offers the best correlate of protection, aiding individual decisions about the appropriateness and cadence of vaccine boosters and other exposure mitigation strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
P. Willeit, C. Yeang, P. M. Moriarty, L. Tschiderer, S. A. Varvel, J. P. Mcconnell, S. Tsimikas
Article
Hematology
Patrick M. Moriarty, Stephen A. Varvel, Philip L. S. M. Gordts, Joseph P. McConnell, Sotirios Tsimikas
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)