Antiplatelet Therapy: Targeting the TxA2 Pathway

Aspirin for the Prevention of Cardiovascular Disease: U.S. Preventive Services Task Force Recommendation Statement

(2013)   ANNALS OF INTERNAL MEDICINE

Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study

(2013) Gregg W Stone et al.   LANCET

Mass Spectrometry–Based Proteomics and Network Biology

(2012) Ariel Bensimon et al.   Annual Review of Biochemistry

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target

(2012) S. Pascale et al.   BLOOD

Antiplatelet Drug Response Status Does Not Predict Recurrent Ischemic Events in Stable Cardiovascular Patients

(2012) Jean-Luc Reny et al.   CIRCULATION

Genetic variants that affect platelet function

(2012) Thomas J. Kunicki et al.   CURRENT OPINION IN HEMATOLOGY

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

(2012) et al.   EUROPEAN HEART JOURNAL

ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

(2012) et al.   EUROPEAN HEART JOURNAL

Single ascending oral dose pharmacokinetics and pharmacodynamics study of EV-077: the specific inhibitor of prostanoid- and isoprostane-induced cellular activation

(2012) A. Richardson et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes

(2012) B. ROCCA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pharmacodynamic effects of EV-077: results of an in vitro pilot investigation in healthy volunteers

(2012) Antonio Tello-Montoliu et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Eicosanoids and Their Drugs in Cardiovascular Diseases: Focus on Atherosclerosis and Stroke

(2012) Valérie Capra et al.   MEDICINAL RESEARCH REVIEWS

Ozagrel for acute ischemic stroke: a meta-analysis of data from randomized controlled trials

(2012) Jing Zhang et al.   NEUROLOGICAL RESEARCH

Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism

(2012) Timothy A. Brighton et al.   NEW ENGLAND JOURNAL OF MEDICINE

EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin

(2012) Kjell S. Sakariassen et al.   THROMBOSIS RESEARCH

High On‐Aspirin Platelet Reactivity and Clinical Outcome in Patients With Stable Coronary Artery Disease: Results From ASCET (Aspirin Nonresponsiveness and Clopidogrel Endpoint Trial)

(2012) Alf‐Åge R. Pettersen et al.   Journal of the American Heart Association

MicroRNAs in platelet production and activation

(2011) L. C. Edelstein et al.   BLOOD

Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity

(2011) S. Nagalla et al.   BLOOD

The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis

(2011) Prasanna Ekambaram et al.   CANCER AND METASTASIS REVIEWS

Pharmacodynamic Effects of Different Aspirin Dosing Regimens in Type 2 Diabetes Mellitus Patients With Coronary Artery Disease

(2011) Davide Capodanno et al.   Circulation-Cardiovascular Interventions

Antiplatelet effects of aspirin vary with level of P2Y12 receptor blockade supplied by either ticagrelor or prasugrel

(2011) N. S. KIRKBY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial

(2011) Marie-Germaine Bousser et al.   LANCET

Thromboxane and the thromboxane receptor in cardiovascular disease

(2010) Emer M Smyth   Clinical Lipidology

Aspirin for Prevention of Cardiovascular Events in a General Population Screened for a Low Ankle Brachial IndexA Randomized Controlled Trial

(2010) F. Gerald R. Fowkes   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Thromboxane Antagonism with terutroban in Peripheral Arterial Disease: the TAIPAD study

(2010) J. N. FIESSINGER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation

(2010) P. C. J. ARMSTRONG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

(2010) Peter M Rothwell et al.   LANCET

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists

(2010) Andrew D Johnson et al.   NATURE GENETICS

Effect of the Thromboxane Prostaglandin Receptor Antagonist Terutroban on Arterial Thrombogenesis after Repeated Administration in Patients Treated for the Prevention of Ischemic Stroke

(2009) C. Bal dit Sollier et al.   CEREBROVASCULAR DISEASES

VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA

(2009) A. A. KONDKAR et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials

(2009)   LANCET

Different expression of proteins in platelets from aspirin-resistant and aspirin-sensitive patients

(2009) P. J. Mateos-Cáceres et al.   THROMBOSIS AND HAEMOSTASIS

Signal-Dependent Protein Synthesis by Activated Platelets

(2008) Guy A. Zimmerman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Use of the PFA-100™ closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: a systematic review and meta-analysis

(2008) J.-L. RENY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thromboxane A2: Physiology/pathophysiology, cellular signal transduction and pharmacology

(2008) Norimichi Nakahata   PHARMACOLOGY & THERAPEUTICS