Meet Me Halfway: When Genomics Meets Structural Bioinformatics

Mouse Models of Cancer

(2011) Dong-Joo Cheon et al.   Annual Review of Pathology-Mechanisms of Disease

Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences

(2010) Rita Gemayel et al.   Annual Review of Genetics

Structural Variation in the Human Genome and its Role in Disease

(2010) Paweł Stankiewicz et al.   Annual Review of Medicine

Easy retrieval of single amino-acid polymorphisms and phenotype information using SwissVar

(2010) Anaïs Mottaz et al.   BIOINFORMATICS

DMDM: domain mapping of disease mutations

(2010) T. A. Peterson et al.   BIOINFORMATICS

Transgenic mouse models of multiple sclerosis

(2010) Tanja Scheikl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel TSHR mutations in consanguineous families with congenital nongoitrous hypothyroidism

(2010) Hakan Cangul et al.   CLINICAL ENDOCRINOLOGY

Small insertions and deletions (INDELs) in human genomes

(2010) J. M. Mullaney et al.   HUMAN MOLECULAR GENETICS

Toward Classification of BRCA1 Missense Variants Using a Biophysical Approach

(2010) Pamela J. E. Rowling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Copy number variation and human genome maps

(2010) Steven A McCarroll   NATURE GENETICS

Public data archives for genomic structural variation

(2010) Deanna M Church et al.   NATURE GENETICS

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

AUTO-MUTE: web-based tools for predicting stability changes in proteins due to single amino acid replacements

(2010) M. Masso et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Diversity of Human Copy Number Variation and Multicopy Genes

(2010) Peter H. Sudmant et al.   SCIENCE

Applications of New Sequencing Technologies for Transcriptome Analysis

(2009) Olena Morozova et al.   Annual Review of Genomics and Human Genetics

Structural and functional restraints in the evolution of protein families and superfamilies

(2009) Sungsam Gong et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

BIPA: a database for protein–nucleic acid interaction in 3D structures

(2009) Semin Lee et al.   BIOINFORMATICS

Fast and accurate predictions of protein stability changes upon mutations using statistical potentials and neural networks: PoPMuSiC-2.0

(2009) Yves Dehouck et al.   BIOINFORMATICS

CREDO: A Protein-Ligand Interaction Database for Drug Discovery

(2009) Adrian Schreyer et al.   Chemical Biology & Drug Design

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

(2009) Sérgia Velho et al.   HUMAN MOLECULAR GENETICS

The SAAPdb web resource: A large-scale structural analysis of mutant proteins

(2009) Jacob M. Hurst et al.   HUMAN MUTATION

Tumor risks and genotype–phenotype–proteotype analysis in 358 patients with germline mutations inSDHBandSDHD

(2009) Christopher J. Ricketts et al.   HUMAN MUTATION

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

(2009) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Genomic copy number variation, human health, and disease

(2009) Louise V Wain et al.   LANCET

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

(2009) Semin Lee et al.   Molecular BioSystems

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Human genetic variation and its contribution to complex traits

(2009) Kelly A. Frazer et al.   NATURE REVIEWS GENETICS

WormBase: a comprehensive resource for nematode research

(2009) Todd W. Harris et al.   NUCLEIC ACIDS RESEARCH

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis

(2009) Julia R. Forman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Linkage Disequilibrium and Association Mapping

(2008) B.S. Weir   Annual Review of Genomics and Human Genetics

Next-Generation DNA Sequencing Methods

(2008) Elaine R. Mardis   Annual Review of Genomics and Human Genetics

Next-generation sequencing: applications beyond genomes

(2008) Samuel Marguerat et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Annotating single amino acid polymorphisms in the UniProt/Swiss-Prot knowledgebase

(2008) Yum L. Yip et al.   HUMAN MUTATION

The complete genome of an individual by massively parallel DNA sequencing

(2008) David A. Wheeler et al.   NATURE

Ion mobility–mass spectrometry analysis of large protein complexes

(2008) Brandon T Ruotolo et al.   Nature Protocols

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

The road to genome-wide association studies

(2008) Leonid Kruglyak   NATURE REVIEWS GENETICS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Ensembl 2009

(2008) T. J. P. Hubbard et al.   NUCLEIC ACIDS RESEARCH

Comparative modelling by restraint-based conformational sampling

(2008) Nicholas Furnham et al.   BMC STRUCTURAL BIOLOGY

Prediction by Graph Theoretic Measures of Structural Effects in Proteins Arising from Non-Synonymous Single Nucleotide Polymorphisms

(2008) Tammy M. K. Cheng et al.   PLoS Computational Biology

Discarding Functional Residues from the Substitution Table Improves Predictions of Active Sites within Three-Dimensional Structures

(2008) Sungsam Gong et al.   PLoS Computational Biology

Understanding the molecular machinery of genetics through 3D structures

(2007) Roman A. Laskowski et al.   NATURE REVIEWS GENETICS

Distance-scaled, finite ideal-gas reference state improves structure-derived potentials of mean force for structure selection and stability prediction

(2002) Hongyi Zhou et al.   PROTEIN SCIENCE