Article
Oncology
Zuzana Pokorna, Vaclav Hrabal, Vlastimil Tichy, Borivoj Vojtesek, Philip J. Coates
Summary: The TP63 gene encodes two major protein variants that have distinct expression patterns and activities in normal tissues and tumors. DNA methylation plays a role in regulating the expression of these variants, and targeting DNA methylation may have therapeutic potential in cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Nan Wang, Xuanyu Huang, Jinsheng Cheng
Summary: The study found that BIRC5 was strongly correlated with higher tumor grade and differentiation in Laryngeal squamous cell carcinoma (LSCC), and increased expression of BIRC5 was associated with overall survival in LSCC patients. Suppression of BIRC5 induced cell apoptosis and cell cycle arrest, inhibiting proliferation of LSCC cells. Higher level of BIRC5 expression predicted poor prognosis of LSCC patients, suggesting BIRC5 as a promising prognostic biomarker for LSCC.
Review
Immunology
Vahide Saeidi, Nicole Doudican, John A. Carucci
Summary: Primary cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with a rising incidence of about 1.8 million in the United States annually. Surgery is usually curative, but in some cases, cSCC can metastasize and result in death. The introduction of checkpoint inhibitor immunotherapy has significantly improved treatment outcomes for advanced or metastatic cSCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Zhenning Li, Lixia Zhang, Fa-yu Liu, Peng Li, Jing He, Cameron L. Kirkwood, Jiho Sohn, Jon M. Chan, William J. Magner, Keith L. Kirkwood
Summary: The study showed that the expression of MKP-1 in oral squamous cell carcinoma is inversely related to oral cancer burden and nodal involvement, and the role of MKP-1 signaling in tumor associated macrophages (TAMs) was assessed in murine models of OSCC. The results indicated that myeloid-based Dusp1 deficiency increases OSCC burden and metastasis through alteration in TAM recruitment, gene profile, and polarity.
Article
Biochemistry & Molecular Biology
Sarah Adriana Scuderi, Giovanna Casili, Rossella Basilotta, Marika Lanza, Alessia Filippone, Gabriele Raciti, Ivana Puliafito, Lorenzo Colarossi, Emanuela Esposito, Irene Paterniti
Summary: Oral cancer, characterized by high invasiveness and low survival rate, requires new treatments. Research shows that the NLRP3 inflammasome inhibitor BAY-117082 can effectively inhibit oral cancer cell viability and modulate key signaling pathways, offering a promising strategy to counteract oral cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ramona Erber, Steffen Spoerl, Andreas Mamilos, Rosemarie Krupar, Arndt Hartmann, Matthias Ruebner, Juergen Taxis, Mareike Wittenberg, Torsten E. Reichert, Gerrit Spanier, Silvia Spoerl
Summary: The study found that in patients with oral squamous cell carcinoma (OSCC), a combined high central and low peripheral Trop-2 expression was associated with lower survival rates, while patients with lower central and/or higher peripheral Trop-2 expression had higher survival rates after five years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chunguang Zhao, Zhiyun Liu
Summary: It has been discovered that SERPINE1 is highly expressed in oral squamous cell carcinoma (OSCC) and exerts oncogenic effects through a mechanism mediated by miR-617. The miR-617/SERPINE1 axis may serve as a potential therapeutic target for OSCC.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Chemistry, Medicinal
Guya Diletta Marconi, Ylenia Della Rocca, Luigia Fonticoli, Francesco Melfi, Thangavelu Soundara Rajan, Simone Carradori, Jacopo Pizzicannella, Oriana Trubiani, Francesca Diomede
Summary: The study aims to evaluate the role of c-Myc in the pathogenesis of oral squamous cell carcinoma (OSCC). The results show the vital role of c-Myc in tumor growth and cell survival/proliferation, along with the inhibitory effect of Doxorubicin (Doxo) on c-Myc signaling pathway.
Article
Pathology
Yanru Yang, Saijie Zuo, Wenqing Li, Man Di, Jin Liu, Jia Chai, Jingjing Wang, Yuan Yuan, Mingyang Li, Qingge Jia
Summary: TRIM21 is highly expressed in cervical squamous cell carcinoma (CESC) tissues compared with paracancerous tissues. The overexpression of TRIM21 promotes cell proliferation, migration, invasion, and stemness, while knockdown of TRIM21 inhibits tumor cell activities in CESC. Furthermore, TRIM21 expression levels are associated with individual prognostic factors and may serve as a poor predictor of prognosis for CESC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Wei Chen, Xijuan Chen, Lixuan Wang, Rongchun Yang, Weilin Zhang, Siyuan Zhang, Juan Xia, Bin Cheng, Tong Wu, Xianyue Ren
Summary: Mitochondria are key in maintaining oxidative balance and cell death regulation during cancer cell growth. TIPE3 downregulation through promoter hypermethylation is the main alteration in TIPEs during HNSCC development.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du
Summary: The study reveals that miR-106b-5p enhances proliferation, colony formation, adhesion, migration, and invasion, and induces cell cycle progression, while repressing apoptosis in esophageal squamous cell carcinoma (ESCC) by targeting HPGD. This finding suggests that the miR-106b-5p/HPGD axis may serve as a promising target for the diagnosis and treatment of ESCC.
Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Mari Komatsu, Kengo Saito, Isao Miyamoto, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Atsushi Kasamatsu, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Summary: The expression of GIMAP2 is significantly upregulated in oral squamous cell carcinoma, and it plays an important role in cell growth and apoptosis.
Article
Biotechnology & Applied Microbiology
Yue Xiao, Yanjun Duan, Yongjie Wang, Xiaojia Yin
Summary: The study demonstrated that resveratrol inhibits the growth and promotes apoptosis of CAL-27 oral squamous cell carcinoma cells by regulating the ZNF750/RAC1 signaling pathway. Resveratrol also suppresses malignant progression by modulating the expression of angiogenin, cell adhesion molecules, and vascular markers.
Article
Oncology
Chengzhi Xu, Yunbin Zhang, Yupeng Shen, Yong Shi, Ming Zhang, Liang Zhou
Summary: This study identified ENDOU as a biomarker with prognostic significance in HNSCC progression. Overexpression of ENDOU inhibited proliferation and migration of FaDu and Cal-27 cells, indicating its tumor-suppressing role in HNSCC progression. GSEA analysis revealed ENDOU downstream pathways such as DNA replication, mismatch repair, cell cycle, and IL-17 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)