Article
Plant Sciences
Ashraf M. Omar, Sijia Sun, Min Jo Kim, Nguyen Duy Phan, Ahmed M. Tawila, Suresh Awale
Summary: The antiausterity strategy shows promise in discovering lead compounds with unprecedented anticancer activities by targeting cancer cells' tolerance to nutrition starvation. The study isolated multiple compounds, including six new benzophenones, from an ethanol extract of Betula alnoides, which displayed antiausterity activity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions. These new compounds showed potential anticancer effects and induced alterations in cancer cell morphology under nutrient-deprived conditions.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Juthamart Maneenet, Ahmed M. Tawila, Ashraf M. Omar, Nguyen Duy Phan, Chiharu Ojima, Masahiro Kuroda, Mao Sato, Mio Mizoguchi, Ikue Takahashi, Suresh Awale
Summary: An n-hexane extract from Callistemon subulatus exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cells, particularly under nutrition starvation conditions. Among the isolated compounds, myrtucommulone A (2) demonstrated highly preferential cytotoxicity against the cancer cells and induced cell death through inhibition of cell migration and downregulation of signaling pathways.
Article
Biochemistry & Molecular Biology
Yuki Fujihashi, Min Jo Kim, Juthamart Maneenet, Suresh Awale
Summary: This study explores the potential of Piper longum constituents as anti-austerity agents for pancreatic cancer. The ethanolic extract of Piper longum was found to selectively inhibit the survival of PANC-1 human pancreatic cancer cells under nutrient deprivation. Pipernonaline (3) was identified as the lead compound with the strongest anti-austerity activity, inducing cell death, inhibiting migration, and suppressing the Akt/mTOR/autophagy pathway. Pipernonaline (3) shows promise as a novel anti-austerity agent for the treatment of pancreatic cancer.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Environmental Sciences
Mahdieh Farhoudi Sefidan Jadid, Behrouz Shademan, Reza Chavoshi, Nasrin Seyyedsani, Elnaz Aghaei, Elham Taheri, Pouya Goleij, Saba Hajazimian, Vahidreza Karamad, Javad Behroozi, Mehrdad Nasrollahzadeh Sabet, Alireza Isazadeh, Behzad Baradaran
Summary: The combination of Hyd and Cur, as well as nano-encapsulation therapy, showed more profound apoptotic and anti-proliferative effects on PANC-1 cells compared to free Hyd or Hyd monotherapy.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Prasad Narayanan, Reyhaneh Farghadani, Shaik Nyamathulla, Jayakumar Rajarajeswaran, R. Thirugnanasampandan, Gunasekaran Bhuwaneswari
Summary: Thymoquinone, plumbagin and juglone have promising anticancer effects on human pancreatic cancer cells, inhibiting cell growth and inducing apoptosis through increased reactive oxygen species (ROS) levels. In addition, they also inhibit cell migration and reduce the expression of matrix metalloproteinase-9 (MMP-9).
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anpeng Li, Xiang Li, Jihua Zou, Xiaobin Zhuo, Shuai Chen, Xiaoyun Chai, Conghao Gai, Weiheng Xu, Qingjie Zhao, Yan Zou
Summary: A series of hydrocarbon-stapled peptides were designed and synthesized to mimic the alpha-helix of SOS1 as pan-Ras inhibitors. Among these peptides, SSOSH-5 showed a well-constrained alpha-helical structure and high affinity for H-Ras binding. Structural modeling analysis confirmed the binding similarity of SSOSH-5 to the parent linear peptide. SSOSH-5 effectively inhibited the proliferation of pan-Ras-mutated cancer cells and induced dose-dependent apoptosis by modulating downstream kinase signaling.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Xian Hong, Zhi-Xuan Li, Jie Hou, Hui-Yu Zhang, Chun-Yan Zhang, Jian Zhang, He Sun, Li-Hong Pang, Tao Wang, Zhi-Hui Deng
Summary: The secreted form of AGR2 plays a major role in promoting cell proliferation, migration, and invasion in PANC-1 pancreatic cancer cells. Both secreted and ER-resident forms of AGR2 enhance the survival of PANC-1 cells under challenging conditions. However, EGFR expression and activation do not appear to be involved in AGR2-mediated oncogenic phenotypes in PANC-1 cells.
Article
Chemistry, Medicinal
Sijia Sun, Ashraf M. Omar, Min Jo Kim, Nguyen Duy Phan, Yaowared Chulikhit, Suresh Awale
Summary: The methanolic extract of Thai Piper ribesoides exhibited preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived conditions, with a PC50 value of 24 μg/mL. Six compounds were isolated from the extract, including two new polyoxygenated cyclohexane derivatives. Compounds 1, 3, and 4 showed potent preferential cytotoxic activity against PANC-1 cells, with PC50 values ranging from 5.5-7.2 μM, while ribesoidone A (1) also inhibited colony formation of PANC-1 under normal nutrient-rich conditions.
Article
Biochemistry & Molecular Biology
Lingchen Tao, Xi Chen, Yufei Zheng, Yuqi Wu, Xiasen Jiang, Mengmeng You, Shanshan Li, Fuliang Hu
Summary: The study demonstrated that Chinese propolis has a significant anticancer effect on pancreatic cancer cells Panc-1 by inducing apoptosis, inhibiting cell migration, and activating the Hippo pathway to suppress tumor growth.
Article
Chemistry, Medicinal
Silong Zhang, Yu Zhang, Xin Chen, Juan Xu, Huaxiang Fang, Yuanyuan Li, Yi Liu, Huan He
Summary: KRAS mutations play a crucial role in the development and progression of cancer, and SOS1 is a key regulator of KRAS activity. In this study, a new tetra-cyclic quinazoline derivative (Compound 37) was identified as an inhibitor of the SOS1-KRAS interaction, with improved pharmacokinetic properties and significant anti-tumor effects in experimental models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Hao Jin, Minsoo Koh, Hyesol Lim, Hae-Young Yong, Eun-Sook Kim, Sun Young Kim, Kyoungmee Kim, Joohee Jung, Won-Ji Ryu, Kang-Yell Choi, Aree Moon
Summary: Ras mutations are common in human cancer. Flot-1 interacts with H-Ras/K-Ras and may serve as a potential therapeutic target for Ras-driven cancers.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
John M. M. Baust, Kimberly L. Santucci, Robert G. Van Buskirk, Isaac Raijman, William E. Fisher, John G. G. Baust, Kristi K. Snyder
Summary: As the incidence of PDAC continues to grow, new treatment strategies are needed. This study investigated the response of PDAC cells to freezing, chemotherapy, and their combination. The results showed that freezing alone can effectively destroy PDAC cells and combining freezing with chemotherapy further enhances the therapeutic effect.
Article
Chemistry, Applied
Ashraf M. Omar, Dya Fita Dibwe, Ahmed M. Tawila, Sijia Sun, Min Jo Kim, Suresh Awale
Summary: The 70% ethanolic extract of Artemisia vulgaris exhibited preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with the identification of a new compound, (+)-vulgaric acid (1), showing strong cytotoxicity. Apigenin (3) showed the highest cytotoxic activity among the tested compounds.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Takuya Okada, Yuri Chino, Keita Yokoyama, Yuki Fujihashi, Nguyen Duy Phan, Juthamart Maneenet, Lanke Prudhvi, Suresh Awale, Naoki Toyooka
Summary: Pipernonaline, a component of spice pepper, selectively reduces the survival of pancreatic cancer cells under nutrient-deprived conditions. Its derivative compound 9 exhibits the strongest cytotoxicity and inhibits Akt activation and cancer cell migration, making it a promising candidate for new pancreatic cancer agents based on the anti-austerity strategy.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Ahmed M. Tawila, Ashraf M. Omar, Nguyen Duy Phan, Ikue Takahashi, Juthamart Maneenet, Suresh Awale
Summary: Phytochemical investigation of Callistemon citrinus leaves led to the discovery of two new compounds, callistrilone Q(1) and epicallistrilone Q(2), which exhibited unprecedented cytotoxic activities against human pancreatic cancer cells and inhibited cell migration.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Lin Feng, Hai-Bo Li, Hao Gao, Yan Huang, Wen-Xia Zhou, Yang Yu, Xin-Sheng Yao
MAGNETIC RESONANCE IN CHEMISTRY
(2016)
Review
Chemistry, Applied
Xiaorui Zhang, Chunhui Qi, Yan Guo, Wenxia Zhou, Yongxiang Zhang
CARBOHYDRATE POLYMERS
(2016)
Article
Neurosciences
Jianhui Wang, Fuqiang Ye, Xiaorui Cheng, Xiaorui Zhang, Feng Liu, Gang Liu, Ming Ni, Shanyi Qiao, Wenxia Zhou, Yongxiang Zhang
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Neurosciences
Dong Li, Yan Huang, Bin Cheng, Jie Su, Wen-Xia Zhou, Yong-Xiang Zhang
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Environmental Sciences
Xiaorui Zhang, Yizhou Mei, Tongxing Wang, Feng Liu, Ning Jiang, Wenxia Zhou, Yongxiang Zhang
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Shufang Feng, Tianyao Shi, Jiangxia Qiu, Haihong Yang, Yan Wu, Wenxia Zhou, Wei Wang, Haitao Wu
Article
Neurosciences
Jianhui Wang, Yang Liu, Xiaorui Cheng, Xiaorui Zhang, Feng Liu, Gang Liu, Shanyi Qiao, Ming Ni, Wenxia Zhou, Yongxiang Zhang, Fei Li
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Geriatrics & Gerontology
Jianhui Wang, Xiaorui Cheng, Ju Zeng, Jiangbei Yuan, Zhongfu Wang, Wenxia Zhou, Yongxiang Zhang
Article
Biochemistry & Molecular Biology
Tongxing Wang, Lu Han, Xiaorui Zhang, Rongrong Wu, Xiaorui Cheng, Wenxia Zhou, Yongxiang Zhang
Article
Neurosciences
Tian-Yao Shi, Shu-Fang Feng, Ming-Xiao Wei, Yan Huang, Gang Liu, Hai Tao Wu, Yong-Xiang Zhang, Wen-Xia Zhou
Article
Pharmacology & Pharmacy
Rongrong Wu, Zhiyong Xiao, Xiaorui Zhang, Feng Liu, Wenxia Zhou, Yongxiang Zhang
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Neurosciences
Mei Xu, Lin Zhang, Gang Liu, Ning Jiang, Wenxia Zhou, Yongxiang Zhang
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Plant Sciences
Yan Huang, Dong Li, Bin Cheng, Gang Liu, Yong-Xiang Zhang, Wen-Xia Zhou
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Integrative & Complementary Medicine
Cheng Xiao-Rui, Qi Chun-Hui, Wang Tong-Xing, Zhou Wen-Xia, Zhang Yong-Xiang
CHINESE JOURNAL OF NATURAL MEDICINES
(2019)
Article
Clinical Neurology
Jianhui Wang, Xiaorui Zhang, Xiaorui Cheng, Junping Cheng, Feng Liu, Yiran Xu, Ju Zeng, Shanyi Qiao, Wenxia Zhou, Yongxiang Zhang
CURRENT ALZHEIMER RESEARCH
(2017)