Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants

Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage

(2012) Haseeb Zubair et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Oral administration of copper to rats leads to increased lymphocyte cellular DNA degradation by dietary polyphenols: implications for a cancer preventive mechanism

(2011) Husain Y. Khan et al.   BIOMETALS

The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer

(2010) M. F. Ullah et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species

(2010) Padma Sandeep Koka et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

(2009) Nahed El-Najjar et al.   APOPTOSIS

Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A

(2009) Mohd Fahad Ullah et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells

(2009) S. Nazeem et al.   MUTAGENESIS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: Implications for an anticancer mechanism

(2008) Uzma Shamim et al.   FREE RADICAL RESEARCH

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

(2008) T. Yi et al.   MOLECULAR CANCER THERAPEUTICS