Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent ‘type I’ mode

Disruption of the VDAC2–Bak interaction by Bcl-xS mediates efficient induction of apoptosis in melanoma cells

(2012) M Plötz et al.   CELL DEATH AND DIFFERENTIATION

Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma

(2010) Bernhard Gillissen et al.   JOURNAL OF CELL BIOLOGY

Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

(2010) Alan D. Brooks et al.   MOLECULAR CANCER RESEARCH

Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis

(2010) M Hörnle et al.   ONCOGENE

New insights into apoptosis signaling by Apo2L/TRAIL

(2010) F Gonzalvez et al.   ONCOGENE

XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL

(2010) Patrick Hundsdoerfer et al.   PEDIATRIC BLOOD & CANCER

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

(2009) M. Vogler et al.   CANCER RESEARCH

Bortezomib Overcomes Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance in Hepatocellular Carcinoma Cells in Part through the Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway

(2009) Kuen-Feng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

BH3 Mimetic ABT-737 Potentiates TRAIL-Mediated Apoptotic Signaling by Unsequestering Bim and Bak in Human Pancreatic Cancer Cells

(2008) S. Huang et al.   CANCER RESEARCH

Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism

(2008) Gustavo Ortiz-Ferrón et al.   CELL RESEARCH

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE