Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 2, Issue 6, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a000588
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Funding
- Medical Research Council (UK)
- Wellcome Trust
- Fundacao para a Ciencia e a Tecnologia (Portugal)
- Biotechnology and Biological Sciences Research Council [BB/H008098/1] Funding Source: researchfish
- Medical Research Council [MC_U120061476] Funding Source: researchfish
- BBSRC [BB/H008098/1] Funding Source: UKRI
- MRC [MC_U120061476] Funding Source: UKRI
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Eukaryotic gene expression is an intricate multistep process, regulated within the cell nucleus through the activation or repression of RNA synthesis, processing, cytoplasmic export, and translation into protein. The major regulators of gene expression are chromatin remodeling and transcription machineries that are locally recruited to genes. However, enzymatic activities that act on genes are not ubiquitously distributed throughout the nucleoplasm, but limited to specific and spatially defined foci that promote preferred higher-order chromatin arrangements. The positioning of genes within the nuclear landscape relative to specific functional landmarks plays an important role in gene regulation and disease.
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